Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Andrew J. Mouland"'
Autor:
Paola Guizar, Ana Luiza Abdalla, Anne Monette, Kristin Davis, Ramon Edwin Caballero, Meijuan Niu, Xinyun Liu, Oluwaseun Ajibola, Thomas T. Murooka, Chen Liang, Andrew J. Mouland
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110131- (2024)
Summary: HIV-1 hijacks host proteins involved in membrane trafficking, endocytosis, and autophagy that are critical for virus replication. Molecular details are lacking but are essential to inform on the development of alternative antiviral strategie
Externí odkaz:
https://doaj.org/article/00c18013ef8e4b1b99da5bbe44a51b53
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract A rapidly evolving understanding of phase separation in the biological and physical sciences has led to the redefining of virus-engineered replication compartments in many viruses with RNA genomes. Condensation of viral, host and genomic and
Externí odkaz:
https://doaj.org/article/2b3131c6eb6e4580813c2201d0cadfae
Publikováno v:
Viruses, Vol 16, Iss 2, p 229 (2024)
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently infected cells. These cells are considered viral reservoirs from
Externí odkaz:
https://doaj.org/article/df5a0a60ff7544df80d37c45e2ec990c
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111968- (2023)
Summary: The leap of retroviruses and coronaviruses from animal hosts to humans has led to two ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus nucleocapsid proteins have been studied extensively as potential dru
Externí odkaz:
https://doaj.org/article/db11f86f37e44461a338e623f582834d
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression. The role of the host mRNA decay
Externí odkaz:
https://doaj.org/article/d2077e7aa6ca4dc5936756c42b995169
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-20 (2018)
Abstract Background The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency. RNA surveillance pr
Externí odkaz:
https://doaj.org/article/8103aceba0af43ceaad504f915a2baa6
Autor:
Alessandro Cinti, Valerie Le Sage, Miroslav P. Milev, Fernando Valiente-Echeverría, Christina Crossie, Marie-Joelle Miron, Nelly Panté, Martin Olivier, Andrew J. Mouland
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking machineries for protein s
Externí odkaz:
https://doaj.org/article/12b9328987c2422886cdbc8d51c8c04b
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-14 (2017)
Externí odkaz:
https://doaj.org/article/f217e09fbe1b410fbc1c9fc16ada5a02
Autor:
Jessica Bellmann, Anne Monette, Vadreenath Tripathy, Anna Sójka, Masin Abo-Rady, Antje Janosh, Rajat Bhatnagar, Marc Bickle, Andrew J. Mouland, Jared Sterneckert
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Amyotrophic lateral sclerosis (ALS) arises from an interplay of genetic mutations and environmental factors. ssRNA viruses are possible ALS risk factors, but testing their interaction with mutations such as in FUS, which encodes an RNA-binding protei
Externí odkaz:
https://doaj.org/article/299cb5953bf049f1b298044b489abc73
Autor:
Anne Monette, Andrew J. Mouland
Publikováno v:
Viruses, Vol 12, Iss 10, p 1179 (2020)
Liquid-liquid phase separation (LLPS) is a rapidly growing research focus due to numerous demonstrations that many cellular proteins phase-separate to form biomolecular condensates (BMCs) that nucleate membraneless organelles (MLOs). A growing repert
Externí odkaz:
https://doaj.org/article/238dc0bec26346fb832beaeb2b69ff19