Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrew J. Eszterhas"'
Autor:
Vera P. Krymskaya, Jerome H. Taylor, Reynold A. Panettieri, Dmitry A. Goncharov, Amelia Chisolm, Andrew J. Eszterhas, Poay N. Lim, Elena A. Goncharova, Homer W. Fogle
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 299:L25-L35
Severe asthma is characterized by increased airway smooth muscle (ASM) mass due, in part, to ASM cell growth and contractile protein expression associated with increased protein synthesis. Little is known regarding the combined effects of mitogens an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66cd3de937450bcb02f8f05f86d7b72
https://doi.org/10.1152/ajplung.00228.2009
https://doi.org/10.1152/ajplung.00228.2009
Autor:
Poay Lim, Andrew J. Eszterhas, Elena A. Goncharova, Vera P. Krymskaya, Reynold A. Panettieri, Dmitry A. Goncharov
Publikováno v:
Nature Protocols. 1:2905-2908
Vascular and airway remodeling, which are characterized by airway smooth muscle (ASM) and pulmonary arterial vascular smooth muscle (VSM) proliferation, contribute to the pathology of asthma, pulmonary hypertension, restenosis and atherosclerosis. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277d099c5d7f45881c9bcb93547d37ef
https://doi.org/10.1038/nprot.2006.433
https://doi.org/10.1038/nprot.2006.433
Autor:
Dmitriy A. Goncharov, Elena A. Goncharova, Daniel J. Noonan, Vera P. Krymskaya, Andrew J. Eszterhas, Ekaterina Talovskaya, Matthew Spaits
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 34:561-572
The TSC1 and TSC2 proteins, which function as a TSC1/TSC2 tumor suppressor complex, are associated with lymphangioleiomyomatosis (LAM), a genetic disorder characterized by the abnormal growth of smooth muscle-like cells in the lungs. The precise mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622ee35becb211ee49074caca53c45e1
https://doi.org/10.1165/rcmb.2005-0300oc
https://doi.org/10.1165/rcmb.2005-0300oc
Autor:
Vera P. Krymskaya, Andrew J. Eszterhas, Yassine Amrani, Omar Tliba, Chien Da Huang, Reynold A. Panettieri, Divaker Choubey, Aili L. Lazaar
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L1063-L1071
Elucidating the factors that inhibit the increase in airway smooth muscle (ASM) mass may be of therapeutic benefit in asthma. Here, we investigated whether interferon-γ (IFN-γ), a potent inducer of growth arrest in various cell types, regulates mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e929c0376bb341c498d02c1d941a3f
https://doi.org/10.1152/ajplung.00363.2002
https://doi.org/10.1152/ajplung.00363.2002
Autor:
Elena A. Goncharova, Deborah S. Hunter, Daniel J. Noonan, David J. Kwiatkowski, Reynold A. Panettieri, Dmitry A. Goncharov, Marilyn K. Glassberg, Cheryl L. Walker, Margaret M. Chou, Raymond S. Yeung, Andrew J. Eszterhas, Vera P. Krymskaya
Publikováno v:
Journal of Biological Chemistry. 277:30958-30967
Although the cellular functions ofTSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor suppressor gene are associated with tumor development in lymphangioleiomyomatosis (LAM). We found that ribosomal protein S6 (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::876684a21ca689c774941581cabe74cd
https://doi.org/10.1074/jbc.m202678200
https://doi.org/10.1074/jbc.m202678200
Autor:
Andrew J. Eszterhas, Reynold A. Panettieri, Jeffrey L. Benovic, Michael J. Orsini, Raymond B. Penn, Vera P. Krymskaya
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 277:L479-L488
Asthma is frequently associated with abnormal airway smooth muscle (ASM) growth that may contribute to airway narrowing and hyperresponsiveness to contractile agents. Although numerous hormones and cytokines have been shown to induce human ASM (HASM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db72fff0839f6758ab7c0008859fa9d
https://doi.org/10.1152/ajplung.1999.277.3.l479
https://doi.org/10.1152/ajplung.1999.277.3.l479
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 274:L417-L424
Airway smooth muscle (ASM) mass appears to be increased in the bronchi of patients with chronic severe asthma. Although the precise mechanisms that induce these changes are unknown, increases in ASM mass are caused, in part, by ASM cell proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e224f684bbe91e8f306c783c24dd081a
https://doi.org/10.1152/ajplung.1998.274.3.l417
https://doi.org/10.1152/ajplung.1998.274.3.l417
Autor:
Vincenzo Ciocca, Rebecca Hoffman, Reynold A. Panettieri, Andrew J. Eszterhas, Vera P. Krymskaya
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L1220-L1227
Regulation of phosphatidylinositol (PI) 3-kinase plays an important role in modulating cellular function. We have previously shown that transforming growth factor (TGF)-beta 1 inhibited epidermal growth factor (EGF)-induced human airway smooth muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db471bdff55531de515ec8594ee4bfd2
https://doi.org/10.1152/ajplung.1997.273.6.l1220
https://doi.org/10.1152/ajplung.1997.273.6.l1220
Publikováno v:
British Journal of Pharmacology. 118:191-197
1. In this study the mitogenic effects in human cultured tracheal smooth muscle cells of endothelin-1 (ET-1), ET-3, and sarafotoxin S6c (S6c), the ETB receptor-selective agonist, were explored either alone or in combination with the potent mitogen, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fec94d9a1714b2f5ed5064c9f33d5a
https://doi.org/10.1111/j.1476-5381.1996.tb15385.x
https://doi.org/10.1111/j.1476-5381.1996.tb15385.x
Autor:
Reynold A. Panettieri, Dmitry A. Goncharov, Alaina J. Ammit, Poay N. Lim, Elena A. Goncharova, Vera P. Krymskaya, Andrew J. Eszterhas
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(3)
Airway smooth muscle (ASM) hypertrophy and hyperplasia, important pathological features in chronic severe asthma, likely contribute to irreversible airflow obstruction. Despite considerable research effort, the precise cellular mechanisms that modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1d771d82c65614f2ff9ee1ce717d85
https://pubmed.ncbi.nlm.nih.gov/15746183
https://pubmed.ncbi.nlm.nih.gov/15746183