Výsledky vyhledávání - "Andrew J. Janeczek"

Synthesis of 'neoprofen', a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

Autor: Gregory B. Dudley, Suresh Eyunni, Ron R. Ramsubhag, Elizabeth Mazzio, Christina M. Dadich, Andrew J. Janeczek, Chelsea Massaro, Tung T. Hoang, Karam F.A. Soliman

Publikováno v: Organic & Biomolecular Chemistry. 14:7855-7858

3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9554651b54008f6273812e433791e1e
https://doi.org/10.1039/c6ob01351a

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