Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Andrew J. Highton"'
Autor:
Andrew J. Highton, Björn-Philipp Diercks, Franziska Möckl, Gloria Martrus, Jürgen Sauter, Alexander H. Schmidt, Madeleine J. Bunders, Christian Körner, Andreas H. Guse, Marcus Altfeld
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells demonstrate heterogeneous expression of inhibitory surface receptors. Signaling through these vario
Externí odkaz:
https://doaj.org/article/097851678ac4475a90956c3cbdae10aa
Autor:
Andrew J. Highton, Madeleine E. Zinser, Lian Ni Lee, Claire L. Hutchings, Catherine De Lara, Chansavath Phetsouphanh, Chris B. Willberg, Claire L. Gordon, Paul Klenerman, Emanuele Marchi
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Persistent viruses such as murine cytomegalovirus (MCMV) and adenovirus-based vaccines induce strong, sustained CD8+ T-cell responses, described as memory “inflation”. These retain functionality, home to peripheral organs and are asso
Externí odkaz:
https://doaj.org/article/bec4a62e35804da0864da57582d498ea
Autor:
Caroline Pfeifer, Andrew J. Highton, Sven Peine, Jürgen Sauter, Alexander H. Schmidt, Madeleine J. Bunders, Marcus Altfeld, Christian Körner
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
NK cells expressing self-inhibitory receptors display increased functionality compared to NK cells lacking those receptors. The acquisition of functional competence in these particular NK-cell subsets is termed education. Little is known about the un
Externí odkaz:
https://doaj.org/article/e4604743ca0f43dea501f42b284eca20
Autor:
Samuel E Norton, Tiffany Khong, Malarmathy Ramachandran, Andrew J Highton, Kirsten A Ward‐Hartstonge, Jake Shortt, Andrew Spencer, Roslyn A Kemp
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Objectives Lenalidomide (LEN) is used to treat multiple myeloma (MM) and shows in vitro synergy with KappaMab (KM), a chimeric antibody specific for Kappa Myeloma antigen, an antigen exclusively expressed on the surface of kappa‐restricted
Externí odkaz:
https://doaj.org/article/3c64e8fff2fb416e86b78486d31102b4
Autor:
Hamish CK Angus, Paulo CM Urbano, Gemma A Laws, Shijun Fan, Safina Gadeock, Michael Schultz, Grant Butt, Andrew J Highton, Roslyn A Kemp
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 8, Pp n/a-n/a (2022)
Abstract Objectives Crohn's disease (CD) initiation and pathogenesis are believed to involve an environmental trigger in a genetically susceptible person that results in an immune response against commensal gut bacteria, leading to a compromised inte
Externí odkaz:
https://doaj.org/article/50612b2adcad499cb4b121421df98e85
Autor:
Lian N Lee, Beatrice Bolinger, Zoltan Banki, Catherine de Lara, Andrew J Highton, Julia M Colston, Claire Hutchings, Paul Klenerman
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006782 (2017)
The efficacies of many new T cell vaccines rely on generating large populations of long-lived pathogen-specific effector memory CD8 T cells. However, it is now increasingly recognized that prior infection history impacts on the host immune response.
Externí odkaz:
https://doaj.org/article/626b9d0344c24ca4baf49288d6449eb8
Autor:
Jan P. Bremer, Martin E. Baumdick, Marius S. Knorr, Lucy H.M. Wegner, Jasmin Wesche, Ana Jordan-Paiz, Johannes M. Jung, Andrew J. Highton, Julia Jäger, Ole Hinrichs, Sebastien Brias, Jennifer Niersch, Luisa Müller, Renée R.C.E. Schreurs, Tobias Koyro, Sebastian Löbl, Leonore Mensching, Leonie Konczalla, Annika Niehrs, Florian W. R. Vondran, Christoph Schramm, Angelique Hölzemer, Karl Oldhafer, Ingo Königs, Stefan Kluge, Daniel Perez, Konrad Reinshagen, Steven T. Pals, Nicola Gagliani, Sander P. Joosten, Maya Topf, Marcus Altfeld, Madeleine J. Bunders
Organoids have emerged as a powerful technology to investigate human development, model diseases and for drug discovery. However, analysis tools to rapidly and reproducibly quantify organoid parameters from microscopy images are lacking. We developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13521250821e90d01118ad2f34ec3450
https://doi.org/10.1101/2022.09.06.506648
https://doi.org/10.1101/2022.09.06.506648
Autor:
Christian Perez-Shibayama, Claire Hutchings, Paul Klenerman, Senthil Chinnakannan, Julia M Colston, Burkhard Ludewig, Andrew J Highton
Publikováno v:
European Journal of Immunology
Adenoviral vectors induce robust epitope-specific CD8+ T cell responses. Within the repertoire of responses generated both conventional memory evolution and the phenomenon of memory inflation are seen. The rules governing which epitopes inflate are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b537b256c20eec817470b5c6c5a6ec
https://doi.org/10.1002/eji.201948143
https://doi.org/10.1002/eji.201948143
Autor:
C Willberg, C de Lara, Madeleine Zinser, Chansavath Phetsouphanh, Claire Hutchings, Emanuele Marchi, Andrew J Highton, Lian Ni Lee, Paul Klenerman, Claire L. Gordon
Publikováno v:
Wellcome Open Research
Background: Persistent viruses such as murine cytomegalovirus (MCMV) and adenovirus-based vaccines induce strong, sustained CD8+ T-cell responses, described as memory “inflation”. These retain functionality, home to peripheral organs and are asso
Autor:
Claire Hutchings, Andrew J Highton, Julia M Colston, Paul Klenerman, Christian Perez-Shibayama, Burkhard Ludewig, Senthil Chinnakannan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe687fd78fae200d1eb6f9d2f9a65b57
https://doi.org/10.1002/eji.201948143/v2/response1
https://doi.org/10.1002/eji.201948143/v2/response1