Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Andrew J, Peacock"'
Autor:
Kathryn S. Wilson, Hanna Buist, Kornelija Suveizdyte, John T. Liles, Grant R. Budas, Colin Hughes, Margaret R. MacLean, Martin Johnson, Alistair C. Church, Andrew J. Peacock, David J. Welsh
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Pulmonary arterial hypertension, group 1 of the pulmonary hypertension disease family, involves pulmonary vascular remodelling, right ventricular dysfunction and cardiac failure. Oxidative stress, through activation of mitogen-activated protein kinas
Externí odkaz:
https://doaj.org/article/6525394d6a864924aa813898fecdb00f
Autor:
Andrew J. Peacock, Yi Ling, Martin K. Johnson, David G. Kiely, Robin Condliffe, Charlie A. Elliot, J. Simon R. Gibbs, Luke S. Howard, Joanna Pepke-Zaba, Karen K.K. Sheares, Paul A. Corris, Andrew J. Fisher, James L. Lordan, Sean Gaine, J. Gerry Coghlan, S. John Wort, Michael A. Gatzoulis
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Patients classified as idiopathic pulmonary arterial hypertension (defined as Group 1 on European Respiratory Society (ERS)/European Cardiac Society (ESC) criteria) may have evidence of minor co-existing lung disease on thoracic computed tomography.
Externí odkaz:
https://doaj.org/article/706f765a1ce94cf38464ec652442ad0a
Autor:
Geeshath Jayasekera, Kathryn S. Wilson, Hanna Buist, Rosemary Woodward, Aysel Uckan, Colin Hughes, Margaret Nilsen, A Colin Church, Martin K. Johnson, Lindsay Gallagher, James Mullin, Mandy R. MacLean, William M. Holmes, Andrew J. Peacock, David J. Welsh
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Cardiac magnetic resonance-derived ventricular variables are predictive of mortality in pulmonary arterial hypertension. Rodent models which emphasize ventricular function, allowing serial monitoring, are needed to identify pathophysiological feature
Externí odkaz:
https://doaj.org/article/16df05497cb345c3b63ec397451bbf19
Autor:
Stefan Gräf, Matthias Haimel, Marta Bleda, Charaka Hadinnapola, Laura Southgate, Wei Li, Joshua Hodgson, Bin Liu, Richard M. Salmon, Mark Southwood, Rajiv D. Machado, Jennifer M. Martin, Carmen M. Treacy, Katherine Yates, Louise C. Daugherty, Olga Shamardina, Deborah Whitehorn, Simon Holden, Micheala Aldred, Harm J. Bogaard, Colin Church, Gerry Coghlan, Robin Condliffe, Paul A. Corris, Cesare Danesino, Mélanie Eyries, Henning Gall, Stefano Ghio, Hossein-Ardeschir Ghofrani, J. Simon R. Gibbs, Barbara Girerd, Arjan C. Houweling, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Robert V. MacKenzie Ross, Shahin Moledina, David Montani, Michael Newnham, Andrea Olschewski, Horst Olschewski, Andrew J. Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J. Rhodes, Laura Scelsi, Werner Seeger, Florent Soubrier, Dan F. Stein, Jay Suntharalingam, Emilia M. Swietlik, Mark R. Toshner, David A. van Heel, Anton Vonk Noordegraaf, Quinten Waisfisz, John Wharton, Stephen J. Wort, Willem H. Ouwehand, Nicole Soranzo, Allan Lawrie, Paul D. Upton, Martin R. Wilkins, Richard C. Trembath, Nicholas W. Morrell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Pulmonary arterial hypertension (PAH) is a rare lung disorder characterised by narrowing and obliteration of small pulmonary arteries ultimately leading to right heart failure. Here, the authors sequence whole genomes of over 1000 PAH patients and id
