Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andrew J. Castiglioni"'
Autor:
Barbara Spix, Andrew J. Castiglioni, Natalie N. Remis, Emma N. Flores, Philipp Wartenberg, Amanda Wyatt, Ulrich Boehm, Thomas Gudermann, Martin Biel, Jaime García-Añoveros, Christian Grimm
Publikováno v:
PloS one. 17(12)
TRPML3 (mucolipin 3, MCOLN3) is an endolysosomal cation channel belonging to the TRPML subfamily of transient receptor potential channels. Gain-of-function mutations in the Trpml3 gene cause deafness, circling behavior and coat color dilution in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56405c0297c892ceac5fb7e46d1b35f9
https://pubmed.ncbi.nlm.nih.gov/36520788
https://pubmed.ncbi.nlm.nih.gov/36520788
Autor:
Natalie N Remis, Teerawat Wiwatpanit, Andrew J Castiglioni, Emma N Flores, Jorge A Cantú, Jaime García-Añoveros
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004833 (2014)
During the suckling period, intestinal enterocytes are richly endowed with endosomes and lysosomes, which they presumably utilize for the uptake and intracellular digestion of milk proteins. By weaning, mature intestinal enterocytes replace those ric
Externí odkaz:
https://doaj.org/article/4643d0567146439283b57983ac9f3efd
Publikováno v:
The Journal of Comparative Neurology. 519:1095-1114
TRPML3 is a member of the mucolipin branch of the transient receptor potential cation channel family. A dominant missense mutation in Trpml3 (also known as Mcoln3) causes deafness and vestibular impairment characterized by stereocilia disorganization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772defeabdb61b8ccb99af7e921fcc00
https://doi.org/10.1002/cne.22554
https://doi.org/10.1002/cne.22554
Autor:
Keiichi Nagata, Andrew J. Castiglioni, Jaime García-Añoveros, Thomas Madathany, Lili Zheng, James R. Bartles
Publikováno v:
Proceedings of the National Academy of Sciences. 105:353-358
Varitint-waddler (Va and Va J ) mice are deaf and have vestibular impairment, with inner ear defects that include the degeneration and loss of sensory hair cells. The semidominant Va mutation results in an alanine-to-proline substitution at residue 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faa354d79d5eb34e849f4ef7ed1d050
https://doi.org/10.1073/pnas.0707963105
https://doi.org/10.1073/pnas.0707963105
Publikováno v:
The Journal of Physiology. 576:119-134
N-type CaV2.2 calcium channels localize to presynaptic nerve terminals of nociceptors where they control neurotransmitter release. Nociceptive neurons express a unique set of ion channels and receptors important for optimizing their role in transmiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1745565f57cfc192375c0a989cdc36
https://doi.org/10.1113/jphysiol.2006.115030
https://doi.org/10.1113/jphysiol.2006.115030
Publikováno v:
Neuron. 41:127-138
N-type calcium channels are critical for pain transduction. Inhibitors of these channels are powerful analgesics, but clinical use of current N-type blockers remains limited by undesirable actions in other regions of the nervous system. We now demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1dd43983794a4849b1b7156c9a101b
https://doi.org/10.1016/s0896-6273(03)00801-8
https://doi.org/10.1016/s0896-6273(03)00801-8
Publikováno v:
Current topics in membranes. 59
Genetic and molecular searches in animals identify two families of ion channels used by specialized mechanosensory cells. These are the degenerin/epithelial Na+ channels (Deg/ENaCs) and transient receptor potential (TRP) channels. Some of these chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2992fdf9437082b3902b3ee16af94a4
https://pubmed.ncbi.nlm.nih.gov/25168138
https://pubmed.ncbi.nlm.nih.gov/25168138
Autor:
Andrew J. Castiglioni, Thomas D. Helton, Diane Lipscombe, Spiro Marangoudakis, Arturo Andrade, Sylvia Denome
Ca(V)2.2 (N-type) calcium channels control the entry of calcium into neurons to regulate essential functions but most notably presynaptic transmitter release. Ca(V)2.2 channel expression levels are precisely controlled, but we know little of the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3cd09d320d7d63d087a522a5bb9b92
https://europepmc.org/articles/PMC3428229/
https://europepmc.org/articles/PMC3428229/
Autor:
Kevin Chapman, Christophe Altier, Nathalie Vergnolle, Anthony H. Dickenson, Elizabeth A. Matthews, Camila Squarzoni Dale, Andrew J. Castiglioni, Gerald W. Zamponi, Alexandra E. Kisilevsky, Rhian M. Evans, Diane Lipscombe
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(24)
N-type calcium channels are essential mediators of spinal nociceptive transmission. The core subunit of the N-type channel is encoded by a single gene, and multiple N-type channel isoforms can be generated by alternate splicing. In particular, cell-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c713f783d4a2a6a28d0a4fd11db0426
https://pubmed.ncbi.nlm.nih.gov/17567797
https://pubmed.ncbi.nlm.nih.gov/17567797