Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Andrew J. Nicoll"'
Autor:
Claire J. Sarell, Emma Quarterman, Daniel C.-M. Yip, Cassandra Terry, Andrew J. Nicoll, Jonathan D. F. Wadsworth, Mark A. Farrow, Dominic M. Walsh, John Collinge
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrPC). Ligands that bind to PrPC can inhibit prion propagation and neurotoxi
Externí odkaz:
https://doaj.org/article/229b8c2701a0414b8a25fe465d116345
Autor:
Silvia A Purro, Michael Farmer, Elizabeth Noble, Claire J Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X Thomas, Mark Farrow, Andrew J Nicoll, Dominic Walsh, John Collinge
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294465 (2023)
Oligomers formed from monomers of the amyloid β-protein (Aβ) are thought to be central to the pathogenesis of Alzheimer's disease (AD). Unsurprisingly for a complex disease, current mouse models of AD fail to fully mimic the clinical disease in hum
Externí odkaz:
https://doaj.org/article/8af80f9aedd94ca28f2439779fee4821
Autor:
Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 22-31 (2017)
Abstract Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. Repea
Externí odkaz:
https://doaj.org/article/1f8b61ee6cea4757929c90eeb5c2d015
Autor:
Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Chun-Mun Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark A. Farrow, Andrew J. Nicoll, Dominic Walsh, John Collinge
The aggregation of amyloid-β (Aβ) monomers increases their neurotoxicity, and these oligomeric species are thought to be central to the pathogenesis of Alzheimer’s disease. Unsurprisingly for such a complex disease, current Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b5c337a832f741bf56d086ace8316cc
https://doi.org/10.1101/2022.09.25.508690
https://doi.org/10.1101/2022.09.25.508690
Publikováno v:
Biological Psychiatry. 83:358-368
The initial report that cellular prion protein (PrPC) mediates toxicity of amyloid-β species linked to Alzheimer's disease was initially treated with scepticism, but growing evidence supports this claim. That there is a high-affinity interaction is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b353d55a5d39ac27b758ec6ee9adcfc0
https://doi.org/10.1016/j.biopsych.2017.11.020
https://doi.org/10.1016/j.biopsych.2017.11.020
Publikováno v:
Biological psychiatry. 84(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b012a81ff1f599f34b755835e9f9907e
https://pubmed.ncbi.nlm.nih.gov/29752074
https://pubmed.ncbi.nlm.nih.gov/29752074
Autor:
Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W D
Publikováno v:
EMBO Molecular Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::00cb48e5b21aae38db11d8b7fa40305a
Autor:
A. Sarah Walker, Joanna Kenny, Matthew Ellis, Angela Richard-Loendt, John Collinge, Jonathan D. F. Wadsworth, Simon Mead, Zane Jaunmuktane, Andrew J. Nicoll, Sebastian Brandner, Peter Rudge, Francesca Launchbury, Jacqueline M. Linehan
Publikováno v:
Nature. 525:247-250
More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of treatment, typically in childhood, with human cadaveric pituitary-derived growth hormone contaminated with prions. Although such treatment ceased in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e94b2ed61cb6565af75e2d1b8bc3cc8
https://doi.org/10.1038/nature15369
https://doi.org/10.1038/nature15369
Autor:
Pietro Fratta, Karen Cleverley, Anny Devoy, Linda Partridge, Oliver Hendrich, Sebastian Grönke, Stuart Pickering-Brown, Andrew J. Nicoll, Frances E. Norona, Julian Pietrzyk, Thomas G. Moens, Ione O.C. Woollacott, Adrian M. Isaacs, Melissa Cabecinha, Elizabeth M. C. Fisher, Emma L. Clayton, Jacqueline Dols, Charlotte E. Ridler, Teresa Niccoli, Sarah Mizielinska
Publikováno v:
Science. 345:1192-1194
Dipeptide repeat peptides on the attack Certain neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), are associated with expanded dipeptides translated from RNA transcripts of disease-associated genes (see the Perspective by Wes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65038fd02fb5c543aac4a3d6b4ef83f8
https://doi.org/10.1126/science.1256800
https://doi.org/10.1126/science.1256800
Autor:
David James Miller, Klaus Fütterer, Rudolf Konrad Allemann, Raymond Ravelli, Andrew J. Nicoll
Publikováno v:
Journal of the American Chemical Society. 128:9187-9193
The design, synthesis, and characterization of a folded high-affinity metal-binding peptide is described. Based on the previously described folded peptide NTH-18, in which an alpha-helix was constrained through two disulfide bonds to a C-terminal ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd855ce29e2576a5baba34482cfd5b9a
https://doi.org/10.1021/ja061513u
https://doi.org/10.1021/ja061513u