Patterns of care and outcomes of risk reducing surgery in women with pathogenic variants in non-BRCA and Lynch syndrome ovarian cancer susceptibility genes

Autor: Zachary P. Schwartz, Andrew J. Li, Christine S. Walsh, B.J. Rimel, Monica M. Alvarado, Scott E. Lentz, Ilana Cass

Publikováno v: Gynecologic Oncology. 173:1-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99691e53fabd2163d1bd6cebfb5a9ea5
https://doi.org/10.1016/j.ygyno.2023.03.017

Identification of Compounds for Butyrylcholinesterase Inhibition

Autor: Ruili Huang, Andrew J. Li, Carleen Klumpp-Thomas, Srilatha Sakamuru, Tuan Xu, Shuaizhang Li, Jameson Travers, Menghang Xia

Publikováno v: Slas Discovery

Butyrylcholinesterase (BChE) is a nonspecific cholinesterase enzyme that hydrolyzes choline-based esters. BChE plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (AChE) through hydrolyzing acetylcholine (ACh).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fdc5f754e89c651b64769b60f3bedd
http://europepmc.org/articles/PMC8637366

Therapy-induced senescence in breast cancer: an overview

Autor: Suraj Narayanan Chembukavu, Andrew J Lindsay

Publikováno v: Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 4, Pp 902-920 (2024)

Outcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present with intrinsic drug resistance and others are initially sensitive to anti-cancer drugs but acquire resistance during the course of thei

Externí odkaz: https://doaj.org/article/1abaed6f3abb40a2b7eb3d62dca53220

Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube

Autor: Andrew J. Li, Paul-Joseph Aspuria, Bj Rimel, Matthew T. Siedhoff, Kelly N. Wright, Simon A. Gayther, Lourdes Hernandez, Beth Y. Karlan, Fabiola Medeiros, Robbin Nameki, Marcela A. Haro, Huy Q. Dinh, Kate Lawrenson, Xianzhi Lin, Claire E. Olingy, Heidi Chang, Rosario I. Corona, Forough Abbasi

Publikováno v: Cell reports, vol 35, iss 2
Cell Rep
Cell Reports, Vol 35, Iss 2, Pp 108978-(2021)

Summary The human fallopian tube harbors the cell of origin for the majority of high-grade serous “ovarian” cancers (HGSCs), but its cellular composition, particularly the epithelial component, is poorly characterized. We perform single-cell tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a76c947a5bf77fb95d08728a092264
https://escholarship.org/uc/item/7hr243sx

Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers

Autor: Ana Osorio, Fiona Bruinsma, Andrew J. Li, Janine Senz, Stacey J. Winham, Michael E. Carney, Deborah J. Thompson, Xifeng Wu, Susan J. Ramus, Alicia A. Tone, Robert P. Edwards, Chu Chen, Daniel D. Buchanan, Rüdiger Klapdor, Diether Lambrechts, Anthony N. Karnezis, Ralf Bützow, Graham G. Giles, Jolanta Kupryjanczyk, James D. Brenton, Pamela J. Thompson, Joseph L. Kelley, Hui Cai, Dylan M. Glubb, Peter Hillemanns, Veronica Wendy Setiawan, Reidun K. Kopperud, Francesmary Modugno, Rodney J. Scott, Karen H. Lu, Andreas du Bois, Weiva Sieh, Clara Bodelon, Katharina Bischof, Sarah E. Ferguson, Ignace Vergote, Todd L. Edwards, Nadeem Siddiqui, Jennifer A. Doherty, Celeste Leigh Pearce, David G. Huntsman, Håkan Olsson, Ailith Ewing, Tjoung-Won Park-Simon, Harvey A. Risch, Taymaa May, Soo Hwang Teo, Elizabeth G. Holliday, Penelope M. Webb, Lukasz Michael Szafron, Alexander Hein, Martin Köbel, Marjorie J. Riggan, Madhuri Koti, Ahmad Alsulimani, Matthias W. Beckmann, Heli Nevanlinna, Domenico Palli, Melissa C. Larson, Emily White, Ingo B. Runnebaum, Robert A. Vierkant, Elza Khusnutdinova, Jolanta Lissowska, Andrew Berchuck, Rosalind Glasspool, Drakoulis Yannoukakos, Alison M. Dunning, Rosario Tumino, Mia M. Gaudet, Alice S. Whittemore, Anna Jakubowska, Marcus Q. Bernardini, Jennifer B. Permuth, Kunle Odunsi, Aleksandra Gentry-Maharaj, Florentia Fostira, Philipp Harter, Rebecca Sutphen, Sandra Orsulic, Beata Spiewankiewicz, Susanne K. Kjaer, Jessica N. McAlpine, Valerie McGuire, Julie M. Cunningham, Jeffrey Killeen, Christine M. Friedenreich, Estrid Høgdall, George Fountzilas, Michelle A.T. Hildebrandt, Katja K.H. Aben, Tomasz Huzarski, Frédéric Amant, Zhaoming Wang, James M. Flanagan, Timothy R. Rebbeck, Joseph H. Rothstein, Clemens Liebrich, Immaculata De Vivo, Linda Titus, Anna deFazio, Jan Gawełko, Irene Konstantopoulou, Adriaan Vanderstichele, Stephen J. Chanock, Jenny Lester, Amanda B. Spurdle, Allan Jensen, Claus Høgdall, Daniela Annibali, Amalia Mattiello, Peter Kraft, Loic Le Marchand, Line Bjørge, Marina Bermisheva, Agnieszka Podgorska, John Attia, Tracy A. O'Mara, Shashikant Lele, Thomas A. Sellers, Bo Gao, Holly R. Harris, Shan Wang-Gohrke, Lingeng Lu, Louise A. Brinton, Alessandra Macciotta, Digna R. Velez Edwards, Peter A. Fasching, Marc T. Goodman, Linda S. Cook, Constance Turman, Jacek Gronwald, Liv Cecilie Vestrheim Thomsen, Matthias Dürst, Kirsten B. Moysich, Usha Menon, Dong Liang, Arif B. Ekici, Bozena Konopka, Aurelio Barricarte, Thilo Dörk, Stefanie Burghaus, Michael Jones, Loren Lipworth, Zhihua Chen, Xiaoqing Chen, Alison Brand, Iain A. McNeish, Tanja Pejovic, Florian Heitz, Beth Y. Karlan, Anthony J. Swerdlow, Anna H. Wu

