Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Andrew J. Gentles"'
Autor:
Kevin Brennan, Almudena Espín-Pérez, Serena Chang, Nikita Bedi, Saumyaa Saumyaa, June Ho Shin, Sylvia K. Plevritis, Olivier Gevaert, John B. Sunwoo, Andrew J. Gentles
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-26 (2023)
Abstract Background The prognosis for patients with head and neck cancer (HNC) is poor and has improved little in recent decades, partially due to lack of therapeutic options. To identify effective therapeutic targets, we sought to identify molecular
Externí odkaz:
https://doaj.org/article/64cfbc02ed7142e4ba40972bf22f174f
Autor:
Almudena Espín-Pérez, Kevin Brennan, Asiri Saumya Ediriwickrema, Olivier Gevaert, Izidore S. Lossos, Andrew J. Gentles
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-9 (2022)
Abstract Lack of accurate methods for early lymphoma detection limits the ability to cure patients. Since patients with Non-Hodgkin lymphomas (NHL) who present with advanced disease have worse outcomes, accurate and sensitive methods for early detect
Externí odkaz:
https://doaj.org/article/ca0ac65f02104d1ba4809fa7abf17715
Autor:
Brooks A. Benard, Logan B. Leak, Armon Azizi, Daniel Thomas, Andrew J. Gentles, Ravindra Majeti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Individual studies have been underpowered to draw clear associations between clonal heterogeneity and response to therapy in acute myeloid leukemia (AML). Here, the authors aggregate multiple AML cohorts and are able to correlate the clonal abundance
Externí odkaz:
https://doaj.org/article/a4b271e40ef04eaa869544eebbd2896e
Autor:
Andrew J. Gentles, Angela Bik-Yu Hui, Weiguo Feng, Armon Azizi, Ramesh V. Nair, Gina Bouchard, David A. Knowles, Alice Yu, Youngtae Jeong, Alborz Bejnood, Erna Forgó, Sushama Varma, Yue Xu, Amanda Kuong, Viswam S. Nair, Rob West, Matt van de Rijn, Chuong D. Hoang, Maximilian Diehn, Sylvia K. Plevritis
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Tumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and
Externí odkaz:
https://doaj.org/article/cc0f2098680f4d72b3ab8a49201dc29f
Autor:
Magali Champion, Kevin Brennan, Tom Croonenborghs, Andrew J. Gentles, Nathalie Pochet, Olivier Gevaert
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 156-166 (2018)
The availability of increasing volumes of multi-omics profiles across many cancers promises to improve our understanding of the regulatory mechanisms underlying cancer. The main challenge is to integrate these multiple levels of omics profiles and es
Externí odkaz:
https://doaj.org/article/e7ca88bede014fee8a3481f7d2f5569d
Autor:
Kevin Brennan, June Ho Shin, Joshua K. Tay, Marcos Prunello, Andrew J. Gentles, John B. Sunwoo, Olivier Gevaert
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Chromatin modifying enzymes are frequently mutated in cancer, resulting in widespread epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subtype of head and
Externí odkaz:
https://doaj.org/article/e80aabb014e14336a67aa59a1ef260a9
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-6 (2017)
Abstract In a recently published article in Genome Biology, Li and colleagues introduced TIMER, a gene expression deconvolution approach for studying tumor-infiltrating leukocytes (TILs) in 23 cancer types profiled by The Cancer Genome Atlas. Methods
Externí odkaz:
https://doaj.org/article/0d21d2f8c2404023bf5afc5bd75ab8a7
Autor:
David Stahl, Rainer Knoll, Andrew J. Gentles, Christian Vokuhl, Andreas Buness, Ines Gütgemann
Publikováno v:
Cancers, Vol 13, Iss 4, p 854 (2021)
Pediatric tumors frequently arise from embryonal cells, often displaying a stem cell-like (“small round blue”) morphology in tissue sections. Because recently “stemness” has been associated with a poor immune response in tumors, we investigat
Externí odkaz:
https://doaj.org/article/89e8b60c3f8f47d48197f825bf33bbc8
Autor:
Sandra Steyaert, Marija Pizurica, Divya Nagaraj, Priya Khandelwal, Tina Hernandez-Boussard, Andrew J. Gentles, Olivier Gevaert
Publikováno v:
Nature Machine Intelligence. 5:351-362
Autor:
Victoria G. Hernandez, Kendra J. Lechtenberg, Todd C. Peterson, Li Zhu, Tawaun A. Lucas, Karen P. Bradshaw, Justice O. Owah, Alanna I. Dorsey, Andrew J. Gentles, Marion S. Buckwalter
Publikováno v:
Glia.