Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis

Autor: Andrew J. Kwilasz, Madison A. Clements, Tracey A. Larson, Kevin M. Harris, Scott T. Litwiler, Brodie J. Woodall, Laurel S. Todd, Anouk E. W. Schrama, Eric H. Mitten, Steven F. Maier, Anne-Marie Van Dam, Kenner C. Rice, Linda R. Watkins

Publikováno v: Frontiers in Pain Research, Vol 3 (2022)

Up to 92% of patients suffering from multiple sclerosis (MS) experience pain, most without adequate treatment, and many report pain long before motor symptoms associated with MS diagnosis. In the most commonly studied rodent model of MS, experimental

Externí odkaz: https://doaj.org/article/f69561aa0381439c90004b4abc048684

Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats

Autor: Heather M. D'Angelo, Michael J. Lacagnina, Jiahe Li, Suzanne M. Green-Fulgham, Sabina Lorca, Michael E. Harland, Peter M. Grace, Linda R. Watkins, Renee A. Dreher, Steven F. Maier, Andrew J. Kwilasz, Jayson B. Ball

Animal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive. Given that exercise acutely increases formation of free radicals, triggering antioxidant c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f8113f4dedab82b30d67540f1f79e7c
https://doi.org/10.1101/2021.07.21.452532

T cell transgressions: Tales of T cell form and function in diverse disease states

Autor: Andrew J. Kwilasz, Madison A. Clements, Linda R. Watkins, Kevin M. Harris

Publikováno v: Int Rev Immunol

Insights into T cell form, function, and dysfunction are rapidly evolving. T cells have remarkably varied effector functions including protecting the host from infection, activating cells of the innate immune system, releasing cytokines and chemokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5bed8629dd66eb53bfe1c8b87c0680
https://europepmc.org/articles/PMC8752099/

Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone

Autor: Tracey A Larson, Eric H. Mitten, Madison A. Clements, Ruth M. Barrientos, Linda R. Watkins, Scott T. Litwiler, Kevin M. Harris, Andrew J. Kwilasz, Julissa Chante Duran-Malle, Kenner C. Rice, Xiaohui Wang, Anouk E.W. Schrama, Steven F. Maier, Laurel S. Todd, Anne Marie van Dam

Publikováno v: Kwilasz, A J, Todd, L S, Duran-Malle, J C, Schrama, A E W, Mitten, E H, Larson, T A, Clements, M A, Harris, K M, Litwiler, S T, Wang, X, Van Dam, A M, Maier, S F, Rice, K C, Watkins, L R & Barrientos, R M 2021, ' Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone ', Behavioural Brain Research, vol. 396, 112896 . https://doi.org/10.1016/j.bbr.2020.112896
Behavioural Brain Research, 396:112896. Elsevier
Behav Brain Res

Multiple sclerosis (MS) is associated with burdensome memory impairments and preclinical literature suggests that these impairments are linked to neuroinflammation. Previously, we have shown that toll-like receptor 4 (TLR4) antagonists, such as (+)-n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b442f713bdf03ab4a15e0e15c0ad535d
https://research.vumc.nl/en/publications/13e8b0df-6825-424a-98ba-fda993cbfc64

Effects of opioid receptor ligands in rats trained to discriminate 22 from 2 hours of food deprivation suggest a lack of opioid involvement in eating for hunger

Autor: Chloe Brunton, Regina M. Carroll, Andrew J. Kwilasz, Mitchell A. Head, Pawel K. Olszewski, Thomas W. Hahn, David C. Jewett, Anica Klockars, Allen S. Levine, Jason M. Wiebelhaus, Martha K. Grace, Rachel L. Tham, Travis R. Smith, Eric E. Ewan

Publikováno v: Behavioural brain research. 380

It is well accepted that opioids promote feeding for reward. Some studies suggest a potential involvement in hunger-driven intake, but they suffer from the scarcity of methodologies differentiating between factors that intersect eating for pleasure v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d268b3b1315b8468dea5364492a574
https://pubmed.ncbi.nlm.nih.gov/31743731