Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andrew J. Simnick"'
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
PDF file - 83K, Citation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e66045944b81cc05c5d9096f9c12db
https://doi.org/10.1158/0008-5472.22393964.v1
https://doi.org/10.1158/0008-5472.22393964.v1
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
AVI file - 34.5MB, Real-time intravascular release of doxorubicin from Dox-TSL and subsequent redistribution of drug in B16 melanoma tumor tissue. The video shows drug (red) delivered over the first 20min, at 20x magnification. The eNOS-GFPtg mouse m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7566102854984d337f797e7992c274
https://doi.org/10.1158/0008-5472.22393952
https://doi.org/10.1158/0008-5472.22393952
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
AVI file - 41.7MB, Real-time drug delivery of free doxorubicin and Dox-TSL in heated FaDu tumor tissue. The blood vessels are highlighted in green and drug is red. The video shows drug delivered over the first 20min, at 20x magnification. Free drug q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47626bdd01973a44e087fcf05cac1f41
https://doi.org/10.1158/0008-5472.22393958
https://doi.org/10.1158/0008-5472.22393958
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b119116676ac980f585d26c62d68ae6d
https://doi.org/10.1158/0008-5472.c.6503915.v1
https://doi.org/10.1158/0008-5472.c.6503915.v1
Autor:
Ashutosh Chilkoti, Miriam Amiram, Gabi Hanna, Wenge Liu, Mark W. Dewhirst, Christopher D. Kontos, Andrew J. Simnick
Publikováno v:
Journal of Controlled Release. 155:144-151
Antivascular targeting is a promising strategy for tumor therapy. This strategy has the potential to overcome many of the transport barriers associated with targeting tumor cells in solid tumors, because the tumor vasculature is directly accessible t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b67faa6913b3b5b748e94e48b65c6e
https://doi.org/10.1016/j.jconrel.2011.06.044
https://doi.org/10.1016/j.jconrel.2011.06.044
Autor:
Andrew J. Simnick, Wenge Liu, Jonathan R. McDaniel, J. Andrew MacKay, Ashutosh Chilkoti, Mingnan Chen
Publikováno v:
Nature materials
New strategies to self-assemble biocompatible materials into nanoscale, drug-loaded packages with improved therapeutic efficacy are needed for nanomedicine. To address this need, we developed artificial recombinant chimeric polypeptides (CPs) that sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0a21edbe81a1bd5cf5c5ea1475b36d
https://doi.org/10.1038/nmat2569
https://doi.org/10.1038/nmat2569
Publikováno v:
Polymer Reviews. 47:121-154
Elastin‐like polypeptides (ELPs) are a unique class of genetically encoded biopolymers with tunable thermosensitivity and biocompatibility. This review provides an introduction to ELPs and an overview of their design and synthesis. It also discusse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236f2466b7fc6d36be0560bcfecfa59b
https://doi.org/10.1080/15583720601109594
https://doi.org/10.1080/15583720601109594
Autor:
Timo L.M. ten Hagen, Matthew R. Dreher, Ashley A. Manzoor, Gerben A. Koning, Andrew J. Simnick, Chelsea D. Landon, Ashutosh Chilkoti, Lars H. Lindner, Shiva K. Das, Ji-Young Park, Mark W. Dewhirst, David Needham, Won Soon Park, Gabi Hanna
Publikováno v:
Cancer Res. 72, 5566-5575 (2012)
Cancer Research, 72(21), 5566-5575. American Association for Cancer Research Inc.
Cancer Research, 72(21), 5566-5575. American Association for Cancer Research Inc.
Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ace0013612fcb871959185cb37238e7
https://pubmed.ncbi.nlm.nih.gov/22952218
https://pubmed.ncbi.nlm.nih.gov/22952218
Autor:
Ryan T. Hill, Andres Garcia, Robert L. Clark, Angus Hucknall, Matthew S. Johannes, Stefan Zauscher, Ashutosh Chilkoti, Buddy D. Ratner, Andrew J. Simnick
Publikováno v:
Biointerphases. 4(2)
In this article, the authors describe new approaches to synthesize and pattern surfaces with poly[oligo(ethylene glycol) methyl methacrylate] (POEGMA) polymer brushes synthesized by surface-initiated atom transfer radical polymerization. These patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc750bef6f8d5eec39ef404e9274f9ca
https://pubmed.ncbi.nlm.nih.gov/20408717
https://pubmed.ncbi.nlm.nih.gov/20408717
Multivalency is the increase in avidity resulting from the simultaneous interaction of multiple ligands with multiple receptors. This phenomenon, seen in antibody-antigen and virus-cell membrane interactions, is useful in designing bioinspired materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc6fb128dcb5d2537d72de9a157a5ed