Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrew J. Trease"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6441 (2024)
Mitochondrial quality control is essential in mitochondrial function. To examine the importance of Parkin-dependent mechanisms in mitochondrial quality control, we assessed the impact of modulating Parkin on proteome flux and mitochondrial function i
Externí odkaz:
https://doaj.org/article/c7045d72051f4815ba068021f646a872
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 660 (2023)
T and B cell receptor signaling involves the activation of Akt, MAPKs, and PKC as well as an increase in intracellular Ca2+ and calmodulin activation. While these coordinate the rapid turnover of gap junctions, also implicated in this process is Src,
Externí odkaz:
https://doaj.org/article/ca4e6287d7904ee98f790ee79334e352
Autor:
Andrew J. Trease, Joseph W. George, Nashanthea J. Roland, Eliezer Z. Lichter, Katy Emanuel, Steven Totusek, Howard S. Fox, Kelly L. Stauch
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neurogenerative disorders, such as Alzheimer’s disease (AD), represent a growing public health challenge in aging societies. Tauopathies, a subset of neurodegenerative disorders that includes AD, are characterized by accumulation of fibrillar and h
Externí odkaz:
https://doaj.org/article/4ff4202ef63f4462963ca041402bc086
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1428 (2018)
Connexins are integral membrane building blocks that form gap junctions, enabling direct cytoplasmic exchange of ions and low-molecular-mass metabolites between adjacent cells. In the heart, gap junctions mediate the propagation of cardiac action pot
Externí odkaz:
https://doaj.org/article/c09e4a99a6df4ab29af476fb4e831bdf
Autor:
Gaelle Spagnol, Andrew J. Trease, Li Zheng, Mirtha Gutierrez, Ishika Basu, Cleofes Sarmiento, Gabriella Moore, Matthew Cervantes, Paul L. Sorgen
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1562 (2018)
Activation of Wnt signaling induces Connexin43 (Cx43) expression via the transcriptional activity of β-catenin, and results in the enhanced accumulation of the Cx43 protein and the formation of gap junction channels. In response to Wnt signaling, β
Externí odkaz:
https://doaj.org/article/ecf6cca60c9241efae8bb4ce621fb0dd
Autor:
Andrew J, Trease, Meng, Niu, Brenda, Morsey, Chittibabu, Guda, Siddappa N, Byrareddy, Shilpa, Buch, Howard S, Fox
Publikováno v:
Journal of Leukocyte Biology. 112:969-981
Microglia and macrophages are essential for homeostatic maintenance and innate immune response in the brain. They are the first line of defense against infections such as HIV/SIV in the brain. However, they are susceptible to infection and function a
BackgroundA consequence of an aging society is a continual and dramatic increase in the number of patients suffering from tauopathies, including Alzheimer’s disease (AD) and certain frontotemporal dementias. Accumulation of intracellular inclusions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ff55d0ddcce670eed87b141ecf907e0
https://doi.org/10.21203/rs.3.rs-183974/v1
https://doi.org/10.21203/rs.3.rs-183974/v1
Autor:
Bin Duan, Wen Shi, Hanjun Li, Kaushik P. Patel, Li Zheng, Andrew J. Trease, Gaelle Spagnol, Paul L. Sorgen, Kenichi Katsurada
Publikováno v:
J Mol Cell Cardiol
Identification of proteins that interact with Cx43 has been instrumental in the understanding of gap junction (GJ) regulation. An in vitro phosphorylation screen identified that Protein tyrosine kinase 2 beta (Pyk2) phosphorylated purified Cx43CT and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb05077c0c8b958f74b19ca8b10779b
https://europepmc.org/articles/PMC7736531/
https://europepmc.org/articles/PMC7736531/
Autor:
Jorge E. Contreras, Andrew L. Harris, Paul L. Sorgen, Juan M. Valdez Capuccino, Andrew J. Trease
Publikováno v:
Journal of Molecular and Cellular Cardiology. 111:69-80
Gap junctions, composed of connexins, mediate electrical coupling and impulse propagation in the working myocardium. In the human heart, the spatio-temporal regulation and distinct functional properties of the three dominant connexins (Cx43, Cx45, an
Gap junctions are intercellular conduits that permit the passage of ions, small metabolites, and signaling molecules between cells. Connexin32 (Cx32) is a major gap junction protein in the liver and brain. Phosphorylation is integral to regulating co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae4bab85860371e45286e69658619f4
https://europepmc.org/articles/PMC6322898/
https://europepmc.org/articles/PMC6322898/