Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Andrew J. Griffith"'
Autor:
Deng Chen, Chunlong Zhao, Jianqiu Zhang, Catharina W. J. Knol, Angelina Osipyan, Nad'a Majerníková, Tingting Chen, Zhangping Xiao, Jeaunice Adriana, Andrew J. Griffith, Abel Soto Gamez, Petra E. van derWouden, Robert P. Coppes, Amalia M. Dolga, Hidde J. Haisma, Frank J. Dekker
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, DNA
Externí odkaz:
https://doaj.org/article/5f1b5535d1c64d3381cee0b2777a4e5b
Autor:
Dillon Strepay, Rafal T. Olszewski, Sydney Nixon, Soumya Korrapati, Samuel Adadey, Andrew J. Griffith, Yijun Su, Jiamin Liu, Harshad Vishwasrao, Shoujun Gu, Thomas Saunders, Isabelle Roux, Michael Hoa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The stria vascularis (SV) is a stratified epithelium in the lateral wall of the mammalian cochlea, responsible for both endolymphatic ion homeostasis and generation of the endocochlear potential (EP) critical for normal hearing. The SV has t
Externí odkaz:
https://doaj.org/article/bb8c7c0b6df341d3a917073f881c322a
Autor:
Kevin Isgrig, Yasuko Ishibashi, Hyun Jae Lee, Jianliang Zhu, Mhamed Grati, Jean Bennett, Andrew J. Griffith, Isabelle Roux, Wade W. Chien
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 371-383 (2022)
Inner ear gene therapy using adeno-associated viruses (AAVs) has been successfully applied to several mouse models of hereditary hearing loss to improve their auditory function. While most inner ear gene therapy studies have focused on the mechanosen
Externí odkaz:
https://doaj.org/article/18c81c1ca47f44779f4c8ee24b6f2199
Autor:
Janet R. Chao, Parna Chattaraj, Tina Munjal, Keiji Honda, Kelly A. King, Christopher K. Zalewski, Wade W. Chien, Carmen C. Brewer, Andrew J. Griffith
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-6 (2019)
Abstract Background Recessive mutations of coding regions and splice sites of the SLC26A4 gene cause hearing loss with enlargement of the vestibular aqueduct (EVA). Some patients also have a thyroid iodination defect that can lead to multinodular goi
Externí odkaz:
https://doaj.org/article/a1762e3b69644b61a4f412a1d20d7f56
Autor:
Hiroshi Nakanishi, Pragya Prakash, Taku Ito, H. Jeffrey Kim, Carmen C. Brewer, Danielle Harrow, Isabelle Roux, Seiji Hosokawa, Andrew J. Griffith
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Sensorineural hearing loss can result from dysfunction of the inner ear, auditory nerve, or auditory pathways in the central nervous system. Sensorineural hearing loss can be associated with age, exposure to ototoxic drugs or noise, or mutations in n
Externí odkaz:
https://doaj.org/article/cd1de9a555114b5cbf40476f1957f3a4
Autor:
Kiyoto Kurima, Seham Ebrahim, Bifeng Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshiyuki Kawashima, Byung Yoon Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar
Publikováno v:
Cell Reports, Vol 12, Iss 10, Pp 1606-1617 (2015)
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET
Externí odkaz:
https://doaj.org/article/956b6b945a184c899793d843c0c644ab
Autor:
Taku Ito, Xiangming Li, Kiyoto Kurima, Byung Yoon Choi, Philine Wangemann, Andrew J. Griffith
Publikováno v:
Neurobiology of Disease, Vol 66, Iss , Pp 53-65 (2014)
SLC26A4 mutations can cause a distinctive hearing loss phenotype with sudden drops and fluctuation in patients. Existing Slc26a4 mutant mouse lines have a profound loss of hearing and vestibular function, with severe inner ear malformations that do n
Externí odkaz:
https://doaj.org/article/b20cdf786ace4ee1a4a2cd4a39110611
Autor:
Saumil Sethna, Wadih M Zein, Sehar Riaz, Arnaud PJ Giese, Julie M Schultz, Todd Duncan, Robert B Hufnagel, Carmen C Brewer, Andrew J Griffith, T Michael Redmond, Saima Riazuddin, Thomas B Friedman, Zubair M Ahmed
Publikováno v:
eLife, Vol 10 (2021)
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of PCDH15 (USH1F) has an ~2% carrier frequency amongst Ashkenazi Jews accounts for
Externí odkaz:
https://doaj.org/article/b6069badb6b14498bff5ec71588e5683
Autor:
Rabia Faridi, Rizwan Yousaf, Shoujun Gu, Sayaka Inagaki, Amy E. Turriff, Keith Pelstring, Bin Guan, Amelia Naik, Andrew J. Griffith, Samuel Mawuli Adadey, Elvis Twumasi Aboagye, Gordon A. Awandare, Robert J. Morell, Ekaterini Tsilou, Amanda G. Noyes, Laura A. G. Sulmonte, Ambroise Wonkam, Isabelle Schrauwen, Suzanne M. Leal, Hela Azaiez, Carmen C. Brewer, Sheikh Riazuddin, Robert B. Hufnagel, Michael Hoa, Wadih M. Zein, J. Karl de Dios, Thomas B. Friedman
Publikováno v:
Clinical Genetics. 103:699-703
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fa28c57eb07bd63d0020e5fb71c72c4
https://doi.org/10.1111/cge.14312
https://doi.org/10.1111/cge.14312
Autor:
Andrew J. Griffith, Risa Tona, Liz M Nouel-Saied, Parna Chattaraj, Robert J. Morell, Thomas B. Friedman, Suzanne M. Leal, Rabia Faridi, Rizwan Yousaf, Anushree Acharya, Adebolajo A. Adeyemo, Thashi Bharadwaj, Samuel Okorie, Isabelle Roux, Isabelle Schrauwen
Publikováno v:
European Journal of Human Genetics
Although variant alleles of hundreds of genes are associated with sensorineural deafness in children, the genes and alleles involved remain largely unknown in the Sub-Saharan regions of Africa. We ascertained 56 small families mainly of Yoruba ethno-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0f5029ba3f885e1fe0b276d60c2e60
https://doi.org/10.1038/s41431-021-00984-w
https://doi.org/10.1038/s41431-021-00984-w