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention, 30, 1, pp. 217-228
Cancer Epidemiology, Biomarkers & Prevention, 30, 217-228
Cancer epidemiology, biomarkers & prevention, 30(1), 217-228. American Association for Cancer Research Inc.
Glubb, D M, Thompson, D J, Aben, K K, Alsulimani, A, Amant, F, Annibali, D, Attia, J, Barricarte, A, Beckmann, M W, Berchuck, A, Bermisheva, M, Bernardini, M Q, Bischof, K, Bjørge, L, Bodelon, C, Brand, A H, Brenton, J D, Brinton, L A, Bruinsma, F, Buchanan, D D, Burghaus, S, Bützow, R, Cai, H, Carney, M E, Chanock, S J, Chen, C, Chen, X, Chen, Z, Cook, L S, Cunningham, J M, De Vivo, I, Defazio, A, Doherty, J A, Dork, T, Du Bois, A, Dunning, A M, Durst, M, Edwards, T, Edwards, R P, Ekici, A B, Ewing, A, Fasching, P A, Ferguson, S, Flanagan, J M, Fostira, F, Fountzilas, G, Friedenreich, C M, Gao, B, Gaudet, M M, Gawełko, J, Gentry-maharaj, A, Giles, G G, Glasspool, R, Goodman, M T, Gronwald, J, Harris, H R, Harter, P, Hein, A, Heitz, F, Hildebrandt, M A T, Hillemanns, P, Høgdall, E, Høgdall, C K, Holliday, E G, Huntsman, D G, Huzarski, T, Jakubowska, A, Jensen, A, Jones, M E, Karlan, B Y, Karnezis, A, Kelley, J L, Khusnutdinova, E, Killeen, J L, Kjaer, S K, Klapdor, R, Köbel, M, Konopka, B, Konstantopoulou, I, Kopperud, R K, Koti, M, Kraft, P, Kupryjanczyk, J, Lambrechts, D, Larson, M C, Le Marchand, L, Lele, S, Lester, J, Li, A J, Liang, D, Liebrich, C, Lipworth, L, Lissowska, J, Lu, L, Lu, K H, Macciotta, A, Mattiello, A, May, T, Mcalpine, J N, Mcguire, V, Mcneish, I A, Menon, U, Modugno, F, Moysich, K B, Nevanlinna, H, Odunsi, K, Olsson, H, Orsulic, S, Osorio, A, Palli, D, Park-simon, T, Pearce, C L, Pejovic, T, Permuth, J B, Podgorska, A, Ramus, S J, Rebbeck, T R, Riggan, M J, Risch, H A, Rothstein, J H, Runnebaum, I B, Scott, R J, Sellers, T A, Senz, J, Setiawan, V W, Siddiqui, N, Sieh, W, Spiewankiewicz, B, Sutphen, R, Swerdlow, A J, Szafron, L M, Teo, S H, Thompson, P J, Thomsen, L C V, Titus, L, Tone, A, Tumino, R, Turman, C, Vanderstichele, A, Velez Edwards, D, Vergote, I, Vierkant, R A, Wang, Z, Wang-gohrke, S, Webb, P M, White, E, Whittemore, A S, Winham, S J, Wu, X, Wu, A H, Yannoukakos, D, Spurdle, A B & O'mara, T A 2021, ' Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers. ', Cancer Epidemiology, Biomarkers & Prevention, vol. 30, no. 1, cebp.0739.2020, pp. 217-228 . https://doi.org/10.1158/1055-9965.EPI-20-0739

Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05013621ea6b2cd03a98c84750051500
https://hdl.handle.net/2066/231075