Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrew J Olaharski"'
Autor:
Daniel Ness, Zhao Ren, Shyra Gardai, Douglas Sharpnack, Victor J Johnson, Richard J Brennan, Elizabeth F Brigham, Andrew J Olaharski
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66164 (2013)
Genetic evidence links mutations in the LRRK2 gene with an increased risk of Parkinson's disease, for which no neuroprotective or neurorestorative therapies currently exist. While the role of LRRK2 in normal cellular function has yet to be fully desc
Externí odkaz:
https://doaj.org/article/0e92e327929b407982215728de1da048
Autor:
Andrew J Olaharski, Nina Gonzaludo, Hans Bitter, David Goldstein, Stephan Kirchner, Hirdesh Uppal, Kyle Kolaja
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 7, p e1000446 (2009)
Kinases are heavily pursued pharmaceutical targets because of their mechanistic role in many diseases. Small molecule kinase inhibitors (SMKIs) are a compound class that includes marketed drugs and compounds in various stages of drug development. Whi
Externí odkaz:
https://doaj.org/article/58f86faf70b74e3f80297f583609f13a
The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases.
Autor:
Andrew J Olaharski, Jasper Rine, Brett L Marshall, Joshua Babiarz, Luoping Zhang, Eric Verdin, Martyn T Smith
Publikováno v:
PLoS Genetics, Vol 1, Iss 6, p e77 (2005)
Sirtuins are a family of phylogenetically conserved nicotinamide adenine dinucleotide-dependent deacetylases that have a firmly established role in aging. Using a simple Saccharomyces cerevisiae yeast heterochromatic derepression assay, we tested a n
Externí odkaz:
https://doaj.org/article/11dfc1c40e8246ecb4ad9f45b795960f
Autor:
Andrew J. Olaharski, Rohini Narayanaswamy, Janeta Popovici-Muller, Thomas P. Roddy, Lee Silverman, Raj Nagaraja, Gromoslaw A. Smolen, Stefan Gross, Christopher E. Mahoney, David Pirman
Publikováno v:
Toxicology and applied pharmacology. 401
Small cell lung cancer (SCLC) is a particularly aggressive subset of lung cancer, and identification of new therapeutic options is of significant interest. We recently reported that SCLC cell lines display a specific vulnerability to inhibition of sq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43527cd1156cc4bf21aff21aac877d41
https://pubmed.ncbi.nlm.nih.gov/32522582
https://pubmed.ncbi.nlm.nih.gov/32522582
Autor:
Hua Yang, Muriel D. David, Jeffrey O. Saunders, Lemieux Rene M, Gui Yao, Luke Utley, Véronique Saada, Xiaobing Lv, Yue Chen, Fang Wang, Shengfang Jin, Ping Chen, Erin Artin, Stéphane de Botton, Cheng Fang, Hyeryun Kim, Giovanni Cianchetta, Stefan Gross, Lenny Dang, Zhenwei Cai, Scott A. Biller, Andrew J. Olaharski, Erica Tobin, Cui Dawei, Katharine E. Yen, Virginie Penard-Lacronique, Liping Yan, Ding Zhou, Lee Silverman, Cyril Quivoron, Zhiyong Luo, Jeremy Travins, Janeta Popovici-Muller, Shinsan M. Su, Kimberly Straley, Zhiwei Gu, Francesco G. Salituro
Publikováno v:
ACS Medicinal Chemistry Letters
Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells, resulting in the production of d-2-hydroxyglutarate (2-HG), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0eaa35709cac29ca18fde3960dca69
https://doi.org/10.1021/acsmedchemlett.7b00421
https://doi.org/10.1021/acsmedchemlett.7b00421
Autor:
Anne Chester, Curtis Colleton, Michael J. Graziano, David O. Clarke, Peter Heining, David W. Brewster, Andrew J. Olaharski
Publikováno v:
Toxicologic Pathology. 44:458-466
The use of minipigs in preclinical safety testing of pharmaceuticals is considered an alternative to the more traditional dog and nonhuman primate (NHP) nonrodent species. Substantial evidence exists to suggest that the anatomy, physiology, and bioch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482e64815a4d650e7fbb82269ac5c458
https://doi.org/10.1177/0192623315617562
https://doi.org/10.1177/0192623315617562
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researche
Publikováno v:
Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe244f758f1bcc50592868ca91efc79
https://doi.org/10.1002/9781119053248
https://doi.org/10.1002/9781119053248
Autor:
Ivan N. Rich, Andrew J. Olaharski
Publikováno v:
Drug Discovery Toxicology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb85641219105f767d8477d94290b7cb
https://doi.org/10.1002/9781119053248.ch11
https://doi.org/10.1002/9781119053248.ch11
GADD45α induction in the greenscreen HC indicator assay does not occur independently of cytotoxicity
Autor:
Silvio Albertini, Lutz Mueller, Kyle L. Kolaja, Andrew J. Olaharski, Melanie Struwe, Andreas Zeller, Elmar Gocke
Publikováno v:
Environmental and Molecular Mutagenesis. 52:28-34
Mammalian chromosomal integrity assays are influenced by cytotoxicity, a phenomenon which impacts data interpretation, assay specificity, and regulatory testing guidelines. Concordance of the GADD45α GreenScreen HC indicator assay to established in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28590de90510339e34cae693be69704e
https://doi.org/10.1002/em.20565
https://doi.org/10.1002/em.20565