Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Andrew J Fleetwood"'
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 12, Pp n/a-n/a (2020)
Abstract Macrophages are the first immune cells in the developing embryo and have a central role in organ development, homeostasis, immunity and repair. Over the last century, our understanding of these cells has evolved from being thought of as simp
Externí odkaz:
https://doaj.org/article/74f9aa12b7d44458a681fac9c613a3e2
Autor:
Tanya J. Lupancu, Kevin M.C. Lee, Mahtab Eivazitork, Cecil Hor, Andrew J. Fleetwood, Andrew D. Cook, Moshe Olshansky, Stephen J. Turner, Richard de Steiger, Keith Lim, John A. Hamilton, Adrian A. Achuthan
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108079- (2023)
Summary: Glucocorticoids (GCs) are potent anti-inflammatory agents and are broadly used in treating rheumatoid arthritis (RA) patients, albeit with adverse side effects associated with long-term usage. The negative consequences of GC therapy provide
Externí odkaz:
https://doaj.org/article/5677e94626014801a13fe86a32d5bf63
Autor:
Kevin M.-C. Lee, Zihao Zhang, Adrian Achuthan, Andrew J. Fleetwood, Julia E. Smith, John A. Hamilton, Andrew D. Cook
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-13 (2020)
Abstract Background The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lymphocyte-independent,
Externí odkaz:
https://doaj.org/article/b65df65eecae4eba8f05e807f9807c7a
Autor:
Man K. S. Lee, Annas Al-Sharea, Waled A. Shihata, Camilla Bertuzzo Veiga, Olivia D. Cooney, Andrew J. Fleetwood, Michelle C. Flynn, Ellen Claeson, Clovis S. Palmer, Graeme I. Lancaster, Darren C. Henstridge, John A. Hamilton, Andrew J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Monocytes in humans consist of 3 subsets; CD14+CD16− (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation. During acute inflammation CD14+CD16− monocytes are sig
Externí odkaz:
https://doaj.org/article/877fdbb79e87480fa17aaf1845695887
Autor:
Andrew J. Fleetwood, Man K.S. Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M. O'Brien-Simpson, Andrew D. Cook, Andrew J. Murphy, Stuart G. Dashper, Eric C. Reynolds, John A. Hamilton
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Porphyromonas gingivalis is one of the bacterial species most closely associated with periodontitis and can shed large numbers of outer membrane vesicles (OMVs), which are increasingly thought to play a significant role in bacterial virulence and pat
Externí odkaz:
https://doaj.org/article/facd0ad2ceeb44f3a8393eeeead9610a
Autor:
Kevin M.-C. Lee, Christian Ellson, Andrew D. Cook, Maria Feeney, Adrian Achuthan, Andrew J. Fleetwood, John A. Hamilton, Louise K. Modis, Julia Smith, Andrew G. Jarnicki, Gary P. Anderson
Publikováno v:
The Journal of Immunology. 205:213-222
It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated in the control of inflammatory pain, as well as arthritic pain and disease. We explore, in this study and in various i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda9aa4bf1d3f471aabfa698c02b910d
https://doi.org/10.4049/jimmunol.2000315
https://doi.org/10.4049/jimmunol.2000315
Autor:
Kevin M.-C. Lee, Adrian Achuthan, Andrew J. Fleetwood, Vidya Mangala Prasad, John A. Hamilton, Andrew D. Cook
Publikováno v:
Osteoarthritis and Cartilage. 28:486-491
Summary Objectives Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given the clinical data indicating that granulocyte macrophage-colony stimulating factor (GM-CSF) may be a therapeutic ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd25f9d259aaebcedb30b0ce7d1364d
https://doi.org/10.1016/j.joca.2020.01.012
https://doi.org/10.1016/j.joca.2020.01.012
Autor:
Kevin Ming-Chin Lee, Adrian A. Achuthan, David P. De Souza, Tanya J. Lupancu, Katrina J. Binger, Man K.S. Lee, Yangsong Xu, Malcolm J. McConville, Nicole A. de Weerd, Dragana Dragoljevic, Paul J. Hertzog, Andrew J. Murphy, John A. Hamilton, Andrew J. Fleetwood
Metabolic adaptations can directly influence the scope and scale of macrophage activation and polarization. Here we explore the impact of type I interferon (IFNβ) on macrophage metabolism and its broader impact on cytokine signaling pathways. We fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9087ccee1e2e9c30ad56e336e3fe05ce
Autor:
Larisa Dubrovsky, Beda Brichacek, N.M. Prashant, Tatiana Pushkarsky, Nigora Mukhamedova, Andrew J. Fleetwood, Yangsong Xu, Dragana Dragoljevic, Michael Fitzgerald, Anelia Horvath, Andrew J. Murphy, Dmitri Sviridov, Michael I. Bukrinsky
Publikováno v:
Cell Reports. 41:111674
A possible explanation for chronic inflammation in HIV-infected individuals treated with anti-retroviral therapy is hyperreactivity of myeloid cells due to a phenomenon called "trained immunity." Here, we demonstrate that human monocyte-derived macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0cd7070027eaf4b10ff282f59ab651
https://doi.org/10.1016/j.celrep.2022.111674
https://doi.org/10.1016/j.celrep.2022.111674
Autor:
David P De Souza, Malcolm J. McConville, Andrew D. Cook, Dedreia Tull, Adrian Achuthan, Ming-Chin Lee, Andrew J. Murphy, Sophia Davidson, Andrew J. Fleetwood, John A. Hamilton, Katrina J. Binger, Man K.S. Lee
Publikováno v:
Journal of Clinical Investigation. 129:4239-4244
Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate. We have identified that endogenous type I IFN controls the cellular citrate/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb30a326390c43e88a61dfb614c1c51c
https://doi.org/10.1172/jci127597
https://doi.org/10.1172/jci127597