Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andrew J Knights"'
Autor:
Leopold Parts, Åsa K Hedman, Sarah Keildson, Andrew J Knights, Cei Abreu-Goodger, Martijn van de Bunt, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Reedik Mägi, James Nisbet, Amy Barrett, Mattias Rantalainen, Alexandra C Nica, Michael A Quail, Kerrin S Small, Daniel Glass, Anton J Enright, John Winn, MuTHER Consortium, Panos Deloukas, Emmanouil T Dermitzakis, Mark I McCarthy, Timothy D Spector, Richard Durbin, Cecilia M Lindgren
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002704 (2012)
Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population. Here, we characterise
Externí odkaz:
https://doaj.org/article/567b690c4f6542dca39e9f68d18a18a2
Autor:
Clara Alsinet, Maria Nascimento Primo, Valentina Lorenzi, Erica Bello, Iva Kelava, Carla P. Jones, Roser Vilarrasa-Blasi, Carmen Sancho-Serra, Andrew J. Knights, Jong-Eun Park, Beata S. Wyspianska, Gosia Trynka, David F. Tough, Andrew Bassett, Daniel J. Gaffney, Damiana Alvarez-Errico, Roser Vento-Tormo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The myeloid lineage is central to homeostasis and immunity. The authors provide an atlas of human iPSC-to-myeloid cell differentiation and demonstrate that the in vitro system recapitulates yolk sac differentiation, opening new avenues to human myelo
Externí odkaz:
https://doaj.org/article/ff14b8d69b054e38a5e0e2b1247d1b45
Autor:
Mara K. N. Lawniczak, Martin Hemberg, Maria Imaz, Richard Durbin, Arthur M. Talman, Andrew J Knights, Haynes Heaton, Daniel J. Gaffney
Publikováno v:
Nature Methods. 17:615-620
Methods to deconvolve single-cell RNA-sequencing (scRNA-seq) data are necessary for samples containing a mixture of genotypes, whether they are natural or experimentally combined. Multiplexing across donors is a popular experimental design that can a
Autor:
Anna Wilbrey-Clark, Vitalii Kleshchevnikov, Nathan Richoz, Ana Ribeiro Orsi, Liam Bolt, Lira Mamanova, Sophie Pritchard, Rasa Elmentaite, Natsuhiko Kumasaka, Minal Patel, Kourosh Saeb-Parsy, Sara F. Vieira, Adam Hunter, Menna R. Clatworthy, Elo Madissoon, Peng He, Monika Dabrowska, Agnes Oszlanczi, Elena Prigmore, Andrew J Knights, Oliver Stegle, Liz Tuck, Ni Huang, Nikitas Georgakopoulos, Omer Ali Bayraktar, Krzysztof Polanski, Kerstin B. Meyer, Krishnaa T. Mahbubani, J. Patrick Pett, Sarah A. Teichmann, Amanda Oliver
SummaryMultiple distinct cell types of the human lung and airways have been defined by single cell RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define novel cell types which we map back into the macro- and micro-anat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b89f02ae2bc2e1b29bc78b842ac3fc65
https://doi.org/10.1101/2021.11.26.470108
https://doi.org/10.1101/2021.11.26.470108
Autor:
Clara Alsinet, Carmen Sancho-Serra, Andrew J Knights, Jong-Eun Park, Roser Vento-Tormo, Valentina Lorenzi, Damiana Alvarez, Maria Primo, Daniel J. Gaffney, Beata S Wyspianska, David F. Tough
SummaryMyeloid cells have a central role in homeostasis and tissue defence. Characterising the current in vitro protocols of myelopoiesis is imperative for their use in research and immunotherapy as well as for understanding the early stages of myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::542bcfa1c6e28250342de1d95a60c95f
https://doi.org/10.1101/2021.11.17.469005
https://doi.org/10.1101/2021.11.17.469005
Autor:
Richard Mannion, Andrew J Knights, Beth Stevens, Ivan Timofeev, Rikin A. Trivedi, Mathew R. Guilfoyle, Ibrahim Jalloh, Jeremy Schwartzentruber, Nicole Soranzo, Kousik Kundu, Peter J. Hutchinson, Daniel J. Gaffney, Natsuhiko Kumasaka, Jimmy Z. Liu, Richard Mair, Natalia A. Murphy, Adam Young, Maya Ghoussaini, Fiona Calvert, Alexis J Joannides, Omer Ali Bayraktar, Robert H. Morris, Christopher E McMurran, Colin Watts, Karol P. Budohoski, Michael Segel, Robin J.M. Franklin, Edward Mountjoy, Thomas Santarius, Jason Correia, Stephen J. Price, Peter J. Kirkpatrick, Katherine Holland, Harry Bulstrode, Ramez W. Kirollos, Nikolaos Panousis, Matthew R. Garnett, Timothy R. Hammond, Jun Sung Park
Microglia, the tissue-resident macrophages of the central nervous system (CNS), play critical roles in immune defense, development and homeostasis. However, isolating microglia from humans in large numbers is challenging. Here, we profiled gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33608e469cea0644f56d0749e0d23993
https://www.repository.cam.ac.uk/handle/1810/325436
https://www.repository.cam.ac.uk/handle/1810/325436
Autor:
Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J. Knights, Mercedes Pardo, Lu Yu, Jyoti S. Choudhary, Emmanouil Metzakopian, Vivek Iyer, Haiyang Yun, Naomi Park, Ignacio Varela, Ruben Bautista, Grace Collord, Oliver Dovey, Dimitrios A. Garyfallos, Etienne De Braekeleer, Saki Kondo, Jonathan Cooper, Berthold Göttgens, Lars Bullinger, Paul A. Northcott, David Adams, George S. Vassiliou, Brian J. P. Huntly
Publikováno v:
Nature Genetics. 54:1062-1062
Publikováno v:
Nature genetics
Physical interaction of regulatory elements in three-dimensional space poses a challenge for studies of disease because non-coding risk variants may be great distances from the genes they regulate. Experimental methods to capture these interactions,
Autor:
Rachel A. Botting, Lira Mamanova, Austen Lamacraft, Krzysztof Polanski, Andrew J Knights, Muzlifah Haniffa, Cecilia Domínguez Conde, Xi Chen, Jong-Eun Park, Mika Sarkin Jain, Mirjana Efremova, Sarah A. Teichmann, Emily Stephenson
Multimodal data is rapidly growing in many fields of science and engineering, including single-cell biology. We introduce MultiMAP, an approach for dimensionality reduction and integration of multiple datasets. MultiMAP recovers a single manifold on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d12c5f54adb008d31e78a1ed0355be6
https://doi.org/10.1101/2021.02.16.431421
https://doi.org/10.1101/2021.02.16.431421
Autor:
Anna S E Cuomo, Iker Martinez, Ludovic Vallier, Pedro Madrigal, Oliver Stegle, Andrew J Knights, Kedar Nath Natarajan, Shradha Amatya, Florian Buettner, Mariya Chhatriwala, John C. Marioni, Daniel D Seaton, Marc Jan Bonder, Abigail Isaacson, Davis J. McCarthy, Jose Garcia-Bernardo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications
Nature Communications
Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals and, in particular, the influence