Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Andrew J. Halayko"'
Autor:
Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Andrew J. Halayko, Christopher D. Pascoe, Meaghan J. Jones
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTSmoking is a potent cause of asthma exacerbations, chronic obstructive pulmonary disease (COPD) and many other health defects, and changes in DNA methylation (DNAm) have been identified as a potential link between smoking and these health out
Externí odkaz:
https://doaj.org/article/43f8a707b578469baa2af0d1c31ed132
Autor:
Jignesh Vaghasiya, Aruni Jha, Sujata Basu, Alaina Bagan, Siwon K. Jengsuksavat, Amir Ravandi, Christopher D. Pascoe, Andrew J. Halayko
Publikováno v:
Biology, Vol 13, Iss 8, p 627 (2024)
Oxidative stress is associated with asthma pathobiology. We reported that oxidized phosphatidylcholines (OxPCs) are mediators of oxidative stress and accumulate in the lung in response to allergen challenge. The current study begins to unravel mechan
Externí odkaz:
https://doaj.org/article/026b672d2edd4b98a07e6a0b92ca4df0
Autor:
Dina H. D. Mostafa, Mahadevappa Hemshekhar, Hadeesha Piyadasa, Anthony Altieri, Andrew J. Halayko, Christopher D. Pascoe, Neeloffer Mookherjee
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Biological sex impacts disease prevalence, severity and response to therapy in asthma, however preclinical studies often use only one sex in murine models. Here, we detail sex-related differences in immune responses using a house dust mite (
Externí odkaz:
https://doaj.org/article/6fbde9b5718e4a2594419abc7621e585
Autor:
Jay Kormish, Tejas Ghuman, Richard Y. Liu, Sadeesh K. Srinathan, Lawrence Tan, Kristen Graham, Stephanie Enns, Gordon Buduhan, Andrew J. Halayko, Christopher D. Pascoe, Biniam Kidane
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10051 (2023)
Thoracic surgeries involving resection of lung tissue pose a risk of severe postoperative pulmonary complications, including acute respiratory distress syndrome (ARDS) and respiratory failure. Lung resections require one-lung ventilation (OLV) and, t
Externí odkaz:
https://doaj.org/article/b008bf2a7cc34a8c86823508ca84a92a
Autor:
Tao Chen, Amy Po Yu Tsai, Seo Am Hur, Alyson W. Wong, Mohsen Sadatsafavi, Jolene H. Fisher, Kerri A. Johannson, Deborah Assayag, Julie Morisset, Shane Shapera, Nasreen Khalil, Charlene D. Fell, Helene Manganas, Gerard Cox, Teresa To, Andrea S. Gershon, Nathan Hambly, Andrew J. Halayko, Pearce G. Wilcox, Martin Kolb, Christopher J. Ryerson
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Rationale The University of California, San Diego Shortness of Breath Questionnaire (UCSDSOBQ) is a frequently used domain-specific dyspnea questionnaire; however, there is little information available regarding its use and minimum important
Externí odkaz:
https://doaj.org/article/02be01e682484773ab03379e97c4b7ef
Autor:
Mahadevappa Hemshekhar, Dina H. D. Mostafa, Victor Spicer, Hadeesha Piyadasa, Danay Maestre-Batlle, Anette K. Bolling, Andrew J. Halayko, Christopher Carlsten, Neeloffer Mookherjee
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Biological sex influences disease severity, prevalence and response to therapy in allergic asthma. However, allergen-mediated sex-specific changes in lung protein biomarkers remain undefined. Here, we report sex-related differences in specific protei
Externí odkaz:
https://doaj.org/article/0eca234540c940da8bfad46483f4d910
Autor:
Thomas H. Mahood, Christopher D. Pascoe, Tobias K. Karakach, Aruni Jha, Sujata Basu, Peyman Ezzati, Victor Spicer, Neeloffer Mookherjee, Andrew J. Halayko
Publikováno v:
ACS Omega, Vol 6, Iss 2, Pp 1171-1189 (2021)
Externí odkaz:
https://doaj.org/article/74375d0e46a440cb93c0276699ab6f97
Autor:
Alyson W. Wong, Tae Yoon Lee, Kerri A. Johannson, Deborah Assayag, Julie Morisset, Charlene D. Fell, Jolene H. Fisher, Shane Shapera, Andrea S. Gershon, Gerard Cox, Andrew J. Halayko, Nathan Hambly, Helene Manganas, Mohsen Sadatsafavi, Pearce G. Wilcox, Teresa To, Veronica Marcoux, Nasreen Khalil, Martin Kolb, Christopher J. Ryerson
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Comorbidities are frequent and have been associated with poor quality of life, increased hospitalizations, and mortality in patients with interstitial lung disease (ILD). However, it is unclear how comorbidities lead to these nega
Externí odkaz:
https://doaj.org/article/20adba84a4ee4ef69531905b9f1bdd30
Autor:
Mahadevappa Hemshekhar, Hadeesha Piyadasa, Dina Mostafa, Leola N. Y. Chow, Andrew J. Halayko, Neeloffer Mookherjee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cationic host defense peptides (CHDP) are immunomodulatory molecules that control infections and contribute to immune homeostasis. CHDP such as cathelicidin and calprotectin expression is altered in the arthritic synovium, and in the lungs of asthma
Externí odkaz:
https://doaj.org/article/80e3c1e1609d4ccea9a2da3dce04f76f
Autor:
Hoeke A. Baarsma, Bing Han, Wilfred J. Poppinga, Saskia Driessen, Carolina R. S. Elzinga, Andrew J. Halayko, Herman Meurs, Harm Maarsingh, Martina Schmidt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruc
Externí odkaz:
https://doaj.org/article/2689a820502b4991a3bb1673a2f9baab