Výsledky vyhledávání - "Andrew J Grimm"

Akademický článek

Correction: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission.

Autor: Mykola Pinkevych, Deborah Cromer, Martin Tolstrup, Andrew J Grimm, David A Cooper, Sharon R Lewin, Ole S Søgaard, Thomas A Rasmussen, Stephen J Kent, Anthony D Kelleher, Miles P Davenport

Publikováno v: PLoS Pathogens, Vol 12, Iss 8, p e1005745 (2016)

[This corrects the article DOI: 10.1371/journal.ppat.1005000.][This corrects the article DOI: 10.1371/journal.ppat.1005740.][This corrects the article DOI: 10.1371/journal.ppat.1005679.].

Externí odkaz: https://doaj.org/article/aee3375d000b4b78b5d8debd68e38d04

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Akademický článek

HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remission.

Autor: Mykola Pinkevych, Deborah Cromer, Martin Tolstrup, Andrew J Grimm, David A Cooper, Sharon R Lewin, Ole S Søgaard, Thomas A Rasmussen, Stephen J Kent, Anthony D Kelleher, Miles P Davenport

Publikováno v: PLoS Pathogens, Vol 11, Iss 7, p e1005000 (2015)

HIV infection can be effectively controlled by anti-retroviral therapy (ART) in most patients. However therapy must be continued for life, because interruption of ART leads to rapid recrudescence of infection from long-lived latently infected cells.

Externí odkaz: https://doaj.org/article/12051d94ba6b47829af0a7b108717023

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Akademický článek

Accurately measuring recombination between closely related HIV-1 genomes.

Autor: Timothy E Schlub, Redmond P Smyth, Andrew J Grimm, Johnson Mak, Miles P Davenport

Publikováno v: PLoS Computational Biology, Vol 6, Iss 4, p e1000766 (2010)

Retroviral recombination is thought to play an important role in the generation of immune escape and multiple drug resistance by shuffling pre-existing mutations in the viral population. Current estimates of HIV-1 recombination rates are derived from

Externí odkaz: https://doaj.org/article/91afb1af0757412a9f5ad20004a08a53

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Epitope-Specific CD8+ T Cell Kinetics Rather than Viral Variability Determine the Timing of Immune Escape in Simian Immunodeficiency Virus Infection

Autor: Jeanette C. Reece, Shayarana L. Gooneratne, Hamid Alinejad-Rokny, Janka Petravic, Alexey Martyushev, Andrew J. Grimm, Miles P. Davenport, Deborah Cromer, Stephen J. Kent

Publikováno v: The Journal of Immunology. 194:4112-4121

CD8+ T cells are important for the control of chronic HIV infection. However, the virus rapidly acquires “escape mutations” that reduce CD8+ T cell recognition and viral control. The timing of when immune escape occurs at a given epitope varies w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caa32ccf38a5b4e995a3f887dd90de0
https://doi.org/10.4049/jimmunol.1400793

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HIV-1 Mutation and Recombination Rates Are Different in Macrophages and T-cells

Autor: Abha Chopra, Simon Mallal, Deborah Cromer, Timothy E. Schlub, Miles P. Davenport, Redmond P. Smyth, Andrew J. Grimm, Johnson Mak

Publikováno v: Viruses
Viruses; Volume 8; Issue 4; Pages: 118
Viruses, MDPI, 2016, 8 (4), pp.118. ⟨10.3390/v8040118⟩
Viruses, Vol 8, Iss 4, p 118 (2016)

High rates of mutation and recombination help human immunodeficiency virus (HIV) to evade the immune system and develop resistance to antiretroviral therapy. Macrophages and T-cells are the natural target cells of HIV-1 infection. A consensus has not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33244744e23aa5fcc3f0d4c598379387
http://europepmc.org/articles/PMC4848610

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Estimating the in-vivo HIV template switching and recombination rate

Autor: Deborah Cromer, Miles P. Davenport, Andrew J. Grimm, Timothy E. Schlub, Johnson Mak

Publikováno v: AIDS (London, England). 30(2)

Background: HIV recombination has been estimated in vitro using a variety of approaches, and shows a high rate of template switching per reverse transcription event. In-vivo studies of recombination generally measure the accumulation of recombinant s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222bc7e95b2f9054240d6170c097011b
https://pubmed.ncbi.nlm.nih.gov/26691546

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Reducing chimera formation during PCR amplification to ensure accurate genotyping

Autor: Abha Chopra, Simon Mallal, Johnson Mak, Miles P. Davenport, Vanessa Venturi, Redmond P. Smyth, Timothy E. Schlub, Andrew J. Grimm

Publikováno v: Gene. 469:45-51

Measurements of population diversity are fundamental to the reconstruction of the evolutionary and epidemiological history of organisms. Commonly used protocols to measure population diversity using the polymerase chain reaction (PCR) are prone to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044f60a47c23bc7df825e4f75c6aeb3f
https://doi.org/10.1016/j.gene.2010.08.009

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HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remission

Autor: David A. Cooper, Sharon R Lewin, Deborah Cromer, Martin Tolstrup, Anthony D. Kelleher, Stephen J. Kent, Thomas A Rasmussen, Miles P. Davenport, Ole S. Søgaard, Mykola Pinkevych, Andrew J. Grimm

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 7, p e1005000 (2015)
Pinkevych, M, Cromer, D, Tolstrup, M, Grimm, A J, Cooper, D A, Lewin, S R, Søgaard, O S, Rasmussen, T A, Kent, S J, Kelleher, A D & Davenport, M P 2015, ' HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remission ', P L o S Pathogens, vol. 11, no. 7, pp. e1005000 . https://doi.org/10.1371/journal.ppat.1005000

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2daa143eae46916fda5c31bd8279adf
https://pubmed.ncbi.nlm.nih.gov/27561082

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Fifteen to Twenty Percent of HIV Substitution Mutations Are Associated with Recombination

Autor: Abha Chopra, Simon Mallal, Miles P. Davenport, Deborah Cromer, Redmond P. Smyth, Andrew J. Grimm, Caryll Waugh, Timothy E. Schlub, Johnson Mak, Vanessa Venturi

HIV undergoes high rates of mutation and recombination during reverse transcription, but it is not known whether these events occur independently or are linked mechanistically. Here we used a system of silent marker mutations in HIV and a single roun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4721a55b168fc2e54770eacf5bbbe100
https://europepmc.org/articles/PMC3993552/

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Measuring turnover of SIV DNA in resting CD4+ T cells using pyrosequencing: implications for the timing of HIV eradication therapies

Autor: Thakshila Amaresena, Liyen Loh, Miles P. Davenport, Jeanette C. Reece, Robert De Rose, Alexey Martyushev, Stephen J. Kent, Janka Petravic, Andrew J. Grimm, Shayarana L. Gooneratne

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93330 (2014)
PLoS ONE

Resting CD4+ T cells are a reservoir of latent HIV-1. Understanding the turnover of HIV DNA in these cells has implications for the development of eradication strategies. Most studies of viral latency focus on viral persistence under antiretroviral t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0705521b6be720124522bde76612efa
http://europepmc.org/articles/PMC3977820?pdf=render

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