Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Andrew J. Mannes"'
Autor:
Bradford E. Hall, Emma Macdonald, Margaret Cassidy, Sijung Yun, Matthew R. Sapio, Pradipta Ray, Megan Doty, Pranavi Nara, Michael D. Burton, Stephanie Shiers, Abhik Ray-Chaudhury, Andrew J. Mannes, Theodore J. Price, Michael J. Iadarola, Ashok B. Kulkarni
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Pathological sensations caused by peripheral painful neuropathy occurring in Type 2 diabetes mellitus (T2DM) are often described as ‘sharp’ and ‘burning’ and are commonly spontaneous in origin. Proposed etiologies implicate dysfuncti
Externí odkaz:
https://doaj.org/article/0d188d635e2f4e2ca25b40fc967a2211
Autor:
Wenting Ma, Matthew R. Sapio, Allison P. Manalo, Dragan Maric, Mary Kate Dougherty, Taichi Goto, Andrew J. Mannes, Michael J. Iadarola
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Primary afferent neurons of the dorsal root ganglia (DRG) transduce peripheral nociceptive signals and transmit them to the spinal cord. These neurons also mediate analgesic control of the nociceptive inputs, particularly through the μ-opioid recept
Externí odkaz:
https://doaj.org/article/cb051981139d4e7db72d424669f69066
Autor:
Jenny J. Kim, Matthew R. Sapio, Fernando A. Vazquez, Dragan Maric, Amelia J. Loydpierson, Wenting Ma, Carlos A. Zarate, Michael J. Iadarola, Andrew J. Mannes
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Ketamine, an N-methyl-D-aspartate (NMDA)-receptor antagonist, is a recently revitalized treatment for pain and depression, yet its actions at the molecular level remain incompletely defined. In this molecular-pharmacological investigation in the rat,
Externí odkaz:
https://doaj.org/article/57f384f2492249be93330fb939f16c43
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
One of the biggest challenges for analgesic drug development is how to decide if a potential analgesic candidate will work in humans. What preclinical data are the most convincing, incentivizing and most predictive of success? Such a predicament is n
Externí odkaz:
https://doaj.org/article/f133d0c8396a4eaea72dbdaf7ead34e4
Autor:
Matthew R. Sapio, Fernando A. Vazquez, Amelia J. Loydpierson, Dragan Maric, Jenny J. Kim, Danielle M. LaPaglia, Henry L. Puhl, Van B. Lu, Stephen R. Ikeda, Andrew J. Mannes, Michael J. Iadarola
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Interoceptive and exteroceptive signals, and the corresponding coordinated control of internal organs and sensory functions, including pain, are received and orchestrated by multiple neurons within the peripheral, central and autonomic nervous system
Externí odkaz:
https://doaj.org/article/7ed59b6aa33a43f1a77e2329f43c8b57
Publikováno v:
The Journal of Pain. 23:1646-1650
The strong need for a new foundational molecular framework for human nervous system research at the nociceptive level is now matched by comprehensive and quantitative capabilities for analyzing nociceptive tissues such as pathologic peripheral tissue
Autor:
P Ellen Grant, Onassis A Caneris, Ramon G Gonzalez, Michael J Iadarola, Matthew R Sapio, Andrew J Mannes, David Borsook
Publikováno v:
Pain Medicine.
Autor:
Ellen S. Staedtler, Michael J. Iadarola, Matthew R. Sapio, Dragan Maric, André Ghetti, Andrew J. Mannes
Publikováno v:
The Journal of Pain. 24:15-16
Autor:
William F. Pritchard, John W. Karanian, Chris Jung, Ivane Bakhutashvili, Sheridan L. Reed, Matthew F. Starost, Brian R. Froelke, Teresa R. Barnes, Duncan Stevenson, Artemio Mendoza, David J. Eckstein, Bradford J. Wood, Brian K. Walsh, Andrew J. Mannes
Publikováno v:
Sci Transl Med
The COVID-19 pandemic demonstrated the need for inexpensive, easy-to-use, rapidly mass-produced resuscitation devices that could be quickly distributed in areas of critical need. In-line miniature ventilators based on principles of fluidics ventilate
Autor:
Andrew J. Mannes, Dragan Maric, Jeffrey Robinson, Matthew R. Sapio, Michael J. Iadarola, Taichi Goto, Leorey N. Saligan
Publikováno v:
J Pain
Pain is a common but potentially debilitating symptom, often requiring complex management strategies. To understand the molecular dynamics of peripheral inflammation and nociceptive pain, we investigated longitudinal changes in behavior, tissue struc