Výsledky vyhledávání - "Andrew Jay Brazier"

Akademický článek

Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum-Infected Erythrocytes to Endothelial Cells

Autor: Marion Avril, Maria Bernabeu, Maxwell Benjamin, Andrew Jay Brazier, Joseph D. Smith

Publikováno v: mBio, Vol 7, Iss 4 (2016)

ABSTRACT Intercellular adhesion molecule 1 (ICAM-1) and the endothelial protein C receptor (EPCR) are candidate receptors for the deadly complication cerebral malaria. However, it remains unclear if Plasmodium falciparum parasites with dual binding s

Externí odkaz: https://doaj.org/article/680f8fcb41bb44bf9f54ad50503af282

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Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein

Autor: Marie K. Mankowski, N. Miranda Nebane, Andrew Jay Brazier, Sara J. Buhrlage, Vikas Misra, Dana Gabuzda, Erez Pery, Roger G. Ptak, Lynn Rasmussen, Kottampatty S. Rajendran, Ann M. Sheehy, E. Lucile White

Publikováno v: Journal of Biological Chemistry. 290:10504-10517

APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA and by deamination-independent mechanisms. HIV-1 Vif binds to A3G, resulting in its degradation via the 26 S proteasome. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db3565ad06467fd86deade1aa0992fb
https://doi.org/10.1074/jbc.m114.626903

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Regulation of APOBEC3 Proteins by a Novel YXXL Motif in Human Immunodeficiency Virus Type 1 Vif and Simian Immunodeficiency Virus SIVagm Vif

Autor: Kottampatty S. Rajendran, Dana Gabuzda, Erez Pery, Andrew Jay Brazier

Publikováno v: Journal of Virology. 83:2374-2381

The APOBEC3 cytidine deaminases are potent antiviral factors that restrict the replication of human immunodeficiency virus type 1 (HIV-1). In HIV-1-infected CD4 + T cells, the viral accessory protein Vif binds to APOBEC3G (A3G), APOBEC3F (A3F), and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4adaab5cb5fd0621e96f6ed53e4b8ff
https://doi.org/10.1128/jvi.01898-08

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Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 Vif and inhibitors of Vif-APOBEC3G binding

Autor: Chengsheng Zhang, Dana Gabuzda, Andrew Jay Brazier, Andrew Mehle, Heather Wilson, Mark McPike, Erez Pery

Publikováno v: Journal of virology. 81(23)

The APOBEC3 cytidine deaminases are potent antiviral factors that restrict replication of human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif binds APOBEC3G and APOBEC3F and targets these proteins for ubiquitination by forming an E3 ubiquitin liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355c86fa16c6a862d85d660ba0848370
https://pubmed.ncbi.nlm.nih.gov/17898068

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