Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andrew J. Lutkewitte"'
Autor:
Roshan Kumari, Michael E. Ponte, Edziu Franczak, John C. Prom, Maura F. O'Neil, Mihaela E. Sardiu, Andrew J. Lutkewitte, Lane K. Christenson, Kartik Shankar, E. Matthew Morris, John P. Thyfault
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101908- (2024)
Objective: Menopause adversely impacts systemic energy metabolism and increases the risk of metabolic disease(s) including hepatic steatosis, but the mechanisms are largely unknown. Dosing female mice with vinyl cyclohexene dioxide (VCD) selectively
Externí odkaz:
https://doaj.org/article/f1c9790f1b4f4ccb9bfa9df70f140226
Autor:
Nicole K.H. Yiew, Stanislaw Deja, Daniel Ferguson, Kevin Cho, Chaowapong Jarasvaraparn, Miriam Jacome-Sosa, Andrew J. Lutkewitte, Sandip Mukherjee, Xiaorong Fu, Jason M. Singer, Gary J. Patti, Shawn C. Burgess, Brian N. Finck
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108196- (2023)
Summary: The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via de novo lipogenesis (DNL) when carbohydrates are abundant. Mitochondria
Externí odkaz:
https://doaj.org/article/802c3f379cbe48bdb9a10949ed2a6500
Autor:
Sandip Mukherjee, Molee Chakraborty, Eliwaza N. Msengi, Jake Haubner, Jinsong Zhang, Matthew J. Jellinek, Haley L. Carlson, Kelly Pyles, Barbara Ulmasov, Andrew J. Lutkewitte, Danielle Carpenter, Kyle S. McCommis, David A. Ford, Brian N. Finck, Brent A. Neuschwander-Tetri, Anutosh Chakraborty
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101767- (2023)
Objective: Defining the regulators of cell metabolism and signaling is essential to design new therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases control diverse cellular functions by ubiquitination-mediated regulation of protein
Externí odkaz:
https://doaj.org/article/b2642d46704a4c24822cb884661aab61
Autor:
Daniel Ferguson, Sophie J. Eichler, Nicole K.H. Yiew, Jerry R. Colca, Kevin Cho, Gary J. Patti, Trevor M. Shew, Andrew J. Lutkewitte, Sandip Mukherjee, Kyle S. McCommis, Natalie M. Niemi, Brian N. Finck
Publikováno v:
Molecular Metabolism, Vol 70, Iss , Pp 101694- (2023)
Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis (NASH). We evaluated whether MPC inhibitors (MPCi) might correct impairments in
Externí odkaz:
https://doaj.org/article/3898d186981f4a0e95dd6457eab4e374
Publikováno v:
Metabolites, Vol 13, Iss 5, p 627 (2023)
A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely
Externí odkaz:
https://doaj.org/article/f8296e7a1fbe4245ac0ee2dd816a90b4
Autor:
Andrew J. Lutkewitte, Jason M. Singer, Trevor M. Shew, Michael R. Martino, Angela M. Hall, Mai He, Brian N. Finck
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101204- (2021)
Objective: Monoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT activity in the development of obesity-related hepatic insulin resistance. I
Externí odkaz:
https://doaj.org/article/b66bdbed09e74f13887f9d1d762b91e7
Autor:
Andrew J. Lutkewitte, Kyle S. McCommis, George G. Schweitzer, Kari T. Chambers, Mark J. Graham, Lingjue Wang, Gary J. Patti, Angela M. Hall, Brian N. Finck
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 528-538 (2019)
During prolonged fasting, the liver plays a central role in maintaining systemic energy homeostasis by producing glucose and ketones in processes fueled by oxidation of fatty acids liberated from adipose tissue. In mice, this is accompanied by transi
Externí odkaz:
https://doaj.org/article/182766521768470a976245b2e220742c
Autor:
Kim H.H. Liss, Andrew J. Lutkewitte, Terri Pietka, Brian N. Finck, Michael Franczyk, Jun Yoshino, Samuel Klein, Angela M. Hall
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1630-1639 (2018)
Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT)
Externí odkaz:
https://doaj.org/article/301bda972ee148a583d9c61af85dbb7c
Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity
Autor:
Andrew J. Lutkewitte, Brian N. Finck
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1386 (2020)
Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway that has incredibly important structural functions as a component of cell membranes and dynamic effects on intracellular and intercellular signaling pa
Externí odkaz:
https://doaj.org/article/96992a76db9c434b97535df5adc6cc6c
Autor:
Jason M. Singer, Trevor M. Shew, Daniel Ferguson, M. Katie Renkemeyer, Terri A. Pietka, Angela M. Hall, Brian N. Finck, Andrew J. Lutkewitte
Publikováno v:
Obesity. 30:2122-2133
Monoacylglycerol O-acyltransferase 1 (Mogat1), a lipogenic enzyme that converts monoacylglycerol to diacylglycerol, is highly expressed in adipocytes and may regulate lipolysis by re-esterifying fatty acids released during times when lipolytic rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f5e4ceccbd0330db0cb319d7ff5331
https://doi.org/10.1002/oby.23538
https://doi.org/10.1002/oby.23538