Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Andrew J Gentles"'
Autor:
Renumathy Dhanasekaran, Virginie Baylot, Minsoon Kim, Sibu Kuruvilla, David I Bellovin, Nia Adeniji, Anand Rajan KD, Ian Lai, Meital Gabay, Ling Tong, Maya Krishnan, Jangho Park, Theodore Hu, Mustafa A Barbhuiya, Andrew J Gentles, Kasthuri Kannan, Phuoc T Tran, Dean W Felsher
Publikováno v:
eLife, Vol 9 (2020)
Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice. MYC and Twist1 cooperate and
Externí odkaz:
https://doaj.org/article/70e4719673194a84a60d73e0f1a3b836
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
Ewing´s Sarcoma Family of Tumors (ESFT) are clinically aggressive bone and soft tissue tumors in children and young adults. Analysis of the immune tumor microenvironment (TME) provides insight into tumor evolution and novel treatment options. So far
Externí odkaz:
https://doaj.org/article/acda76cb94f54ca68d52f7fc70747dc0
Autor:
Brian S. White, Aurélien de Reyniès, Aaron M. Newman, Joshua J. Waterfall, Andrew Lamb, Florent Petitprez, Yating Lin, Rongshan Yu, Martin E. Guerrero-Gimenez, Sergii Domanskyi, Gianni Monaco, Verena Chung, Jineta Banerjee, Daniel Derrick, Alberto Valdeolivas, Haojun Li, Xu Xiao, Shun Wang, Frank Zheng, Wenxian Yang, Carlos A. Catania, Benjamin J. Lang, Thomas J. Bertus, Carlo Piermarocchi, Francesca P. Caruso, Michele Ceccarelli, Thomas Yu, Xindi Guo, Julie Bletz, John Coller, Holden Maecker, Caroline Duault, Vida Shokoohi, Shailja Patel, Joanna E. Liliental, Stockard Simon, Tumor Deconvolution DREAM Challenge consortium, Julio Saez-Rodriguez, Laura M. Heiser, Justin Guinney, Andrew J. Gentles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract We evaluate deconvolution methods, which infer levels of immune infiltration from bulk expression of tumor samples, through a community-wide DREAM Challenge. We assess six published and 22 community-contributed methods using in vitro and in
Externí odkaz:
https://doaj.org/article/fbdd2912b0694dcb86f190414734e1ac
Autor:
Caroline Holm Nørgaard, Lasse Hjort Jakobsen, Andrew J Gentles, Karen Dybkær, Tarec Christoffer El-Galaly, Julie Støve Bødker, Alexander Schmitz, Preben Johansen, Tobias Herold, Karsten Spiekermann, Jennifer R Brown, Josephine L Klitgaard, Hans Erik Johnsen, Martin Bøgsted
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193249 (2018)
Diagnostic and prognostic evaluation of chronic lymphocytic leukemia (CLL) involves blood cell counts, immunophenotyping, IgVH mutation status, and cytogenetic analyses. We generated B-cell associated gene-signatures (BAGS) based on six naturally occ
Externí odkaz:
https://doaj.org/article/54d6f02da4e545279292e8d9f730b34d
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 5, p e1004888 (2016)
We present a computational framework, called DISCERN (DIfferential SparsE Regulatory Network), to identify informative topological changes in gene-regulator dependence networks inferred on the basis of mRNA expression datasets within distinct biologi
Externí odkaz:
https://doaj.org/article/cb43c7c70f4c41fe8db0c3157da9debf
Autor:
Kevin Brennan, Almudena Espín-Pérez, Serena Chang, Nikita Bedi, Saumyaa Saumyaa, June Ho Shin, Sylvia K. Plevritis, Olivier Gevaert, John B. Sunwoo, Andrew J. Gentles
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-26 (2023)
Abstract Background The prognosis for patients with head and neck cancer (HNC) is poor and has improved little in recent decades, partially due to lack of therapeutic options. To identify effective therapeutic targets, we sought to identify molecular
Externí odkaz:
https://doaj.org/article/64cfbc02ed7142e4ba40972bf22f174f
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 4, p e1001123 (2011)
In biological systems that undergo processes such as differentiation, a clear concept of progression exists. We present a novel computational approach, called Sample Progression Discovery (SPD), to discover patterns of biological progression underlyi
Externí odkaz:
https://doaj.org/article/032c5863cac7400eb86d6845440c0ef3
Autor:
Almudena Espín-Pérez, Kevin Brennan, Asiri Saumya Ediriwickrema, Olivier Gevaert, Izidore S. Lossos, Andrew J. Gentles
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-9 (2022)
Abstract Lack of accurate methods for early lymphoma detection limits the ability to cure patients. Since patients with Non-Hodgkin lymphomas (NHL) who present with advanced disease have worse outcomes, accurate and sensitive methods for early detect
Externí odkaz:
https://doaj.org/article/ca0ac65f02104d1ba4809fa7abf17715
Autor:
Sandra Steyaert, Marija Pizurica, Divya Nagaraj, Priya Khandelwal, Tina Hernandez-Boussard, Andrew J. Gentles, Olivier Gevaert
Publikováno v:
Nature Machine Intelligence. 5:351-362
Autor:
Victoria G. Hernandez, Kendra J. Lechtenberg, Todd C. Peterson, Li Zhu, Tawaun A. Lucas, Karen P. Bradshaw, Justice O. Owah, Alanna I. Dorsey, Andrew J. Gentles, Marion S. Buckwalter
Publikováno v:
Glia.