Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Andrew J. Skelton"'
1
Akademický článek
DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation
Autor: Rodolfo Gómez, Matt J. Barter, Ana Alonso-Pérez, Andrew J. Skelton, Carole Proctor, Gabriel Herrero-Beaumont, David A. Young
Publikováno v: Biological Research, Vol 56, Iss 1, Pp 1-17 (2023)
Abstract Background Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-methylation changes du
Externí odkaz: https://doaj.org/article/d05b15634531419289d5e5b613947160
Zobrazit plný text záznamu
2
Akademický článek
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function
Autor: Laura A. Ridgley, Amy E. Anderson, Nicola J. Maney, Najib Naamane, Andrew J. Skelton, Catherine A. Lawson, Paul Emery, John D. Isaacs, Ruaidhrí J. Carmody, Arthur G. Pratt
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA). We tested the hypothesi
Externí odkaz: https://doaj.org/article/d6826c2d6c3648cca5ebf95c8b0cac85
Zobrazit plný text záznamu
3
Isolation and next generation sequencing of archival formalin‐fixed DNA
Autor: Ahlam Alqahtani, Lorraine Eley, Bill Chaudhry, Srinivas Annavarapu, Andrew J. Skelton, Deborah J. Henderson
Publikováno v: Journal of Anatomy
DNA from archived organs is presumed unsuitable for genomic studies because of excessive formalin‐fixation. As next generation sequencing (NGS) requires short DNA fragments, and Uracil‐N‐glycosylase (UNG) can be used to overcome deamination, th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dc70cb505e225eb2dba7c0c6c19da6
http://europepmc.org/articles/PMC7476199
Zobrazit plný text záznamu
5
DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions
Autor: Rodolfo Gómez, David Young, Hannah R Elliott, Louise N. Reynard, Andrew J. Skelton, Julia Falk, Matt J. Barter, Kathleen Cheung, Catherine Bui
Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-58093-5⟩
Barter, M J, Bui, C, Cheung, K, Falk, J, Gómez, R, Skelton, A J, Elliott, H R, Reynard, L N & Young, D A 2020, ' DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions ', Scientific Reports, vol. 10, 1169 (2020) . https://doi.org/10.1038/s41598-020-58093-5
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation. Methylation changes may also play a key role in lineage specification during stem cell differentiation. To further our
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d354a28bf7d8693992d9cae8e041f
https://hal.univ-lorraine.fr/hal-02949383
Zobrazit plný text záznamu
6
O11 Lymphocyte DNA methylation mediates genetic risk at RA risk loci that are shared with other immune mediated diseases
Autor: Anne Barton, Arthur G. Pratt, Louise N. Reynard, Julie Diboll, Nisha Nair, Alexander D. Clark, Amy E. Anderson, Andrew J. Skelton, Stephen Eyre, John D. Isaacs, Najib Naamane, Nishanthi Thalayasingam
Publikováno v: Rheumatology. 59
Background The aetiology of rheumatoid arthritis (RA) is complex. In particular, the vast majority of disease-associated variants implicated by genome-wide association studies are non-coding, leaving genetic mechanisms of adaptive immune dysregulatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c48252ff326a2950f50ceca433278e54
https://doi.org/10.1093/rheumatology/keaa110.010
Zobrazit plný text záznamu
7
microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs
Autor: Katarzyna A. Piróg, Robert M. Jackson, Tamas Dalmay, Matt J. Barter, Dimitra Tsompani, Sarah Charlton, Andrew J. Skelton, David Young, Kathleen Cheung, Tracey E. Swingler, Jamie Soul, Ian M. Clark, Louise N. Reynard, N. Crowe, Yao Hao, Steven Woods, Colin G. Miles
Publikováno v: Woods, S, Charlton, S, Cheung, K, Hao, Y, Soul, J, Reynard, L N, Crowe, N, Swingler, T E, Skelton, A J, Piróg, K A, Miles, C G, Tsompani, D, Jackson, R M, Dalmay, T, Clark, I M, Barter, M J & Young, D A 2020, ' microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs ', RNA (New York, N.Y.) . https://doi.org/10.1261/rna.075176.120
RNA
MiR-140 is selectively expressed in cartilage. Deletion of the entire miR-140 locus in mice results in growth retardation and early-onset osteoarthritis-like pathology, however the relative contribution of miR-140-5p or miR-140-3p to the phenotype re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640a49e1e7871988538477c18d056f34
