Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Andrew J. Fluxe"'
Autor:
Michelle Hare, Jackson Christopher M, Bin Fang, Gina M. Fadayel, Richard Hedges, Michael Murawsky, Benjamin E. Blass, Jim Sheffer, Laurent Djandjighian, Ronald Eugene White, Andrew J. Fluxe, John Michael Janusz, Shengde Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6213-6218
A novel class of tetrazole-derived Kv1.5 blockers is disclosed. In in vitro studies, several compounds had IC50s ranging from 180 to 550 nM. In vivo studies indicated that compounds 2f and 2j increased right atrial ERP about 40% without affecting ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23ce66fd7f547364b8f2a57760b9d64
https://doi.org/10.1016/j.bmcl.2006.09.021
https://doi.org/10.1016/j.bmcl.2006.09.021
Autor:
Steve Hodson, Shengde Wu, Neil T. Fairweather, Andrew J. Fluxe, Benjamin E. Blass, Jim Ridgeway, John J. Janusz, Ronald Eugene White, Wenlin Lee, Keith R. Coburn, Jackson Christopher M
Publikováno v:
Tetrahedron Letters. 47:7497-7499
An examination of the methods required for the amination of 2- and 4-imidazolidinones is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fafb9bf3baa298e07e257239540be4a
https://doi.org/10.1016/j.tetlet.2006.08.022
https://doi.org/10.1016/j.tetlet.2006.08.022
Autor:
Ronald Eugene White, Laurent Djandjighian, Andrew J. Fluxe, John Michael Janusz, Shengde Wu, Steven J. Hodson, James M. Ridgeway, Benjamin E. Blass, Gina M. Fadayel, Keith R. Coburn, Jackson Christopher M, Michael Murawsky
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(1)
Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508dd9d9cdd8307bb20a62cf10dcf507
https://pubmed.ncbi.nlm.nih.gov/17095219
https://pubmed.ncbi.nlm.nih.gov/17095219
Autor:
Keith Cobum, Greg Browning, Andrew J. Fluxe, Laurent Djandjighian, John Michael Janusz, Richard Hedges, James B. Sheffer, Bin Fang, Shengde Wu, Gina M. Fadayel, Benjamin E. Blass, Michael Murawsky, Michelle Hare
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(22)
A novel class of tetrahydroindolone-derived semicarbazones has been discovered as potent Kv1.5 blockers. In in vitro studies, several compounds exhibited very good potency for blockade of Kv1.5. Compound 8i showed good selectivity for blockade of Kv1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dcc596ad71cd0eb6f8d7c91a7d45be
https://pubmed.ncbi.nlm.nih.gov/16942874
https://pubmed.ncbi.nlm.nih.gov/16942874
Autor:
Michelle Hare, James B. Sheffer, Shengde Wu, Andrew J. Fluxe, Laurent Djandjighian, Bin Fang, Michael Murawsky, Gina M. Fadayel, John Michael Janusz
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(22)
A novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and 29 are quite potent. They are also very selective over hERG (>450-fold) and L-type calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518b58d6ea27f2875d7236d186e72707
https://pubmed.ncbi.nlm.nih.gov/16942878
https://pubmed.ncbi.nlm.nih.gov/16942878
Autor:
Ronald Eugene White, Amanda L. Ritter, John Michael Janusz, Bin Fang, Wenlin Lee, Michael Murawsky, Benjamin E. Blass, Andrew J. Fluxe, Michelle Hare, Jim Ridgeway, Neil T. Fairweather, Keith R. Coburn, Jackson Christopher M, Laurent Djandjighian, Fred C. Wireko, Shengde Wu, Gina M. Fadayel, Richard Hedges
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(17)
A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2a5a21600156b3b618df2d75e9f923
https://pubmed.ncbi.nlm.nih.gov/16793267
https://pubmed.ncbi.nlm.nih.gov/16793267
Autor:
Andrew J. Fluxe, Peter Norris
Publikováno v:
Journal of Chemical Education. 78:1676
As the carbohydrates continue to gain attention for their central role in numerous areas of chemistry and biology, there is a growing need for experiments at the undergraduate level that highlight these fascinating compounds. In this article we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af161868af5c76566ef871449c2a61c2
https://doi.org/10.1021/ed078p1676
https://doi.org/10.1021/ed078p1676