Externí odkaz:
https://doaj.org/article/cb3171b4e79940aa9ab812b5a9ce621a
Autor:
Lauren Brash, MD, Gareth D. Barnes, MD, Melanie J. Brewis, MD, A. Colin Church, MD, Simon J. Gibbs, MD, Luke S.G.E. Howard, MD, Geeshath Jayasekera, MBChB, Martin K. Johnson, MD, Neil McGlinchey, MBChB, Joelle Onorato, PhD, Joanne Simpson, MD, Colin Stirrat, MD, Stephen Thomson, MBChB, Geoffrey Watson, MD, Martin R. Wilkins, MD, Carrie Xu, MS, David J. Welsh, PhD, David E. Newby, MD, Andrew J. Peacock, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 176-186 (2018)
Summary: Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of syst
Externí odkaz:
https://doaj.org/article/dabac17dc7ae4c07888b359d538839c4
Autor:
David G. Kiely, David L. Levin, Paul M. Hassoun, Dunbar Ivy, Pei-Ni Jone, Jumaa Bwika, Steven M. Kawut, Jim Lordan, Angela Lungu, Jeremy A. Mazurek, Shahin Moledina, Horst Olschewski, Andrew J. Peacock, G.D. Puri, Farbod N. Rahaghi, Michal Schafer, Mark Schiebler, Nicholas Screaton, Merryn Tawhai, Edwin J.R. van Beek, Anton Vonk-Noordegraaf, Rebecca Vandepool, Stephen J. Wort, Lan Zhao, Jim M. Wild, Jens Vogel-Claussen, Andrew J. Swift
Publikováno v:
Pulmonary Circulation, Vol 9 (2019)
Pulmonary hypertension (PH) is highly heterogeneous and despite treatment advances it remains a life-shortening condition. There have been significant advances in imaging technologies, but despite evidence of their potential clinical utility, practic
Externí odkaz:
https://doaj.org/article/07df8bbb28ba42c3be4075e16f90f3ba
Autor:
Andrew J. Peacock, Anton Vonk Noordegraaf, Nicolas Martin, Nazzareno Galiè, Adam Torbicki, J. Tim Marcus, David G. Kiely, Olga Moiseeva, Stephan Rosenkranz, Ahmed Tawakol, Emmanuelle Cottreel, Andrew J. Swift, Richard N. Channick
Publikováno v:
JACC: Cardiovascular Imaging. 15:240-253
Objectives The REPAIR (Right vEntricular remodeling in Pulmonary ArterIal hypeRtension) study evaluated the effect of macitentan on right ventricular (RV) and hemodynamic outcomes in patie...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ae1f8d20648a125abacec9aa427bbe
https://doi.org/10.1016/j.jcmg.2021.07.027
https://doi.org/10.1016/j.jcmg.2021.07.027
Autor:
Ekkehard Grünig, Andrew J. Peacock
Publikováno v:
European Respiratory Review, Vol 24, Iss 138, Pp 653-664 (2015)
Noninvasive imaging of the heart plays an important role in the diagnosis and management of pulmonary hypertension (PH), and several well-established techniques are available for assessing performance of the right ventricle, the key determinant of pa
Externí odkaz:
https://doaj.org/article/b6943eda02ad42f0a9e2008facf01918
Publikováno v:
Pulmonary Circulation, Vol 8 (2017)
Pulmonary hypertension (PH) is a progressive illness characterized by elevated pulmonary artery pressure; however, the main cause of mortality in PH patients is right ventricular (RV) failure. Historically, improving the hemodynamics of pulmonary cir
Externí odkaz:
https://doaj.org/article/34dbf1a9ff4d469db3aaa2dac448fda3
Publikováno v:
European Respiratory Review, Vol 26, Iss 143 (2017)
Pulmonary vascular and cardiac impairment is increasingly appreciated as a major adverse factor in the natural history of interstitial lung disease. This clinically orientated review focuses on the current concepts in the pathogenesis, pathophysiolog
Externí odkaz:
https://doaj.org/article/61fe918becb94c48ac5d0dd9d336ed83