Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andrew John Potter"'
Autor:
David A. Robinson, Claire L. Nunns, Christopher J. Northfield, Jonathan D. Moore, Christine M. Richardson, Ben Davis, James Brooke Murray, Victoria Oldfield, Pawel Dokurno, Simon F. Scrace, Lisa Baker, Stuart C. Ray, Christophe Fromont, Allan E. Surgenor, Natalia Matossova, Andrew John Potter, Christopher J. Bryant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6483-6488
Pin1 is an emerging oncology target strongly implicated in Ras and ErbB2-mediated tumourigenesis. Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling. Here we
Autor:
Shabana Mirza, Mohammad Afshar, Alastair I.H. Murchie, Jonathan Karn, Andrew John Potter, Fareed Aboul-ela, Terry Mark Swarbrick, Catherine Isel, Philippe Vaglio, Martin J. Drysdale, Ian David Starkey, Catherine Denise Prescott, Ben Davis, Justin Bower
Publikováno v:
Journal of Molecular Biology. 336:625-638
The targeting of RNA for the design of novel anti-viral compounds represents an area of vast potential. We have used NMR and computational methods to model the interaction of a series of synthetic inhibitors of the in vitro RNA binding activities of
Autor:
Jonathan Karn, Gabriele Varani, Terry Mark Swarbrick, Ben Davis, Ian David Starkey, Mohammad Afshar, Andrew John Potter, Alastair I.H. Murchie, Martin J. Drysdale, Justin Bower, Georg Lentzen, Fareed Aboul-ela
Publikováno v:
Journal of molecular biology. 336(2)
The targeting of RNA for the design of novel anti-viral compounds has until now proceeded largely without incorporating direct input from structure-based design methodology, partly because of lack of structural data, and complications arising from su