Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Andrew J. Locke"'
Autor:
Ajit K. Sharma, Amira Mohammed Fitieh, Andrew J. Locke, Jana Yasser Hafez Ali, Ismail Hassan Ismail
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101917- (2023)
Summary: Here, we present a chromatin-immunoprecipitation-based protocol to quantify the recruitment of proteins adjacent to site-specific DNA double-strand breaks (DSBs), such as proteins involved in DSB repair. We describe steps to induce DSBs in U
Externí odkaz:
https://doaj.org/article/b7ab18c768fd4966b7d86e69e1696ec8
Autor:
Amira Fitieh, Andrew J. Locke, Fatemeh Mashayekhi, Fajr Khaliqdina, Ajit K. Sharma, Ismail Hassan Ismail
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110536- (2022)
Summary: BMI-1 is an essential regulator of transcriptional silencing during development. Recently, the role of BMI-1 in the DNA damage response has gained much attention, but the exact mechanism of how BMI-1 participates in the process is unclear. H
Externí odkaz:
https://doaj.org/article/bfa0a99391084cc19bce9ba32c9c7bdc
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2976 (2021)
The polycomb group (PcG) proteins are a class of transcriptional repressors that mediate gene silencing through histone post-translational modifications. They are involved in the maintenance of stem cell self-renewal and proliferation, processes that
Externí odkaz:
https://doaj.org/article/08b653428a1244789795df7e00f5030d
Autor:
Ajit K. Sharma, Amira Mohammed Fitieh, Andrew J. Locke, Jana Yasser Hafez Ali, Ismail Hassan Ismail
Publikováno v:
STAR protocols. 4(1)
Here, we present a chromatin-immunoprecipitation-based protocol to quantify the recruitment of proteins adjacent to site-specific DNA double-strand breaks (DSBs), such as proteins involved in DSB repair. We describe steps to induce DSBs in U2OS osteo
Autor:
Jean-Yves Masson, Daryl A. Ronato, Tanzeem Ahmed Rafique, Amira Fitieh, Ismail Hassan Ismail, Mobina Motamedi, Fatemeh Mashayekhi, Lazina Hossain, Andrew J Locke, Glynnis McCrostie
Publikováno v:
Nucleic Acids Research
Double-strand breaks and stalled replication forks are a significant threat to genomic stability that can lead to chromosomal rearrangements or cell death. The protein CtIP promotes DNA end resection, an early step in homologous recombination repair,
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2976, p 2976 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 2976, p 2976 (2021)
The polycomb group (PcG) proteins are a class of transcriptional repressors that mediate gene silencing through histone post-translational modifications. They are involved in the maintenance of stem cell self-renewal and proliferation, processes that
Publikováno v:
Journal of Organometallic Chemistry. :669-676
The synthesis of [4]ferrocenophanes containing a ( Z )-1,4-but-2-endiyl bridge is described. Starting from either achiral (R=H), meso (R=Me, Ph) or scalemic (R=Me, 4-MeOC 6 H 4 ) 1,1′-di{CHR(OAc)}ferrocenes, vinylation with a mixture of vinyl magne
Publikováno v:
Organometallics. 18:3750-3759
(R)-α-Ferrocenyl alcohols underwent conversion to their corresponding methyl ethers on treatment with MeOH/AcOH, which were in turn converted to ethyl 3-ferrocenylpropanoates when combined with 1-ethoxy-1-(trimethylsilyloxy)ethene and BF3·OEt2. Aft
Publikováno v:
Tetrahedron: Asymmetry. 9:2377-2407
Publikováno v:
Tetrahedron: Asymmetry. 8:3383-3386
(R,R)-1,1′-Bis(2-chloroformyl-1-phenylethyl)ferrocene undergoes SnCl4 promoted intramolecular Friedel-Crafts cyclisation to give a 1.5:1 ratio of singly bridged ferrocenophane isomers. After separation of their corresponding methyl esters, the majo