Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrew J. Macadam"'
Autor:
Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Cryo-EM structures reveal the role of glutathione (GSH) in poliovirus (PV) serotype 3 virus-like particle (VLP) stability, suggesting GSH or an analogous tight-binding antiviral offers potential for stabilizing VLP vaccines against PV.
Externí odkaz:
https://doaj.org/article/0d5db9da35ca49d08e79312c5f1dc633
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mona Shegdar, Helen Fox, Andrew J. Macadam, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Enterovirus A71 (EVA71) is a medically important virus that is commonly associated with hand, foot, and mouth disease (HFMD). It is responsible for periodic outbreaks, resulting in significant economic impact and loss of life. Vaccination of
Externí odkaz:
https://doaj.org/article/2ef97b3af6e44c7293cd043c6395f5a8
Autor:
Mohammad W. Bahar, Claudine Porta, Helen Fox, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Global vaccination programs using live-attenuated oral and inactivated polio vaccine (OPV and IPV) have almost eradicated poliovirus (PV) but these vaccines or their production pose significant risk in a polio-free world. Recombinant PV viru
Externí odkaz:
https://doaj.org/article/6d14a9581b7346d2a0e7c0c7fcf06ddd
Autor:
Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/747ed033b5d14c2baff8e310a56a1ac0
Autor:
Fadi G. Alnaji, Kirsten Bentley, Ashley Pearson, Andrew Woodman, Jonathan Moore, Helen Fox, Andrew J. Macadam, David J. Evans
Publikováno v:
Viruses, Vol 14, Iss 5, p 916 (2022)
Genetic recombination in RNA viruses is an important evolutionary mechanism. It contributes to population diversity, host/tissue adaptation, and compromises vaccine efficacy. Both the molecular mechanism and initial products of recombination are rela
Externí odkaz:
https://doaj.org/article/dcbf46d13af245678448a7d5fbacdc79
Autor:
Johanna Marsian, Helen Fox, Mohammad W. Bahar, Abhay Kotecha, Elizabeth E. Fry, David I. Stuart, Andrew J. Macadam, David J. Rowlands, George P. Lomonossoff
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Despite the success of current vaccination against poliomyelitis, safe, cheap and effective vaccines remain sought for continuing eradication effort. Here the authors use plants to express stabilized virus-like particles of type 3 poliovirus that can
Externí odkaz:
https://doaj.org/article/48bce09b6ee24f948fdf9a32e9d5ba0a
Autor:
Natalie J Kingston, Joseph S Snowden, Agnieszka Martyna, Mona Shegdar, Keith Grehan, Alison Tedcastle, Elaine Pegg, Helen Fox, Andrew J Macadam, Javier Martin, James M Hogle, David J Rowlands, Nicola J Stonehouse
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral lifecycle. While initially anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6b0829e1b634e1f8b5dad2afac80f5
https://doi.org/10.1101/2023.01.30.526315
https://doi.org/10.1101/2023.01.30.526315
Autor:
Ananda S Bandyopadhyay, Rahnuma Wahid, Ralf Clemens, Sue Ann Costa-Clemens, Andrew J. Macadam, Chris Gast, John Konz, John F. Modlin, Hilde Revets, Leen Suykens, Philippe De Smedt, Pierre Van Damme, Cara C. Burns, Ilse De Coster, Jennifer L. Konopka-Anstadt, William C. Weldon, M. Steven Oberste, Amy J Weiner, Kanchanamala Withanage, Olen M. Kew, Raul Andino
Publikováno v:
Lancet (London, England), vol 394, iss 10193
The lancet : international edition
Lancet (London, England)
The lancet : international edition
Lancet (London, England)
Background Use of oral live-attenuated polio vaccines (OPV), and injected inactivated polio vaccines (IPV) has almost achieved global eradication of wild polio viruses. To address the goals of achieving and maintaining global eradication and minimisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2827e5fe8d2377b34d7a8f05eb609c
https://doi.org/10.1016/s0140-6736(19)31279-6
https://doi.org/10.1016/s0140-6736(19)31279-6
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Global vaccination programs using live-attenuated oral and inactivated polio vaccine (OPV and IPV) have almost eradicated poliovirus (PV) but these vaccines or their production pose significant risk in a polio-free world. Recombinant PV virus-like pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f46606e89b10ec43aca1e3a5e4e36f
http://europepmc.org/articles/PMC7794334
http://europepmc.org/articles/PMC7794334
Autor:
Philip D. Minor, Thomas R. Kreil, Philip O. Rabel, Jens Modrof, Helen Fox, Andrew J. Macadam, Maria R. Farcet, Andreas Schirmer
Publikováno v:
Transfusion. 58
Background Wild-type poliovirus may be eradicated soon and under WHO GAPIII guidance, laboratory use will be discontinued or subject to strict containment. Per US Code of Federal Regulations, however, immunoglobulin lot release testing will still req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3914e62a3941f41987624b71efe5ad1b
https://pubmed.ncbi.nlm.nih.gov/30536436
https://pubmed.ncbi.nlm.nih.gov/30536436