Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Andrew J. Gale"'
Autor:
Annette von Drygalski, Vikas Bhat, Andrew J Gale, Laurent Burnier, Thomas J Cramer, John H Griffin, Laurent O Mosnier
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104304 (2014)
An increased risk of bleeding is observed in patients receiving activated protein C (APC), which may be a limiting factor for the application of novel APC therapies. Since APC's therapeutic effects often require its cytoprotective activities on cells
Externí odkaz:
https://doaj.org/article/cdd6fb4b10ce476198d648be4dedd66c
Autor:
Ian Dransfield, Nicole D. Barth, Mary J. Heeb, John A. Marwick, Adriano G. Rossi, Andrew J. Gale
Publikováno v:
The Journal of Immunology. 201:2602-2611
Resolution of the inflammatory response requires coordinated regulation of pro- and anti-inflammatory mediator production, together with clearance of recruited inflammatory cells. Many different receptors have been implicated in phagocytosis of apopt
Autor:
Darlene J. Elias, Thomas J. Cramer, Laurent O. Mosnier, Annette von Drygalski, Andrew J. Gale, John H. Griffin, Vikas Bhat, Patricia M. Averell
Publikováno v:
Blood Adv
Control of bleeding with direct-acting oral anticoagulants (DOACs) remains an unmet clinical need. Activated superFactor V (superFVa) is an engineered activated protein C (APC)–resistant FVa variant with enhanced procoagulant activity resulting fro
Autor:
Wolfram Ruf, Sriram Krishnaswamy, Jennifer N. Orje, Andrew J. Gale, Andrea S. Rothmeier, Yu-ichi Kamikubo, Lars Christian Petersen, Zaverio M. Ruggeri, Antonella Zampolli, G. Loredana Mendolicchio, Patrizia Marchese, Henrik Østergaard, Andras Gruber
Publikováno v:
Blood. 130:1661-1670
Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation initiation complex can select
Autor:
Mohammed Khalifah, John H. Griffin, Kadijah Kurban, Fahad B Albadr, Andrew J. Gale, Abdulrahman Alsultan
Publikováno v:
Thrombosis Research. 143:17-21
We describe a family with two first-degree cousins who presented with similar phenotypes characterized by neonatal intracranial hemorrhage and subsequent onset of thrombosis.We enrolled the two affected patients, five unaffected family members and fi
Publikováno v:
Thrombosis and Haemostasis
Thrombosis and Haemostasis, Schattauer, 2017, 83 (01), pp.78-85. ⟨10.1055/s-0037-1613761⟩
Thrombosis and Haemostasis, Schattauer, 2017, 83 (01), pp.78-85. ⟨10.1055/s-0037-1613761⟩
SummaryThree dimensional homology models for the C1 and C2 domains of factor VIII (FVIII) were generated. Each C domain formed a β-sandwich, and C1 was covalently connected to C2 in a head-to-head orientation. Of the >250 missense mutations that cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3492e588e6e8c7d871d2bae8f843dcd8
https://hal.archives-ouvertes.fr/hal-03274036
https://hal.archives-ouvertes.fr/hal-03274036
Autor:
Brennen Arthur Lynch, Andrew K. Udit, Zinaida Polonskaya, Ho Yong Cheong, Kevin Hong, Andrew J. Gale, M. G. Finn, Myles Groner, Jin Kyu Rhee, Michael M. Baksh, William Hollingsworth
Publikováno v:
Biomacromolecules. 18(12)
The anticoagulant activity of heparin administered during medical interventions must be reversed to restore normal clotting, typically by titrating with protamine. Given the acute toxicity associated with protamine, we endeavored to generate safer he
Autor:
Alec Harootunian, Andrew J Gale, Stephen M. Baird, Steven L Chen, Roger Y. Tsien, Quyen T. Nguyen, Jesus E. Gonzalez, Marcel Miampamba, Junjie Liu
Publikováno v:
Theranostics, vol 7, iss 13
Theranostics
Theranostics
With the goal of improving intraoperative cancer visualization, we have developed AVB-620, a novel intravenously administered, in vivo fluorescent peptide dye conjugate that highlights malignant tissue and is optimized for human use. Matrix metallopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700fe29f1524d72a90f4bfea399d493a
https://escholarship.org/uc/item/7pd507jc
https://escholarship.org/uc/item/7pd507jc
Autor:
James C. Paulson, Corwin M. Nycholat, Matthew S. Macauley, Andrew J. Gale, Fabian Pfrengle, Annette von Drygalski, Christoph Rademacher
Publikováno v:
Journal of Clinical Investigation. 123:3074-3083
Antibodies confer humoral immunity but can also be harmful when they target an autoantigen, alloantigen, allergen, or biotherapeutic. New strategies are needed for antigen-specific suppression of undesired antibody responses, particularly to T cell-d
Publikováno v:
The FASEB Journal. 27:2918-2925
Protein S (PS) is a multifunctional plasma protein of the hemostatic and inflammatory pathways, although mechanisms for its regulation are poorly understood. Since certain plasma proteins are regulated through extracellular phosphorylation, we invest