Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Andrew J Ewald"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012195 (2024)
Therapeutic interventions are designed to perturb the function of a biological system. However, there are many types of proteins that cannot be targeted with conventional small molecule drugs. Accordingly, many identified gene-regulatory drivers and
Externí odkaz:
https://doaj.org/article/02ea3ba2e69f4ad4996c9faec1975b45
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007464 (2020)
For women with access to healthcare and early detection, breast cancer deaths are caused primarily by metastasis rather than growth of the primary tumor. Metastasis has been difficult to study because it happens deep in the body, occurs over years, a
Externí odkaz:
https://doaj.org/article/12dd0af4abf94080b7a0990fad6da970
Autor:
Helen R. Clark, Connor McKenney, Nathan M. Livingston, Ariel Gershman, Seema Sajjan, Isaac S. Chan, Andrew J. Ewald, Winston Timp, Bin Wu, Abhyudai Singh, Sergi Regot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Fine tuning the immune response in line with the degree of threat is central to recognition of a pathogen versus commensal bacteria. Here the authors implicate a digital all-or-nothing cell response in control of the tissue level immune response.
Externí odkaz:
https://doaj.org/article/c941a781c5064d999cddc94eed6d7777
Autor:
Elodie Henriet, Hildur Knutsdottir, Eloise M. Grasset, Matthew Dunworth, Meagan Haynes, Joel S. Bader, Andrew J. Ewald
Publikováno v:
Oncogene. 42:737-747
Autor:
Geonhui Lee, Claudia Wong, Anna Cho, Junior J. West, Ashleigh J. Crawford, Gabriella C. Russo, Bishwa Ranjan Si, Jungwoo Kim, Lauren Hoffner, Cholsoon Jang, Moonjung Jung, Robert D. Leone, Konstantinos Konstantopoulos, Andrew J. Ewald, Denis Wirtz, Sangmoo Jeong
Publikováno v:
bioRxiv
The loss of E-cadherin (E-cad), an epithelial cell adhesion molecule, has been implicated in the epithelial-mesenchymal transition (EMT), promoting invasion and migration of cancer cells and, consequently, metastasis. However, recent studies have dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fc88719f8686b1892099ccf3116d15
https://europepmc.org/articles/PMC10245808/
https://europepmc.org/articles/PMC10245808/
Autor:
Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L. Huso, Andrew J. Ewald, Linda M. S. Resar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth
Externí odkaz:
https://doaj.org/article/5e3c00d6fe3d4dd9b4ee8a6610a4fe99
Autor:
Yea Ji Jeong, Hildur Knutsdottir, Fatemeh Shojaeian, Michael G. Lerner, Maria F. Wissler, Elodie Henriet, Tammy Ng, Shalini Datta, Bernat Navarro-Serer, Peter Chianchiano, Benedict Kinny-Köster, Jacquelyn W. Zimmerman, Genevieve Stein-O’Brien, Matthias M. Gaida, James R. Eshleman, Ming-Tseh Lin, Elana J. Fertig, Andrew J. Ewald, Joel S. Bader, Laura D. Wood
Publikováno v:
Journal of Clinical Investigation. 133
Autor:
Andrew J. Ewald, Gareth J. Thomas, Orit Katarina Sirka, Elodie Henriet, Christopher J. Hanley
Supplementary Materials and Methods. Figure S1. Weighted gene correlation network analysis of RNA-Sequencing from human invasive ductal breast cancer primary tumor samples.Figure S2: Physical interaction between stromal cells and invasive organoids.F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0319f79db58113c12ed2728f890bb6
https://doi.org/10.1158/1541-7786.22525823
https://doi.org/10.1158/1541-7786.22525823
Autor:
Timothy F. Burns, Phuoc T. Tran, Charles M. Rudin, Yoon-Jae Cho, Andrew J. Ewald, Johnathan A. Engh, Ashwin Somasundaram, Katriana Nugent, Sarah N. Chatley, Eric H.-B. Huang, Myriam A. Attar, Hailun Wang, Suman Chatterjee, Susheel K. Khetarpal, Neil M. Neumann, Lucia Mazzacurati, Jessica Cades, Zachary A. Yochum
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfa1b6007ee5e3f0d85bba1531cda94
https://doi.org/10.1158/1541-7786.22516038.v1
https://doi.org/10.1158/1541-7786.22516038.v1
Autor:
Andrew J. Ewald, Gareth J. Thomas, Orit Katarina Sirka, Elodie Henriet, Christopher J. Hanley
Collective invasion can be led by breast cancer cells expressing basal epithelial markers, typified by keratin-14 (KRT14). We analyzed gene expression data from The Cancer Genome Atlas and demonstrated a significant correlation between a KRT14+ invas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d7f15cdf23b158c4bb7224a9382bb2
https://doi.org/10.1158/1541-7786.c.6544919
https://doi.org/10.1158/1541-7786.c.6544919