Macrophages Use Distinct Actin Regulators to Switch Engulfment Strategies and Ensure Phagocytic Plasticity In Vivo

Autor: Andrew J. Davidson, Will Wood

Publikováno v: Cell Reports, Vol 31, Iss 8, Pp - (2020)

Summary: Macrophages must not only be responsive to an array of different stimuli, such as infection and cellular damage, but also perform phagocytosis within the diverse and complex tissue environments found in vivo. This requires a high degree of m

Externí odkaz: https://doaj.org/article/56e728a02a2e46e9a030735c8d5108b4

Protocol for a double blind, randomised placebo-controlled trial using ondansetron to reduce vomiting in children receiving intranasal fentanyl and inhaled nitrous oxide for procedural sedation in the emergency department (the FON trial)

Autor: Emmanuelle Fauteux-Lamarre, Franz E Babl, Andrew J Davidson, Donna Legge, Katherine J Lee, Greta M Palmer, Sandy M Hopper

Publikováno v: BMJ Paediatrics Open, Vol 2, Iss 1 (2018)

Introduction Intranasal fentanyl and nitrous oxide (N2O) can be combined to create a non-parenteral procedural sedation regimen for children in the paediatric emergency department. This combination of intranasal fentanyl and N2O provides effective pa

Externí odkaz: https://doaj.org/article/a5df0ca69d3748c089f4100cc32e152e

Live cell tracking of macrophage efferocytosis during

Autor: Michael H, Raymond, Andrew J, Davidson, Yi, Shen, Daniel R, Tudor, Christopher D, Lucas, Sho, Morioka, Justin S A, Perry, Julia, Krapivkina, David, Perrais, Linus J, Schumacher, Robert E, Campbell, Will, Wood, Kodi S, Ravichandran

Publikováno v: Science (New York, N.Y.). 375(6585)

Apoptosis of cells and their subsequent removal through efferocytosis occurs in nearly all tissues during development, homeostasis, and disease. However, it has been difficult to track cell death and subsequent corpse removal in vivo. We developed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be72fce5199cc77243303d77c34f23e4
https://pubmed.ncbi.nlm.nih.gov/35271315

PTPN21/Pez is a novel and evolutionarily conserved key regulator of inflammation in vivo

Autor: Jennie S. Campbell, Henry Todd, David A. Lyons, Frederico S.L.M. Rodrigues, Abigail Elliot, Jason J Early, Yi Feng, Will Wood, Andrew J. Davidson

Publikováno v: Campbell, J S, Davidson, A J, Todd, H, Rodrigues, F S L M, Elliot, A M, Early, J J, Lyons, D A, Feng, Y & Wood, W 2020, ' PTPN21/Pez is a novel and evolutionarily conserved key regulator of inflammation in vivo ', Current Biology, vol. 31, pp. 1-9 . https://doi.org/10.1016/j.cub.2020.11.014
Current Biology

Summary Drosophila provides a powerful model in which to study inflammation in vivo, and previous studies have revealed many of the key signaling events critical for recruitment of immune cells to tissue damage. In the fly, wounding stimulates the ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77da1c4630ddc861e09d142cc65a720
https://www.pure.ed.ac.uk/ws/files/186325721/1_s2.0_S0960982220316894_main.pdf

WASP family proteins and formins compete in pseudopod- and bleb-based migration

Autor: Robert H. Insall, Clelia Amato, Andrew J. Davidson, Peter A. Thomason

Publikováno v: Davidson, A J, Amato, C, Thomason, P A & Insall, R H 2018, ' WASP family proteins and formins compete in pseudopod-and bleb-based migration ', Journal of Cell Biology, vol. 217, no. 2, pp. 701-714 . https://doi.org/10.1083/jcb.201705160
The Journal of Cell Biology

In migrating cells, actin underlies formation of pseudopods, filopods, and blebs. Davidson et al. use multiple knockouts in Dictyostelium to show that WASP family proteins SCAR/WAVE and WASP compete with the formin dDia2 for actin, influencing pseudo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2ff6dc3f8f40d6e7a87017c4ea977e
https://www.pure.ed.ac.uk/ws/files/139989513/Davidson_A_WASP_family_proteins....pdf