Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andrew J. Whitehead"'
Publikováno v:
Green Chemistry. 19:503-510
Halogenated derivatives of phenylalanine can be used as cross-coupling reagents for making drug-like molecules, and pure enantiomers of these precursors are therefore highly desirable. In our exploration of enzymatic routes to simplify the deracemisa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfed3715083b9eccb8b0ef4a28e63c49
https://doi.org/10.1039/c6gc01922f
https://doi.org/10.1039/c6gc01922f
Autor:
Jiasheng Guo, Marie-Catherine Salaun, Greg A. Erickson, Andrew J. Whitehead, Mark B. Mitchell, Mike McClure
Publikováno v:
Tetrahedron Letters. 55:6007-6010
A new synthesis of Lapatinib, an orally active drug for breast cancer, is described. The synthesis involves a palladium catalyzed regioselective arylation of furfural with 6-bromo- N -(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine. This k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::962e940558ea8b2b56c059b639aa41f0
https://doi.org/10.1016/j.tetlet.2014.09.039
https://doi.org/10.1016/j.tetlet.2014.09.039
Autor:
Nathalie Langlade, John M. Northall, Alastair J. Roberts, Jonathan P. Graham, Andrew J. Whitehead
Publikováno v:
Organic Process Research & Development. 15:44-48
An efficient and scalable synthesis of a glycine transporter inhibitor is presented. The key steps in the synthetic sequence are the formation of a spirocyclic imidazolidinone from an α-amino nitrile and a cyclic ketone and an arylation of 4-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44c3632936aef3455f590a75266bc337
https://doi.org/10.1021/op100210s
https://doi.org/10.1021/op100210s
Publikováno v:
Tetrahedron. 60:2673-2692
The rhodium (I) catalysed tandem hydrosilylation-intramolecular aldol reaction provides a simple strategy for construction of a range of usefully functionalised five-membered rings from readily prepared 6-oxo-2-hexenoates in good yield and with good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb94a6fe1342a7ec63d2b34b8165d15c
https://doi.org/10.1016/j.tet.2003.12.057
https://doi.org/10.1016/j.tet.2003.12.057
Autor:
Andrew J. Whitehead, Nigel S. Simpkins, Robert J. Outram, Alexander J. Blake, Christopher L. Friend
Publikováno v:
Tetrahedron Letters. 42:2877-2881
The reaction of silylketenes with thiophenol, mediated by cinchona alkaloid catalysts, proceeds to give α-silylthioester products in good chemical yield and with enantiomeric excess values in the range 79–93%. The absolute configuration of one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0273695f741cc47d1a91edc9d1800e0
https://doi.org/10.1016/s0040-4039(01)00304-5
https://doi.org/10.1016/s0040-4039(01)00304-5
Stereospecific construction of substituted piperidines. Synthesis of (−)-paroxetine and (+)-laccarin
Publikováno v:
Chem. Commun.. :728-730
Short and efficient enantioselective syntheses of (–)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2090e969b8b503549184bec39031aa90
https://doi.org/10.1039/b617260a
https://doi.org/10.1039/b617260a
Autor:
Paula J. O'Leary, Michelle Hastings, Philip W. Howard, Patrick McArdle and, James A. S. Howell, Desmond Cunningham, and David A. Owen, and Andrew G. Bell, Andrew J. Whitehead, G. Richard Stephenson
Publikováno v:
Organometallics. 15:4247-4257
A variety of cyclic and acyclic [(pentadienyl)Fe(CO)2L]X complexes (L = CO, PPh3) containing terminal acyloxy or alkoxy substituents have been prepared. In situ NMR studies indicate that for the acyclic series where L = CO, stability is limited by so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b26314a6641919778c7f855afca6b601
https://doi.org/10.1021/om960336a
https://doi.org/10.1021/om960336a
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1a35f0a43cf885024a97e86683bbbb
https://doi.org/10.1002/chin.199147232
https://doi.org/10.1002/chin.199147232
Autor:
Catherine Mills, Andrew J. Whitehead, David Emiabata‐Smith, William B. Motherwell, A. Mckillop
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c42ed0ff88e9823958854f1a61aafa53
https://doi.org/10.1002/chin.200145054
https://doi.org/10.1002/chin.200145054
Autor:
Andrew J. Whitehead, Trevor F. Page
Publikováno v:
Thin Solid Films. 220:277-283
In this paper we report the results of ultralow load indentation (“nanoindentation”) tests carried out on a range of thin film coated systems. In addition to characterizing the properties of each system at high resolutions, a further principal ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea23aa2a109cab96a362ccb4c05852a0
https://doi.org/10.1016/0040-6090(92)90585-y
https://doi.org/10.1016/0040-6090(92)90585-y