Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Andrew J Haak"'
Autor:
Aja Aravamudhan, Paul B. Dieffenbach, Kyoung Moo Choi, Patrick A. Link, Jeffrey A. Meridew, Andrew J. Haak, Laura E. Fredenburgh, Daniel J. Tschumperlin
Publikováno v:
Physiological Reports, Vol 12, Iss 7, Pp n/a-n/a (2024)
Abstract Pulmonary arterial hypertension (PAH) causes pulmonary vascular remodeling, increasing pulmonary vascular resistance (PVR) and leading to right heart failure and death. Matrix stiffening early in the disease promotes remodeling in pulmonary
Externí odkaz:
https://doaj.org/article/aebdd8312bac4e3da3890b481db20877
Autor:
Samuel C. Buchl, Zachary Hanquier, Andrew J. Haak, Yvonne M. Thomason, Robert C. Huebert, Vijay H. Shah, Jessica L. Maiers
Publikováno v:
Hepatology Communications, Vol 6, Iss 3, Pp 593-609 (2022)
Hepatic fibrosis is driven by deposition of matrix proteins following liver injury. Hepatic stellate cells (HSCs) drive fibrogenesis, producing matrix proteins, including procollagen I, which matures into collagen I following secretion. Disrupting in
Externí odkaz:
https://doaj.org/article/bcafa6911f9b4aaba6a84b3f78a8b036
Autor:
Marissa J. Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti, Elizabeth J. Atkinson, Ann L. Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L. Mazula, Robert W. Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y. S. Prakash, Tamara Tchkonia, Paul D. Robbins, Marie Christine Aubry, João F. Passos, James L. Kirkland, Daniel J. Tschumperlin, Hirohito Kita, Nathan K. LeBrasseur
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fib
Externí odkaz:
https://doaj.org/article/24b84bad3904485caad4533a2d6fd946
Publikováno v:
Survey of Ophthalmology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e390a4a7040343695d7a0880d5c178e3
https://doi.org/10.1016/j.survophthal.2023.05.007
https://doi.org/10.1016/j.survophthal.2023.05.007
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
To show that MRTF-A localization was dependent on F-actin dynamics, we stimulated SK-Mel-19 cells with 20% FBS to induce stress fiber formation which induced MRTF-A nuclear localization. We also treated SK-Mel-147 cells with latrunculin B which inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1117c9e2a1495f7253941a73c0d5452d
https://doi.org/10.1158/1535-7163.22508319
https://doi.org/10.1158/1535-7163.22508319
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
The Cancer Genome Atlas (TCGA) cutaneous melanoma dataset was stratified into quartiles based upon expression of indicated genes. Kaplan-Meier plots were generated from the highest (grey) and lowest (black) expressing quartiles. Survival curves were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412fad174ba69ff2635cf96a88d4e660
https://doi.org/10.1158/1535-7163.22508322.v1
https://doi.org/10.1158/1535-7163.22508322.v1
Autor:
Kalpana R. Betageri, Patrick A. Link, Andrew J. Haak, Giovanni Ligresti, Daniel J. Tschumperlin, Nunzia Caporarello
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology.
Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations, and increased vascular perme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a96bd6bf53f32f1c7440def6364ce2
https://pubmed.ncbi.nlm.nih.gov/36573684
https://pubmed.ncbi.nlm.nih.gov/36573684
Autor:
Jack H Wellmerling, Sara R Dresler, Jeffrey A Meridew, Kyoung M Choi, Andrew J Haak, Daniel J Tschumperlin, Qi Tan
Background Idiopathic pulmonary fibrosis (IPF) is characterized by pathological accumulation of scar tissue in the lung parenchyma. Many of the processes that are implicated in fibrosis, such as matrix deposition also occur following pneumonectomy (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7165c3d773e1c5ad24f0c140d93c7ab8
https://doi.org/10.21203/rs.3.rs-2306746/v1
https://doi.org/10.21203/rs.3.rs-2306746/v1
Autor:
Ashley Y. Gao, Ana M. Diaz Espinosa, Fiorenza Gianì, Tho X. Pham, Chase M. Carver, Aja Aravamudhan, Colleen M. Bartman, Giovanni Ligresti, Nunzia Caporarello, Marissa J. Schafer, Andrew J. Haak
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology.
Cellular senescence is emerging as a driver of idiopathic pulmonary fibrosis (IPF), a progressive and fatal disease with limited effective therapies. The senescence-associated secretory phenotype (SASP), involving the release of inflammatory cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b58b4b2bcf56c6b993b374a63373f3d
https://pubmed.ncbi.nlm.nih.gov/36223640
https://pubmed.ncbi.nlm.nih.gov/36223640
Autor:
Ashley Gao, Ana M Diaz Espinosa, Ba Bao N Nguyen, Patrick A Link, Jeffrey Meridew, Dakota L Jones, Daniel F Gibbard, Daniel Tschumperlin, Andrew J Haak
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b6f8ecb213a5199c0ee729684046c75
https://doi.org/10.1124/jpet.122.001442
https://doi.org/10.1124/jpet.122.001442