Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Andrew J Kassianos"'
Autor:
Muhammad Ali Khan MPharm, Andrew J Kassianos PhD, Wendy E Hoy MD, AHM Khurshid Alam PhD, Helen G Healy MD, Glenda C Gobe PhD
Publikováno v:
Journal of Evidence-Based Integrative Medicine, Vol 27 (2022)
Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current
Externí odkaz:
https://doaj.org/article/8587d04c760d41e09036ccbf4d5747d4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Chronic kidney disease (CKD) is the progressive loss of kidney function/structure over a period of at least 3 months. It is characterised histologically by the triad of cell loss, inflammation and fibrosis. This literature review focuses on the forms
Externí odkaz:
https://doaj.org/article/bff684eed2e6487aa77f45cc5c5604fa
Autor:
Sandeep Sampangi, Andrew J Kassianos, Xiangju Wang, Kenneth W Beagley, Travis Klein, Sadia Afrin, Helen Healy, Ray Wilkinson
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134688 (2015)
Proximal tubule epithelial cells (PTEC) of the kidney line the proximal tubule downstream of the glomerulus and play a major role in the re-absorption of small molecular weight proteins that may pass through the glomerular filtration process. In the
Externí odkaz:
https://doaj.org/article/8ce69e093c894a93984f501f6a62b0fa
Autor:
Ray Wilkinson, Xiangju Wang, Andrew J Kassianos, Steven Zuryn, Kathrein E Roper, Andrew Osborne, Sandeep Sampangi, Leo Francis, Vishwas Raghunath, Helen Healy
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87345 (2014)
Interstitial fibrosis, a histological process common to many kidney diseases, is the precursor state to end stage kidney disease, a devastating and costly outcome for the patient and the health system. Fibrosis is historically associated with chronic
Externí odkaz:
https://doaj.org/article/9841129d5b174259b8ad15be40b12cd1
Autor:
Xiangju Wang, Chang Seong Kim, Benjamin C. Adams, Ray Wilkinson, Michelle M. Hill, Alok K. Shah, Ahmed Mohamed, Mriga Dutt, Monica S.Y. Ng, Jacobus P.J. Ungerer, Helen G. Healy, Andrew J. Kassianos
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103042- (2024)
Hypoxia is the key pathobiological trigger of tubular oxidative stress and cell death that drives the transition of acute kidney injury (AKI) to chronic kidney disease (CKD). The mitochondrial-rich proximal tubular epithelial cells (PTEC) are uniquel
Externí odkaz:
https://doaj.org/article/898c2efbe8a34d2eb160c44c13860921
Autor:
Arti M. Raghubar, Nicholas A. Matigian, Joanna Crawford, Leo Francis, Robert Ellis, Helen G. Healy, Andrew J. Kassianos, Monica S. Y. Ng, Matthew J. Roberts, Simon Wood, Andrew J. Mallett
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Perioperative immune checkpoint inhibitor (ICI) trials for intermediate high-risk clear cell renal cell carcinoma (ccRCC) have failed to consistently demonstrate improved patient outcomes. These unsuccessful ICI trials suggest that the tumou
Externí odkaz:
https://doaj.org/article/61bde8200489472a9c91dfe298700bf9
Autor:
Kurt T. K. Giuliani, Anca Grivei, Purba Nag, Xiangju Wang, Melissa Rist, Katrina Kildey, Becker Law, Monica S. Ng, Ray Wilkinson, Jacobus Ungerer, Josephine M. Forbes, Helen Healy, Andrew J. Kassianos
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-13 (2022)
Abstract Inflammasomes are multiprotein platforms responsible for the release of pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Mouse studies have identified inflammasome activation within dendritic cells (DC) as pivotal for driving tubul
Externí odkaz:
https://doaj.org/article/3f6627c645814f06a5a8676f3b366cb9
Autor:
Arti M. Raghubar, Matthew J. Roberts, Simon Wood, Helen G. Healy, Andrew J. Kassianos, Andrew J. Mallett
Publikováno v:
Frontiers in Oncology. 12
Clear cell renal cell carcinoma (ccRCC) is globally the most prevalent renal cancer. The cells of origin in ccRCC have been identified as proximal tubular epithelial cells (PTEC); however, the transcriptomic pathways resulting in the transition from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00607fdc24885af5dfe12ff7064f192b
https://doi.org/10.3389/fonc.2022.943583
https://doi.org/10.3389/fonc.2022.943583
Autor:
Matthew Tunbridge, Anca Grivei, Andrew J. Kassianos, Helen Davis, Anne Stewart, Helen Healy, Saw Yu Mon, George T. John
Publikováno v:
Nephrology. 27:908-909
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2bbac95c0e89fd0e693ac87d3b8350e
https://doi.org/10.1111/nep.14104
https://doi.org/10.1111/nep.14104
Autor:
Anca Grivei, Xiangju Wang, Kurt T. K. Giuliani, Pedro F. H. Gois, Kirsten Hepburn, George John, Jacobus P.J. Ungerer, Helen Healy, L. Francis, Andrew J. Kassianos
Publikováno v:
Free Radical Biology and Medicine. 160:690-695
Acute kidney injury (AKI) is a life-threatening complication of rhabdomyolysis. The pathophysiological mechanisms of rhabdomyolysis-induced AKI (RIAKI) have been extensively studied in the murine system, yet clinical translation of this knowledge to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fa5e27459533aaa6f6cef2a4a539a0
https://doi.org/10.1016/j.freeradbiomed.2020.09.011
https://doi.org/10.1016/j.freeradbiomed.2020.09.011