Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Andrew J Doherty"'
Autor:
Filip A. Konopacki, Nadia Jaafari, Daniel L. Rocca, Andrew J Doherty, Inmaculada M. González-González, Jeremy M. Henley, Kevin A. Wilkinson
Publikováno v:
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1:31-44
Kainate receptors (KARs) are ligand-gated ion channels that can regulate neuronal network activity and are involved in processes ranging from neuronal development and differentiation to neurodegeneration and neuronal cell death. They are tetrameric a
Autor:
David E. Jane, Graham L. Collingridge, Kwangwook Cho, Sheila L. Dargan, Mascia Amici, Jihoon Jo, Andrew J Doherty
Publikováno v:
Biochemical Society Transactions. 37:1359-1363
Calcium entry plays a major role in the induction of several forms of synaptic plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can determine the type of synaptic plasticity induced, e.g
Autor:
Ceri H. Davies, Andrew J Doherty, Andrew D. Randall, Sébastien J. Thuault, Sonia Piccinin, Zuner A. Bortolotto, Jon T. Brown, Graham L. Collingridge
Publikováno v:
Neuropharmacology. 55:459-463
It is well established that activation of group I metabotropic glutamate receptors (mGluRs) produces long-lasting alterations in synaptic efficacy. We now demonstrate that activation of mGluRs can also induce long-term alterations in synchronised net
Publikováno v:
European Journal of Pharmacology. 585:50-59
In the present article we show how studying synaptic mechanisms in hippocampal slice preparations provides information that may be useful in, firstly, the understanding of the aetiology of Alzheimer's disease and, secondly, in the development of nove
Autor:
Changiz Taghibiglou, Clarrisa A. Bradley, Zuner A. Bortolotto, Andrew J Doherty, Stéphane Peineau, Yu Tian Wang, Graham L. Collingridge
Publikováno v:
British Journal of Pharmacology. 153:S428-S437
Glycogen synthase kinase-3 (GSK-3), an important component of the glycogen metabolism pathway, is highly expressed in the CNS. It has been implicated in major neurological disorders including Alzheimer's disease, schizophrenia and bipolar disorders.
Publikováno v:
Molecular Brain
Endoplasmic reticulum (ER) is motile within dendritic spines, but the mechanisms underlying its regulation are poorly understood. To address this issue, we have simultaneously imaged morphology and ER content of dendritic spines in cultured dissociat
Autor:
A.E. Kingston, Mary J. Palmer, AC Hargreaves, D D Schoepp, Andrew J Doherty, P. L. Ornstein, David Lodge, Graham L. Collingridge, Zuner A. Bortolotto
Publikováno v:
British Journal of Pharmacology. 131:239-244
1. We have investigated the pharmacological properties of LY344545, a structurally related epimer of the broad spectrum competitive metabotropic glutamate receptor antagonist, LY341495. We have found that LY344545 also antagonizes competitively nearl
Publikováno v:
British Journal of Pharmacology. 126:205-210
We have investigated the antagonist properties of 6 α-substituted phenylglycine analogues based on the structure of 4-carboxyphenylglycine (4-CPG) for group I metabotropic glutamate receptors (mGlu1α and mGlu5a) permanently expressed in CHO cells.
Autor:
Paul L. Ornstein, Stephen M. Fitzjohn, Mary J. Palmer, A.E. Kingston, Andrew J Doherty, D D Schoepp, David Lodge, Graham L. Collingridge, Zuner A. Bortolotto
Publikováno v:
Neuropharmacology. 37:1445-1458
Understanding the roles of metabotropic glutamate (mGlu) receptors has been severely hampered by the lack of potent antagonists. LY341495 (2S-2-amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-y l)propanoic acid) has been shown to block group II
Publikováno v:
Neuron. 52:222-224
What controls the number of AMPA receptors at excitatory synapses? MAGUKs are known to play a critical role in this process, but which ones are involved and when has been contentious. In this issue of Neuron , Elias et al. have elucidated the roles o