Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Andrew J.H. Smith"'
Autor:
Yu Wang, Michael H. Tatham, Wolfgang Schmidt-Heck, Carolyn Swann, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Tilo Kunath, Timothy R. Rudd, Andrew J.H. Smith, Jan G. Hengstler, Patricio Godoy, Ronald T. Hay, David C. Hay
Publikováno v:
iScience, Vol 16, Iss , Pp 206-217 (2019)
Summary: During mammalian development, liver differentiation is driven by signals that converge on multiple transcription factor networks. The hepatocyte nuclear factor signaling network is known to be essential for hepatocyte specification and maint
Externí odkaz:
https://doaj.org/article/4a91a3c282f3471bad0373765ad436f8
Autor:
Owen R. Davies, Chia-Yi Lin, Aliaksandra Radzisheuskaya, Xinzhi Zhou, Jessica Taube, Guillaume Blin, Anna Waterhouse, Andrew J.H. Smith, Sally Lowell
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 472-484 (2013)
The events that prime pluripotent cells for differentiation are not well understood. Inhibitor of DNA binding/differentiation (Id) proteins, which are inhibitors of basic helix-loop-helix (bHLH) transcription factor activity, contribute to pluripoten
Externí odkaz:
https://doaj.org/article/97cbf2c3a810446b9f806e783c39da4a
Autor:
Jacqueline A. Sharpe, D.M. Jeziorska, B. Christoffer Lagerholm, Doug Higgs, Andrew J.H. Smith, Veronica J. Buckle, Jill M. Brown, Jacqueline A. Sloane-Stanley, Edward Tunnacliffe, Helena Ayyub, Christian Babbs
Determining the mechanisms by which genes are switched on and off during development and differentiation is a key aim of current biomedical research. Gene transcription has been widely observed to occur in a discontinuous fashion, with short bursts o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e4db11b1abd57f4db562bf24fd3a0d
https://doi.org/10.1101/2021.11.26.470114
https://doi.org/10.1101/2021.11.26.470114
Autor:
David C. Hay, Baltasar Lucendo-Villarin, Andrew J.H. Smith, Ronald T. Hay, Jan G. Hengstler, Tilo Kunath, Timothy R. Rudd, Michael H. Tatham, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Patricio Godoy, Yu Wang, Carolyn Swann, Wolfgang Schmidt-Heck
Publikováno v:
iScience, Vol 16, Iss, Pp 206-217 (2019)
iScience
iScience, 16:206-17
Wang, Y, Tatham, M H, Schmidt-Heck, W, Swann, C, Singh Dolt, K, Meseguer Ripolles, J, Lucendo-Villarin, B, Kunath, T, Rudd, T R, Smith, A, Hengstler, J G, Godoy, P & Hay, D C 2019, ' Multiomics analyses of HNF4a protein domain function during human pluripotent stem cell differentiation ', iScience . https://doi.org/10.1016/j.isci.2019.05.028
iScience
iScience, 16:206-17
Wang, Y, Tatham, M H, Schmidt-Heck, W, Swann, C, Singh Dolt, K, Meseguer Ripolles, J, Lucendo-Villarin, B, Kunath, T, Rudd, T R, Smith, A, Hengstler, J G, Godoy, P & Hay, D C 2019, ' Multiomics analyses of HNF4a protein domain function during human pluripotent stem cell differentiation ', iScience . https://doi.org/10.1016/j.isci.2019.05.028
Summary During mammalian development, liver differentiation is driven by signals that converge on multiple transcription factor networks. The hepatocyte nuclear factor signaling network is known to be essential for hepatocyte specification and mainte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d4735d7efb7fedb784d64495dec47c
http://www.sciencedirect.com/science/article/pii/S2589004219301658
http://www.sciencedirect.com/science/article/pii/S2589004219301658
Publikováno v:
Wang, Y, Smith, A & Hay, D 2020, ' Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing ', Journal of Visualized Experiments (JoVE) . https://doi.org/10.3791/61152
Custom designed endonucleases, such as RNA-guided Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9, enable efficient genome editing in mammalian cells. Here we describe detailed procedures to seamlessly genome edit the hepatocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5b5a95c7f6a2511919d864fda7e382