https://www.research.manchester.ac.uk/portal/en/publications/micrornaseq-of-cartilage-reveals-an-overabundance-of-mir1403p-which-contains-functional-isomirs(25abf5c9-f846-4858-b0ae-09f5d2f6babb).html
Zobrazit plný text záznamu
8
Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2
Autor: Katrina M Wood, Stephania Bitetti, Mohammed Zarhrate, Rafiqul Hussain, Vicky Brocklebank, Meghan Acres, Vincent Bondet, Ruyue Sun, Tracy A Briggs, Rui Chen, John H. Livingston, Richard E. Randall, Robert Wynn, Claire L. Harris, Darragh Duffy, Cécile Fourrage, Florian Gothe, Christopher J A Duncan, Sophie Hambleton, Stephen M. Hughes, Karin R. Engelhardt, Julija Pavaine, Leo A. H. Zeef, Jonathan Coxhead, Dan F. Young, Yanick J. Crow, Aneta Mikulasova, Victoria G. Shuttleworth, Bronte M. Corner, Gillian I. Rice, Edmund Cheesman, Barbara A. Innes, Ronnie Wright, David J. Kavanagh, Angela Grainger, Simon C. Lovell, Andrew J. Skelton, Benjamin J. Thompson
Publikováno v: Rice, G, Lovell, S, Pavaine, J, Wright, R, Zeef, L, Hambleton, S, Briggs, T & et al. 2019, ' Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 ', Science Immunology, vol. 4, no. 42, eaav7501 . https://doi.org/10.1126/sciimmunol.aav7501
Duncan, C J A, Thompson, B, Chen, R, Rice, G I, Gothe, F, Young, D F, Lovell, S C, Shuttleworth, V G, Brocklebank, V, Corner, B, Skelton, A J, Bondet, V, Coxhead, J, Duffy, D, Fourrage, C, Livingston, J H, Pavaine, J, Cheesman, E, Bitetti, S, Grainger, A, Acres, M, Innes, B A, Mikulasova, A, Sun, R, Hussain, R, Wright, R, Wynn, R, Zarhrate, M, Zeef, L A H, Wood, K M, Hughes, S M, Harris, C L, Engelhardt, K R, Crow, Y, Randall, R E, Kavanagh, D, Hambleton, S & Briggs, T A 2019, ' Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 ', Science Immunology . https://doi.org/10.1126/sciimmunol.aav7501
Science Immunology
Science Immunology, 2019, 4 (42), pp.eaav7501. ⟨10.1126/sciimmunol.aav7501⟩
Science Immunology, American Association for the Advancement of Science, 2019, 4 (42), pp.eaav7501. ⟨10.1126/sciimmunol.aav7501⟩
International audience; Excessive type I interferon (IFNα/β) activity is implicated in a spectrum of human disease, yet its direct role remains to be conclusively proven. We investigated two siblings with severe early-onset autoinflammatory disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75b99ad822c9b4f4b821ead0cffb9e2
https://pure.manchester.ac.uk/ws/files/149146089/aav7501_ArticleContent_preedit_CD_clean.docx
Zobrazit plný text záznamu
9
Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in TNFAIP3 (A20)
Autor: Jonathan Coxhead, Joseph D. P. Willet, Karin R. Engelhardt, Andrew J. Cant, Sophie Hambleton, Veena Zamvar, Christopher J A Duncan, Julian Thomas, Rachel Theobald, David J. Swan, Mary Slatter, Angela Grainger, Matthew F. Thomas, Rafiqul Hussain, Andrew J. Skelton, Emma Dinnigan
Publikováno v: Annals of the Rheumatic Diseases
Rare Mendelian disorders increasingly contribute to our understanding of the genetic architecture of autoimmune disease and the key molecular pathways governing its pathogenesis. Early-onset autoimmune disease can arise through activating mutations i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c200f942ed8323b20342bcaa0440ffbd
http://europepmc.org/articles/PMC5909743
Zobrazit plný text záznamu
10
AB0024 WHOLE BLOOD ENDOGENOUS RETROELEMENT ACTIVITY ASSOCIATES WITH ANTI-CCP TITRES IN EARLY DRUG NAïVE RA AND IS PREFERENTIALLY INCREASED IN CD5+ AND NAïVE B CELLS
Autor: Andrew J. Skelton, Catharien M. U. Hilkens, John D. Isaacs, Arthur G. Pratt, Gemma Vidal Pedrola, Faye A. H. Cooles, Najib Naamane, Ruchi Shukla, Amy E. Anderson
Publikováno v: Abstracts Accepted for Publication.
Background Endogenous retroelements of which LINE1, Alu and LTR are the main subsets, constitute approximately 50% of the human genome. They are mobile genetic elements derived from the historical genomic integration of retroviruses. Whilst most are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::538cdfc828bd7d2d90b9e9beaa279fcb
https://doi.org/10.1136/annrheumdis-2019-eular.2980
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje