Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew J. Walz"'
Organic impurity profiling of fentanyl samples associated with recent clandestine laboratory methods
Autor:
Steven G. Toske, Jennifer R. Mitchell, James M. Myslinski, Andrew J. Walz, David B. Guthrie, Elizabeth M. Guest, Charlotte A. Corbett, Emily D. Lockhart
Publikováno v:
Journal of Forensic Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0283402882eb73cf26fb1753d2032f
https://doi.org/10.1111/1556-4029.15281
https://doi.org/10.1111/1556-4029.15281
Autor:
Li Kong, Andrew J. Walz
Publikováno v:
Toxicology Letters. 369:22-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4794a0aede6b2a8c2a8b73f4c2c8e97b
https://doi.org/10.1016/j.toxlet.2022.08.001
https://doi.org/10.1016/j.toxlet.2022.08.001
Identification of human cytochrome P450 isozymes involved in the oxidative metabolism of carfentanil
Autor:
Li Kong, Andrew J Walz
Publikováno v:
Toxicology Letters. 343:28-33
Carfentanil is an ultra-potent opioid with an analgesic potency 10,000 times that of morphine but has received little scientific investigation. In the present study, the human cytochrome P450 (CYP) isozymes catalyzing the oxidative metabolism of carf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8171f2fc393840fd33479d8d055d423a
https://doi.org/10.1016/j.toxlet.2021.02.017
https://doi.org/10.1016/j.toxlet.2021.02.017
Autor:
Li Kong, Andrew J. Walz
Publikováno v:
Toxicology letters. 367
Carfentanil, a µ-opioid receptor (MOR) agonist with an analgesic potency 10,000 times that of morphine, is extensively metabolized to norcarfentanil (M1), 4-Piperidinecarboxylic acid, 1-(2-hydroxy-2-phenylethyl)-4-[(1-oxopropyl)phenylamino]-, methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c689a04f37264cd66dc780b792297a99
https://pubmed.ncbi.nlm.nih.gov/35835351
https://pubmed.ncbi.nlm.nih.gov/35835351
Autor:
Li Kong, Andrew J Walz
Publikováno v:
Forensic Toxicology. 38:352-364
The metabolism of carfentanil was assessed using human, dog, and rat pulmonary microsomes. Mass spectrometry based analysis allowed for metabolite identification and species differentiation. Participation of different metabolic enzymes in carfentanil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98632315a4e44ea60cb2ac46b17ca599
https://doi.org/10.1007/s11419-019-00521-x
https://doi.org/10.1007/s11419-019-00521-x
Autor:
James M. Myslinski, Christopher M. Timperley, Nicholas J. Cooper, Fu-Lian Hsu, Neil Roughley, Li Kong, Andrew J Walz, Tyler D. P. Goralski, Tim Rose, Michael G. Feasel
Publikováno v:
ACS Med Chem Lett
[Image: see text] Carfentanil is a synthetic opioid significantly more potent than clinically prescribed fentanyl. The primary metabolites of carfentanil, generated from human liver microsomes, were structurally confirmed through chemical synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80f1787a3271f7f3fe0503bf41ab87f
https://doi.org/10.1021/acsmedchemlett.9b00404
https://doi.org/10.1021/acsmedchemlett.9b00404
Publikováno v:
Synthesis. 51:2891-2896
N-Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5cee6885483ab7067ce48560cecd62
https://doi.org/10.1055/s-0037-1611836
https://doi.org/10.1055/s-0037-1611836
Autor:
S.M. Bester, Scott D. Pegan, J.R. McGuire, Fu-Lian Hsu, J.J. Height, Su Y Bae, Andrew J. Walz, Dana R. Anderson
Publikováno v:
ACS Med Chem Lett
[Image: see text] The threat of a deliberate release of chemical nerve agents has underscored the need to continually improve field effective treatments for these types of poisonings. The oxime containing HLö-7 is a potential second-generation thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fc384ebb22fe2d4e4eda8329b8170b
https://doi.org/10.1021/acsmedchemlett.9b00021
https://doi.org/10.1021/acsmedchemlett.9b00021
Autor:
Fu-Lian Hsu, Andrew J. Walz
Publikováno v:
Organic Preparations and Procedures International. 49:467-470
Fentanyl is a synthetic opioid developed by Janssen and co-workers over 40 years ago and is currently used for chronic pain management.1 The medical importance of fentanyl has inspired synthetic in...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc807565d56471a0a6cc54f9c9edc477
https://doi.org/10.1080/00304948.2017.1374129
https://doi.org/10.1080/00304948.2017.1374129
Autor:
Adam Uzieblo, Dirk M. Zajonc, Tan-Yun Cheng, Yanping Xu, Gregory W. Endres, Garrett C. Moraski, Catherine E. Costello, Jingdan Hu, D. Branch Moody, Marvin J. Miller, Andrew J. Walz, Anne Kasmar, David C. Young
Publikováno v:
Journal of Biological Chemistry. 284:25087-25096
Mycobacterium tuberculosis survival in cells requires mycobactin siderophores. Recently, the search for lipid antigens presented by the CD1a antigen-presenting protein led to the discovery of a mycobactin-like compound, dideoxymycobactin (DDM). Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bd5f89487fa2e95c0bae8d0848a814
https://doi.org/10.1074/jbc.m109.000802
https://doi.org/10.1074/jbc.m109.000802