https://doi.org/10.3791/61152-v
https://doi.org/10.3791/61152-v
Autor:
Cristina Tufarelli, Ricarda Gaentzsch, Robert J S Murray, Danuta M. Jeziorska, Jim R. Hughes, Bryony Graham, Marco De Gobbi, Jonathan N. Lund, Andrew J.H. Smith, Helena Ayyub, En Li, Magnus D. Lynch, Taiping Chen, Jelena Telenius, Douglas R. Higgs, David Garrick
Publikováno v:
Jeziorska, D M, Murray, R J S, De Gobbi, M, Gaentzsch, R, Garrick, D, Ayyub, H, Chen, T, Li, E, Telenius, J, Lynch, M, Graham, B, Smith, A J H, Lund, J N, Hughes, J R, Higgs, D R & Tufarelli, C 2017, ' DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease ', Proceedings of the National Academy of Sciences, vol. 114, no. 36, pp. E7526-E7535 . https://doi.org/10.1073/pnas.1703087114
The human genome contains ∼30,000 CpG islands (CGIs). While CGIs associated with promoters nearly always remain unmethylated, many of the ∼9,000 CGIs lying within gene bodies become methylated during development and differentiation. Both promoter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b09643ca63009b33e0f3c4a62192df6
Autor:
Jacqueline A. Sharpe, William G. Wood, Douglas Vernimmen, Ailbhe Jane Brazel, Jacqueline A. Sloane-Stanley, Marco De Gobbi, Andrew J.H. Smith
Publikováno v:
De Gobbi, M, Brazel, A J, Sharpe, J A, Sloane-stanley, J A, Smith, A, Wood, W G & Vernimmen, D 2017, ' Enhancer deletion generates cellular phenotypic diversity due to bimodal gene expression ', Blood Cells, Molecules and Diseases, vol. 64, pp. 10-12 . https://doi.org/10.1016/j.bcmd.2017.02.006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14bb7124969f55a45165eacaf449c8b
https://pubmed.ncbi.nlm.nih.gov/28292728
https://pubmed.ncbi.nlm.nih.gov/28292728
Autor:
Anna Waterhouse, Sally Lowell, Rodrigo Osorno, Ian Chambers, Andrew J.H. Smith, Mattias Malaguti, Xinzhi Zhou, Chia-Yi Lin, Guillaume Blin
Publikováno v:
Stem Cells (Dayton, Ohio)
Robust development of the early embryo may benefit from mechanisms that ensure that not all pluripotent cells differentiate at exactly the same time: such mechanisms would build flexibility into the process of lineage allocation. This idea is support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773c8a9d3d569b3b2dc534068c99e346
https://doi.org/10.1002/stem.1426
https://doi.org/10.1002/stem.1426
Autor:
Xinzhi Zhou, Aliaksandra Radzisheuskaya, Anna Waterhouse, Andrew J.H. Smith, Chia-Yi Lin, Guillaume Blin, Jessica Taube, Owen R. Davies, Sally Lowell
Publikováno v:
Cell Reports
Davies, O R, Lin, C-Y, Radzisheuskaya, A, Zhou, X, Taube, J, Blin, G, Waterhouse, A, Smith, A & Lowell, S 2013, ' Tcf15 Primes Pluripotent Cells for Differentiation ', Cell Reports, vol. 3, no. 2, pp. 472-484 . https://doi.org/10.1016/j.celrep.2013.01.017
Cell Reports, Vol 3, Iss 2, Pp 472-484 (2013)
Davies, O R, Lin, C-Y, Radzisheuskaya, A, Zhou, X, Taube, J, Blin, G, Waterhouse, A, Smith, A & Lowell, S 2013, ' Tcf15 Primes Pluripotent Cells for Differentiation ', Cell Reports, vol. 3, no. 2, pp. 472-484 . https://doi.org/10.1016/j.celrep.2013.01.017
Cell Reports, Vol 3, Iss 2, Pp 472-484 (2013)
Summary The events that prime pluripotent cells for differentiation are not well understood. Inhibitor of DNA binding/differentiation (Id) proteins, which are inhibitors of basic helix-loop-helix (bHLH) transcription factor activity, contribute to pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94402b93065527350227d41945bd06ac
http://europepmc.org/articles/PMC3607254
http://europepmc.org/articles/PMC3607254
Autor:
F. Marques-Kranc, Jim R. Hughes, Doug Higgs, Jacqueline A. Sharpe, M. Richardson, F. Luna de Crespo, Andrew J.H. Smith, Helen Wallace, William G. Wood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec88ab4d2484f0f82f6e62b97b33e78
https://ora.ox.ac.uk/objects/uuid:d56a1ecf-f275-4a49-953e-cd0ecd5aed66
https://ora.ox.ac.uk/objects/uuid:d56a1ecf-f275-4a49-953e-cd0ecd5aed66