Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrew J. Garton"'
Autor:
Richard Gedrich, Theresa M. LaVallee, Shannon Pankratz, E. Sergio Trombetta, Sreekala Mandiyan, Neal Janson, Linda Crew, Lori Lopresti-Morrow, Scott Seibel, Andrew J. Garton
The receptor tyrosine kinase KIT is an established oncogenic driver of tumor growth in certain tumor types, including gastrointestinal stromal tumors, in which constitutively active mutant forms of KIT represent an actionable target for small-molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4709b28b636fd77ce7446546c1c99717
https://doi.org/10.1158/1535-7163.c.6538696.v1
https://doi.org/10.1158/1535-7163.c.6538696.v1
Autor:
Richard Gedrich, Theresa M. LaVallee, Shannon Pankratz, E. Sergio Trombetta, Sreekala Mandiyan, Neal Janson, Linda Crew, Lori Lopresti-Morrow, Scott Seibel, Andrew J. Garton
Supplemental Figure S1A - Gating Plot Example for Identification of MDSC Populations in Spleen Samples (Pan02 Study); Supplemental Figure S1B - Gating Plot Example for Identification of T-Cell Populations in Tumor Samples (Pan02 Study); Supplemental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34945b0a4833e192ab76515e29437792
https://doi.org/10.1158/1535-7163.22507465
https://doi.org/10.1158/1535-7163.22507465
Autor:
Richard Gedrich, Theresa M. LaVallee, Gerald McMahon, Andrew J. Garton, Lori Lopresti-Morrow, Linda Crew, Krista La Perle, Gerald Post, Sarah Rippy, Heather L. Gardner, Cheryl A. London
Serum KTN0158 concentration over time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2cb449b9959ba6fe9bf6b2fea2e4da
https://doi.org/10.1158/1078-0432.22467360
https://doi.org/10.1158/1078-0432.22467360
Autor:
Richard Gedrich, Theresa M. LaVallee, Gerald McMahon, Andrew J. Garton, Lori Lopresti-Morrow, Linda Crew, Krista La Perle, Gerald Post, Sarah Rippy, Heather L. Gardner, Cheryl A. London
Purpose: KTN0158 is a novel anti-KIT antibody that potently inhibits wild-type and mutant KIT. This study evaluated the safety, biologic activity, and pharmacokinetic/pharmacodynamics profile of KTN0158 in dogs with spontaneous mast cell tumors (MCT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699154d93dde439561efde9489060fb3
https://doi.org/10.1158/1078-0432.c.6526620
https://doi.org/10.1158/1078-0432.c.6526620
Autor:
Richard Gedrich, Theresa M. LaVallee, Gerald McMahon, Andrew J. Garton, Lori Lopresti-Morrow, Linda Crew, Krista La Perle, Gerald Post, Sarah Rippy, Heather L. Gardner, Cheryl A. London
Table S1: KTN0158 Dosing Cohorts Table S2: Summary of Anti-KTN0158 Antibody Titers in Dogs with Mast Cell Tumors Following KTN0158 Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079e40c819885c8b4c21d2718002b16d
https://doi.org/10.1158/1078-0432.22467354.v1
https://doi.org/10.1158/1078-0432.22467354.v1
Autor:
Richard Gedrich, Theresa M. LaVallee, Gerald McMahon, Andrew J. Garton, Lori Lopresti-Morrow, Linda Crew, Krista La Perle, Gerald Post, Sarah Rippy, Heather L. Gardner, Cheryl A. London
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4678161d8038ea81c957cbc31b068b10
https://doi.org/10.1158/1078-0432.22467357
https://doi.org/10.1158/1078-0432.22467357
Autor:
Neil W. Gibson, Lee D. Arnold, Arlindo L. Castelhano, David L. Emerson, Frank Richardson, Tao Zhang, An-Hu Li, Regina Sennello, Karen Hart, Dwight Henninger, Bojana Vulevic, Anna Chan, Matthew O'Connor, Carrie Pirrit, Mary C. Srebernak, Chris Hidden, Paul Briner, John F. Keily, Mark A. Bittner, Eric N. Brown, April Franks, Shannon L. Winski, Jennifer Kahler, Linda Castaldo, Graham M. Wynne, Andrew R. Cooke, Maryland Franklin, Andrew P.A. Crew, Andrew J. Garton
Supplementary Figure Legends from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d345aaadab65f3803036dfbbb909af
https://doi.org/10.1158/0008-5472.22366926.v1
https://doi.org/10.1158/0008-5472.22366926.v1
Autor:
Channing J. Der, Sharon L. Campbell, Brianna Tokar, Xin Chen, Hanqing Dong, Jonathan A. Pachter, Linda Castaldo, Andrew J. Garton, Ana Plachco, Tai Young Kim, Dominico Vigil
PDF file - 65K, Supplementary Table 1. In vitro evaluation of the protein kinase inhibitory activities of the Y-27632 and OXA-6 ROCK1/2-selective small molecule inhibitors. Supplementary Figure 1. Comparison of OXA-6 and Y-26732 inhibition of PANC-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf7a28007fc62c8eff9f99221e10df8
https://doi.org/10.1158/0008-5472.22392636.v1
https://doi.org/10.1158/0008-5472.22392636.v1
Autor:
Neil W. Gibson, Lee D. Arnold, Arlindo L. Castelhano, David L. Emerson, Frank Richardson, Tao Zhang, An-Hu Li, Regina Sennello, Karen Hart, Dwight Henninger, Bojana Vulevic, Anna Chan, Matthew O'Connor, Carrie Pirrit, Mary C. Srebernak, Chris Hidden, Paul Briner, John F. Keily, Mark A. Bittner, Eric N. Brown, April Franks, Shannon L. Winski, Jennifer Kahler, Linda Castaldo, Graham M. Wynne, Andrew R. Cooke, Maryland Franklin, Andrew P.A. Crew, Andrew J. Garton
Supplementary Tables 1-2 from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce34b51937e71be251c0829e3f406e8
https://doi.org/10.1158/0008-5472.22366920
https://doi.org/10.1158/0008-5472.22366920
Autor:
Neil W. Gibson, Lee D. Arnold, Arlindo L. Castelhano, David L. Emerson, Frank Richardson, Tao Zhang, An-Hu Li, Regina Sennello, Karen Hart, Dwight Henninger, Bojana Vulevic, Anna Chan, Matthew O'Connor, Carrie Pirrit, Mary C. Srebernak, Chris Hidden, Paul Briner, John F. Keily, Mark A. Bittner, Eric N. Brown, April Franks, Shannon L. Winski, Jennifer Kahler, Linda Castaldo, Graham M. Wynne, Andrew R. Cooke, Maryland Franklin, Andrew P.A. Crew, Andrew J. Garton
Supplementary Figures 1-3 from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2466cc8df2c7445a3647818bc7207ba8
https://doi.org/10.1158/0008-5472.22366923.v1
https://doi.org/10.1158/0008-5472.22366923.v1