Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrew John, Harvey"'
Publikováno v:
Turkish Journal of Botany. 46:92-108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d103b220d95be4fdf5b317a1feb5677b
https://doi.org/10.55730/1300-008x.2674
https://doi.org/10.55730/1300-008x.2674
Autor:
Joshua D. Vardigan, Anton A. Grishin, Fiona Thomson, Michelle Pearson, Joseph L. Duffy, Corin O. Miller, Jason M. Uslaner, Xiaoping Zhou, Christopher Daley, Andrew John Harvey, Sue O'connor, Lee Warren, Ian M. Bell, Carolyn J. Coles, Michelle Belden, Henry S. Lange, Xiaohai Wang, Vanita Gakhar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:311-324
Treatments for cognitive deficits associated with central nervous system (CNS) disorders such as Alzheimer disease and schizophrenia remain significant unmet medical needs that incur substantial pressure on the health care system. The α7 nicotinic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c3e2e8af05e10d005297f7acb0e5f63
https://doi.org/10.1124/jpet.119.263483
https://doi.org/10.1124/jpet.119.263483
Publikováno v:
Progress in molecular biology and translational science. 181
The CRISPR/Cas9 is a RNA-guided nuclease complex that can be specifically programmed to target a user-specified DNA sequence. It has been a powerful and effective tool of genome editing. However, off-target activity of the Cas9 nuclease limits its po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c65c482ce2e9378a61f0d5df6f9d5b89
https://pubmed.ncbi.nlm.nih.gov/34127203
https://pubmed.ncbi.nlm.nih.gov/34127203
Autor:
B. Huyard, Anton A. Grishin, Thomas Avery, Andrew John Harvey, Carolyn J. Coles, Christophe Morice, Belinda C Huff, Stéphanie Wagner, Rajinder Singh, Christophe Joseph, Bruno Giethlen, Sue O'connor, Etienne Poiraud, Emile Andriambeloson, Peter Kolesik, Dharam Paul, Laurent Schaeffer
Publikováno v:
ACS Med Chem Lett
[Image: see text] Positive allosteric modulators (PAMs) of α7 nAChRs can have different properties with respect to their effects on channel kinetics. Type I PAMs amplify peak channel response to acetylcholine but do not appear to influence channel d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f238f2d802fa12ba98ac28ab01884c
https://pubmed.ncbi.nlm.nih.gov/31097995
https://pubmed.ncbi.nlm.nih.gov/31097995
Autor:
Thao T. Olson, David E. Hibbs, John Tsanaktsidis, Teresa Xie, Andrew John Harvey, Michael Kassiou, Sue O'connor, Carolyn J. Coles, Corinne Beinat, Yingxian Xiao, Tristan A. Reekie
Publikováno v:
European Journal of Medicinal Chemistry. 84:200-205
Several lines of experimental evidence support the involvement of the α7 nAChR in schizophrenia and Alzheimer's disease. Modulators of the α7 nAChR have been extensively reviewed for the treatment of the cognitive deficits associated with these pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55126f9872d376d418e5aa0efca76eb
https://doi.org/10.1016/j.ejmech.2014.07.029
https://doi.org/10.1016/j.ejmech.2014.07.029
Autor:
Dharam Paul, Robert W. Gable, Jonathan B. Baell, Julia Cianci, Jorgen Alvar Mould, Andrew John Harvey, Bernard L. Flynn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2055-2061
Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab13faabf3e92d6105916af3c666366
https://doi.org/10.1016/j.bmcl.2008.01.099
https://doi.org/10.1016/j.bmcl.2008.01.099
Publikováno v:
Journal of Medicinal Chemistry. 49:1433-1441
The voltage-gated potassium channel Kv1.3 constitutes an attractive target for the selective suppression of effector memory T cells in autoimmune diseases. We have previously reported the natural product khellinone, 1a, as a versatile lead molecule a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558cdcefbe68e159d9ff2e0b9694a6e9
https://doi.org/10.1021/jm050839v
https://doi.org/10.1021/jm050839v
Autor:
Robert W. Gable, Nathan Toovey, Jonathan B. Baell, Tanja Herzog, Andrew John Harvey, Wolfram Hänsel, Heike Wulff
Publikováno v:
Journal of Medicinal Chemistry. 47:2326-2336
The voltage-gated potassium channel Kv1.3 constitutes a promising new target for the treatment of T-cell-mediated autoimmune diseases such as multiple sclerosis. In this study, we report the discovery of two new classes of Kv1.3 blockers based on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fe427bac663682e7b71c989d8f46cb
https://doi.org/10.1021/jm030523s
https://doi.org/10.1021/jm030523s
Publikováno v:
Journal of Computer-Aided Molecular Design. 16:245-262
ShK toxin is a structurally defined, 35-residue polypeptide which blocks the voltage-gated Kv1.3 potassium channel in T-lymphocytes and has been identified as a possible immunosuppressant. Our interest lies in the rational design and synthesis of typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938a9cbace039add0b78499f627d35df
https://doi.org/10.1023/a:1020214720560
https://doi.org/10.1023/a:1020214720560
Autor:
Thao T. Olson, Teresa Xie, John Tsanaktsidis, Carolyn J. Coles, Michael Kassiou, James O'Brien-Brown, Samuel D. Banister, Peter Kolesik, Anton A. Grishin, Andrew John Harvey, Sue O'connor, Tristan A. Reekie, Yingxian Xiao, Corinne Beinat
Publikováno v:
European journal of medicinal chemistry. 95
Alpha7 nicotinic acetylcholine receptors (nAChRs) have implications in the regulation of cognitive processes such as memory and attention and have been identified as a promising therapeutic target for the treatment of the cognitive deficits associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9491234be25d5ebe6a8d1101f3847b2d
https://pubmed.ncbi.nlm.nih.gov/25827398
https://pubmed.ncbi.nlm.nih.gov/25827398