Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrew J. Grottick"'
Autor:
Lawrence Ma, Brittney Russell, Scott Hobson, Christina Wong, Andrew J Grottick, Tristan J Hynes, Michael M. Barrus, Melanie Tremblay, Catharine A. Winstanley, Kelly M. Hrelja
Publikováno v:
Behavioral Neuroscience. 135:8-23
Dopamine D2/3 receptor agonists are less likely to trigger dyskinesias than L-dopa while still offering relief from the motor symptoms of Parkinson's disease (PD). However, these drugs can cause serious impulse control problems and gambling disorders
Autor:
Samuel A. Barnes, Andrew J. Grottick, David L MacQueen, Jared W. Young, Erin K. Sanabria, Chris Carroll, Vishal Bobba
Publikováno v:
Psychopharmacology. 238:979-990
Cognitive function is closely linked to functional outcomes in psychiatric disorders such as schizophrenia, however developing effective treatments for cognitive dysfunction have proven elusive. Potential reasons for this may include the complexity o
Autor:
Thomas O, Schrader, Xiuwen, Zhu, Michelle, Kasem, Albert, Ren, Chunyan, Liu, Chunrui, Wu, Huong, Dang, Minh, Le, Joel, Gatlin, Kelli, Chase, John, Frazer, Kevin T, Whelan, Andrew J, Grottick, Clayton, Hutton, Jeremy, Barden, Chuan, Chen, Alvaro, Ortiz, Konrad, Feichtinger, Graeme, Semple
Publikováno v:
Bioorganicmedicinal chemistry letters. 38
A series of novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines were identified as potent and selective agonists of the 5-HT
Autor:
Albert, Ren, Xiuwen, Zhu, Konrad, Feichtinger, Juerg, Lehman, Michelle, Kasem, Thomas O, Schrader, Amy, Wong, Huong, Dang, Minh, Le, John, Frazer, David J, Unett, Andrew J, Grottick, Kevin T, Whelan, Michael E, Morgan, Carleton R, Sage, Graeme, Semple
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(5)
A series of potential new 5-HT
Autor:
Michelle Solomon, Lars Thoresen, Robert M. Jones, Andrew J. Grottick, David J. Unett, Abu J.M. Sadeque, Chuan Chen, Ibragim Gaidarov, Hussien A. Al-Shamma, Jayant Thatte, Graeme Semple, Jae-Kyu Jung, Amin Usmani, Jeremy Barden, Xiuwen Zhu, Woo Hyun Yoon, Sangdon Han, Christopher Ronald J
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1309-1313
The discovery of a novel, selective and fully efficacious CB2 agonist with satisfactory pharmacokinetic and pharmaceutical properties is described. Compound 6 was efficacious in a rat model of osteoarthritis pain following oral administration and, in
Autor:
Clayton Hutton, Andrew J. Grottick, Graeme Semple, Konrad Feichtinger, Thomas O. Schrader, Jeremy Barden, Chunyan Liu, Kevin Whelan, Xiuwen Zhu, Chuan Chen, Chunrui Wu, John Frazer, Huong T. Dang, Joel Gatlin, Alvaro Ortiz, Minh Le, Albert S. Ren, Michelle Kasem, Kelli Chase
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 38:127872
A series of novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines were identified as potent and selective agonists of the 5-HT2C receptor. Optimizations performed on a previously reported series of racemic tetrahydroquinoline-based
Autor:
Minh Le, Albert S. Ren, Andrew J. Grottick, Graeme Semple, Kevin Whelan, Kelli Chase, Carleton R. Sage, Bilal Al Doori, Jenny Dong, Michelle Kasem, Chunrui Wu, Konrad Feichtinger, Jing Wei, Thomas O. Schrader, Huong T. Dang, Joel Gatlin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5877-5882
The syntheses, structure-activity relationships (SARs), and biological activities of tetrahydroquinoline-based tricyclic amines as 5-HT2C receptor agonists are reported. An early lead containing a highly unique 6,6,7-ring system was optimized for bot
Autor:
Albert S. Ren, Kevin Whelan, Konrad Feichtinger, Xiuwen Zhu, Michael Morgan, David J. Unett, Graeme Semple, Andrew J. Grottick, Amy Siu-Ting Wong, Michelle Kasem, Huong T. Dang, Juerg Lehman, Minh Le, Thomas O. Schrader, John Frazer, Carleton R. Sage
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126929
A series of potential new 5-HT2 receptor scaffolds based on a simplification of the clinically studied, 5-HT2CR agonist vabicaserin, were designed. An in vivo feeding assay early in our screening process played an instrumental part in the lead identi
Autor:
Dominic P. Behan, Kevin Whelan, Michael Morgan, Erin K. Sanabria, Andrew J. Grottick, Carleton R. Sage
Publikováno v:
Psychopharmacology
Rationale Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenflu
Autor:
Thomas O, Schrader, Michelle, Kasem, Albert, Ren, Konrad, Feichtinger, Bilal, Al Doori, Jing, Wei, Chunrui, Wu, Huong, Dang, Minh, Le, Joel, Gatlin, Kelli, Chase, Jenny, Dong, Kevin T, Whelan, Carleton, Sage, Andrew J, Grottick, Graeme, Semple
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(24)
The syntheses, structure-activity relationships (SARs), and biological activities of tetrahydroquinoline-based tricyclic amines as 5-HT