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pro vyhledávání: '"Andrew J, Wicks"'
Autor:
Ilirjana Bajrami, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Andrew J. Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated tha
Externí odkaz:
https://doaj.org/article/d5f5e8c9681d4c1cb2934f06ed9a1386
Autor:
Andrew J. Wicks, Dragomir B. Krastev, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Open Biology, Vol 12, Iss 7 (2022)
PARP inhibitors (PARPi) have been demonstrated to exhibit profound anti-tumour activity in individuals whose cancers have a defect in the homologous recombination DNA repair pathway. Here, we describe the current consensus as to how PARPi work and ho
Externí odkaz:
https://doaj.org/article/4b60bfc0f8324ff39565168634c77471
Autor:
Andrew Tutt, Syed Haider, John Alexander, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Christopher J. Lord, Rachel Brough, Andrew J. Wicks, Stephen J. Pettitt, Ilirjana Bajrami
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
PARP enzymes utilise NAD+ as a co-substrate for their enzymatic activity. Inhibition of PARP1 is synthetic lethal with defects in either BRCA1 or BRCA2. In order to assess whether other genes implicated in NAD+ metabolism were synthetic lethal with B
Publikováno v:
Cancer research. 81(22)
Small molecule inhibitors of polyADP-ribose polymerase (PARP) are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA single strand breaks. However, the mechanism of action of PARP inhibitors with regard to the
Autor:
Kristijan Ramadan, Andrew J. Wicks, Yilun Sun, Andrew Tutt, Eleanor Knight, Christopher J. Lord, Mercedes Pardo Calvo, Dragomir B. Krastev, Jyoti S. Choudhary, Yves Pommier, Shudong Li, Tanaji T. Talele, Jiri Bartek, Lu Yu, Stephen J. Pettitt, Daniel Weekes, Luned M. Badder, Rebecca Marlow
Summary paragraphPoly-(ADP-ribose) polymerase inhibitors (PARPi) elicit anti-tumour activity in homologous recombination defective cancers by promoting cytotoxic, chromatin-bound, “trapped” PARP1. How cells process trapped PARP1 remains unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40976d3695cd0608b753e0e491a87e4a
https://doi.org/10.1101/2021.07.16.452473
https://doi.org/10.1101/2021.07.16.452473
Autor:
Dragomir B, Krastev, Shudong, Li, Yilun, Sun, Andrew J, Wicks, Gwendoline, Hoslett, Daniel, Weekes, Luned M, Badder, Eleanor G, Knight, Rebecca, Marlow, Mercedes Calvo, Pardo, Lu, Yu, Tanaji T, Talele, Jiri, Bartek, Jyoti S, Choudhary, Yves, Pommier, Stephen J, Pettitt, Andrew N J, Tutt, Kristijan, Ramadan, Christopher J, Lord
Publikováno v:
Nature cell biology. 24(1)
Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. How cells process trapped PARP1 remains unclear. Using wild-type and a trapping-defi
Autor:
Marie-France Langelier, Ben E. Black, Levani Zandarashvili, Jamin D. Steffen, Andrew J. Wicks, John M. Pascal, Uday Kiran Velagapudi, Tanaji T. Talele, Stephen J. Pettitt, Ramya Billur, Christopher J. Lord, Mark A. Hancock, Zain M. Hannan, Dragomir B. Krastev
Publikováno v:
Science
DNA death grip Poly(ADP-ribose) polymerase–1 (PARP-1) binds to DNA breaks and recruits DNA repair components. Cancer-killing PARP-1 inhibitor (PARPi) compounds all block the same catalytic site but exhibit vastly different efficacy. Zandarashvili e