Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andrew J. Perrett"'
Autor:
Lindsay D. Smith, Rachel L. Dickinson, Christian M. Lucas, Alex Cousins, Alexey A. Malygin, Carika Weldon, Andrew J. Perrett, Andrew R. Bottrill, Mark S. Searle, Glenn A. Burley, Ian C. Eperon
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 193-205 (2014)
Summary: The use of oligonucleotides to activate the splicing of selected exons is limited by a poor understanding of the mechanisms affected. A targeted bifunctional oligonucleotide enhancer of splicing (TOES) anneals to SMN2 exon 7 and carries an e
Externí odkaz:
https://doaj.org/article/bf41ff253e044eda890bb9bba4041f21
Autor:
Rachel L. Dickinson, Andrew J. Perrett, Glenn A. Burley, Ian C. Eperon, Mathias Brust, Helen Lewis, Zeljka Krpetic
Publikováno v:
Chem. Sci.. 4:257-265
Since alternative splicing patterns are exhibited by most mammalian genes, the functional properties of a gene may be changed for therapeutic purposes by nudging splicing from one pattern to another. Splicing to a refractory exon can be enhanced usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5e7f1790155f8f4a61f796f5a6c1981
https://doi.org/10.1039/c2sc20937c
https://doi.org/10.1039/c2sc20937c
Autor:
Lindsay D, Smith, Rachel L, Dickinson, Christian M, Lucas, Alex, Cousins, Alexey A, Malygin, Carika, Weldon, Andrew J, Perrett, Andrew R, Bottrill, Mark S, Searle, Glenn A, Burley, Ian C, Eperon
Publikováno v:
Cell Reports
Summary The use of oligonucleotides to activate the splicing of selected exons is limited by a poor understanding of the mechanisms affected. A targeted bifunctional oligonucleotide enhancer of splicing (TOES) anneals to SMN2 exon 7 and carries an ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8863182c9cab90f9bd6b5f4a3acce8e
https://pubmed.ncbi.nlm.nih.gov/25263560
https://pubmed.ncbi.nlm.nih.gov/25263560
Publikováno v:
Angewandte Chemie (International ed. in English). 51(39)
Out of the loop: Do the proteins bound to an enhancer site on pre-mRNA interact directly with the splice site by diffusion (looping), as is generally accepted, or does the intervening RNA play a role? By inserting a PEG linker between an enhancer seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc73a0b8e447ee626a5793c66a83531
https://pubmed.ncbi.nlm.nih.gov/22936639
https://pubmed.ncbi.nlm.nih.gov/22936639