Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Andrew J. Kocab"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-9 (2024)
Abstract Due to the large number of genes and mutations that result in inherited retinal degenerations (IRD), there has been a paucity of therapeutic options for these patients. There is a large unmet need for therapeutic approaches targeting shared
Externí odkaz:
https://doaj.org/article/bfe6b0e9b11b494ead3b40ac372e4949
Autor:
Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas s
Externí odkaz:
https://doaj.org/article/414b24d38f60448292315ecd971e04c6
Autor:
David N. Zacks, Andrew J. Kocab, Joanne J. Choi, Meredith S. Gregory-Ksander, Marisol Cano, James T. Handa
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 592, p 592 (2022)
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world. While great advances have been made in the treatment of the neovascular (“wet”) form of the disease, there is still a significant need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313f5b4f658d3109b4f06fb21fa1fd8a
https://www.mdpi.com/2077-0383/11/3/592
https://www.mdpi.com/2077-0383/11/3/592
Autor:
Andrew J. Kocab, Colin S. Duckett
Publikováno v:
FEBS Journal. 283:221-231
The inhibitor of apoptosis (IAP) proteins have often been considered inhibitors of cell death due to early studies describing their ability to directly bind and inhibit caspases, the primary factors that implement apoptosis. However, a greater unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ba134b02f6604cf49f10985f55d613
https://doi.org/10.1111/febs.13554
https://doi.org/10.1111/febs.13554
Publikováno v:
Oncogene
Cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2) play central roles in signal transduction mediated by numerous receptors that participate in inflammatory and immune responses. In certain pathways, such as activation of NF-κB, their degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca94a07ae7c53f97874e4f7598eb1c0
https://pubmed.ncbi.nlm.nih.gov/25659587
https://pubmed.ncbi.nlm.nih.gov/25659587
Publikováno v:
Cell cycle (Georgetown, Tex.). 13(6)
Copper is an essential trace element that plays key roles in many metabolic processes. Homeostatic regulation of intracellular copper is normally tightly controlled, but deregulated copper levels are found in numerous metabolic and neurodegenerative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e309561c405978f5ca3f7fc710e277
https://pubmed.ncbi.nlm.nih.gov/24552822
https://pubmed.ncbi.nlm.nih.gov/24552822
Autor:
Scott D. Larsen, Susan M. Wade, Andrew J. Kocab, Nicole L. Harzdorf, Jessica L. Bell, H. D. Hollis Showalter, Richard R. Neubig, Jenny G. Ryu, Chris R. Evelyn
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
We recently identified bis(amide) CCG-1423 (1) as a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. An initial structure-activity relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc65a75752998e5e72cee3ae1d44483
https://pubmed.ncbi.nlm.nih.gov/19963382
https://pubmed.ncbi.nlm.nih.gov/19963382