Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Andrew J, Todd"'
Autor:
Olivia C. Davis, Allen C. Dickie, Marami B. Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input w
Externí odkaz:
https://doaj.org/article/e1e8b47c69cd415985186a348e491925
Autor:
Raphaëlle Quillet, Maria Gutierrez-Mecinas, Erika Polgár, Allen C. Dickie, Kieran A. Boyle, Masahiko Watanabe, Andrew J. Todd
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The superficial dorsal horn (SDH) of the spinal cord contains a diverse array of neurons. The vast majority of these are interneurons, most of which are glutamatergic. These can be assigned to several populations, one of which is defined by expressio
Externí odkaz:
https://doaj.org/article/4d0a7cd44dd146b09de0df51daf423a2
Autor:
Tyler S. Nelson, Heather N. Allen, Paramita Basu, Pranav Prasoon, Eileen Nguyen, Cynthia M. Arokiaraj, Diogo F.S. Santos, Rebecca P. Seal, Sarah E. Ross, Andrew J. Todd, Bradley K. Taylor
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Neuropeptide Y targets the Y1 receptor (Y1) in the spinal dorsal horn (DH) to produce endogenous and exogenous analgesia. DH interneurons that express Y1 (Y1-INs; encoded by Npy1r) are necessary and sufficient for neuropathic hypersensitivity after p
Externí odkaz:
https://doaj.org/article/12aac04266fb4e319cbf254fd2f81a36
Autor:
Raphaëlle Quillet, Allen C. Dickie, Erika Polgár, Maria Gutierrez-Mecinas, Andrew M. Bell, Luca Goffin, Masahiko Watanabe, Andrew J. Todd
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Excitatory interneurons in the superficial dorsal horn (SDH) are heterogeneous, and include a class known as vertical cells, which convey information to lamina I projection neurons. We recently used pro-NPFF antibody to reveal a discrete pop
Externí odkaz:
https://doaj.org/article/49b37dbfaf174974afe847d1c5b21974
Autor:
Kieran A Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C Dickie, Andrew H Cooper, Andrew M Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I Hughes, Gregory A Weir, John S Riddell, Andrew J Todd
Publikováno v:
eLife, Vol 12 (2023)
Somatosensory information is processed by a complex network of interneurons in the spinal dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y (NPY), either permanently or during development, suppress mechanical
Externí odkaz:
https://doaj.org/article/0aaa87dba12840cf9be5bf7916875d41
Autor:
Remi Ronzano, Sophie Skarlatou, Bianca K Barriga, B Anne Bannatyne, Gardave Singh Bhumbra, Joshua D Foster, Jeffrey D Moore, Camille Lancelin, Amanda M Pocratsky, Mustafa Görkem Özyurt, Calvin Chad Smith, Andrew J Todd, David J Maxwell, Andrew J Murray, Samuel L Pfaff, Robert M Brownstone, Niccolò Zampieri, Marco Beato
Publikováno v:
eLife, Vol 11 (2022)
Elaborate behaviours are produced by tightly controlled flexor-extensor motor neuron activation patterns. Motor neurons are regulated by a network of interneurons within the spinal cord, but the computational processes involved in motor control are n
Externí odkaz:
https://doaj.org/article/37ef81ba8f534a69a63ce04d90cb929f
Autor:
Wafa A. A. Alsulaiman, Raphaelle Quillet, Andrew M. Bell, Allen C. Dickie, Erika Polgár, Kieran A. Boyle, Masahiko Watanabe, R. Brian Roome, Artur Kania, Andrew J. Todd, Maria Gutierrez-Mecinas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract A recently developed Phox2a::Cre mouse line has been shown to capture anterolateral system (ALS) projection neurons. Here, we used this line to test whether Phox2a-positive cells represent a distinct subpopulation among lamina I ALS neurons.
Externí odkaz:
https://doaj.org/article/45445ef9894d49f187740e8e7d79332d
Autor:
Andrew J. Todd
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Externí odkaz:
https://doaj.org/article/1775c07f011f4035850d492265e80006
Autor:
Maria, Gutierrez-Mecinas, Éva, Kókai, Erika, Polgár, Raphaëlle, Quillet, Heather F, Titterton, Greg A, Weir, Masahiko, Watanabe, Andrew J, Todd
Publikováno v:
Neuroscience. 510:60-71
Gastrin-releasing peptide (GRP) in the spinal dorsal horn acts on the GRP receptor, and this signalling mechanism has been strongly implicated in itch. However, the source of GRP in the dorsal horn is not fully understood. For example, the BAC transg
Autor:
Corinne El Khoueiry, Cristina Alba-Delgado, Myriam Antri, Maria Gutierrez-Mecinas, Andrew J. Todd, Alain Artola, Radhouane Dallel
Publikováno v:
Cells, Vol 11, Iss 8, p 1356 (2022)
Mechanical allodynia (pain to normally innocuous tactile stimuli) is a widespread symptom of inflammatory and neuropathic pain. Spinal or medullary dorsal horn (SDH or MDH) circuits mediating tactile sensation and pain need to interact in order to ev
Externí odkaz:
https://doaj.org/article/9af9cae2a5634251989ad7de05a50b48