Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Andrew J. Theobald"'
Autor:
Concepción Cid, Iván Caballero, Gonzalo Colmenarejo, Francisco-Javier Gamo, Isabel Coma, Daniel Thomas, Martin Hibbs, Amy L Bass, Andrew J. Theobald
Publikováno v:
Biochemistry. 51:4764-4771
Plasmodium falciparum is the most prevalent and deadly species of the human malaria parasites, and thioredoxin reductase (TrxR) is an enzyme involved in the redox response to oxidative stress. Essential for P. falciparum survival, the enzyme has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f68d67c5758282511274238784053c9
https://doi.org/10.1021/bi3005076
https://doi.org/10.1021/bi3005076
Autor:
Michael N. Gwynn, Jianzhong Huang, Martin Hibbs, Claus Spitzfaden, Jason Pizzollo, Haifeng Cui, Velupillai Srikannathasan, Robert Tanner, Karen A. Ingraham, Robert A. Stavenger, Pan F. Chan, Minghua Gu, Carol Shen, Paul Homes, Andrew J. Theobald, Andrew P. Fosberry, Anthony Shillings, Michael M. Hann, Benjamin D. Bax
Publikováno v:
Nature Communications
New antibacterials are needed to tackle antibiotic-resistant bacteria. Type IIA topoisomerases (topo2As), the targets of fluoroquinolones, regulate DNA topology by creating transient double-strand DNA breaks. Here we report the first co-crystal struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b4c3994d8361a48efe0cd59325b97
https://doi.org/10.1038/ncomms10048
https://doi.org/10.1038/ncomms10048
Autor:
Claus Spitzfaden, Paul Homes, Andrew P. Fosberry, Jianzhong Huang, Martin Hibbs, Michael N. Gwynn, Anthony Shillings, Alexandre Wohlkonig, Andrew J. Theobald, Pan F. Chan, Velupillai Srikannathasan, Onkar M. P. Singh, Benjamin D. Bax
Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double-stranded DNA breaks created by bacterial type IIA topoisomerases. Previous crystal structures of Staphylococcus aureus DNA gyrase with asymmetric DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab10eeb8df12cca74374d1610c9aeae7
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
Autor:
Benjamin D. Bax, Pan F. Chan, Michael M. Hann, Michael N. Gwynn, Daniel R. Gentry, Ceri J. Lewis, Jo J. Jones, Claus Spitzfaden, Andrew P. Fosberry, Martin Hibbs, Earl May, Kristin K. Brown, Alexandre Wohlkonig, Drake S. Eggleston, Onkar M. P. Singh, Alan Joseph Hennessy, Andrew J. Theobald, Fabrice Gorrec, Martin R. Saunders, Anthony Shillings, Emma J. Jones, Carol Shen, Neil D. Pearson, Jianzhong Huang, Ilaria Giordano
Despite the success of genomics in identifying new essential bacterial genes, there is a lack of sustainable leads in antibacterial drug discovery to address increasing multidrug resistance. Type IIA topoisomerases cleave and religate DNA to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea159ed95a9dbead771494c8d86bdb2
https://doi.org/10.1038/nature09197
https://doi.org/10.1038/nature09197
Autor:
Andrew J. Theobald, Pan F. Chan, Namir J. Hassan, Kathleen T. Gallagher, Delfina C. Segura, Daniel Thomas, Praveen Kumar Singh, Maria-Jesus Vazquez, Martin Hibbs
Publikováno v:
Protein expression and purification. 76(2)
DNA topoisomerase type II enzymes are well-validated targets of anti-bacterial and anti-cancer compounds. In order to facilitate discovery of these types of inhibitors human topoisomerase II in vitro assays can play an important role to support drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f608b96fc766d891436de8729ac7cbe3
https://pubmed.ncbi.nlm.nih.gov/20709174
https://pubmed.ncbi.nlm.nih.gov/20709174
Autor:
Alexandre Wohlkonig, Michael N. Gwynn, Kristin K. Koretke, Jianzhong Huang, Emma J. Jones, Neil D. Pearson, Ben Bax, Andrew P. Fosberry, Martin Hibbs, Claus Spitzfaden, Andrew J. Theobald, Anthony Shillings
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 65:s25-s25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0021294a143addc99e3b6cc83563b5cb
https://doi.org/10.1107/s0108767309099565
https://doi.org/10.1107/s0108767309099565