Výsledky vyhledávání - "Andrew J, Kassick"

Akademický článek

Evaluating the rate of reversal of fentanyl-induced respiratory depression using a novel long-acting naloxone nanoparticle, cNLX-NP

Autor: Saadyah E. Averick, Andrew J. Kassick, Daihyun Song, Borui Zhang, Jennifer Vigliaturo, Diego Luengas, Pedro Silva-Ortiz, Marco Pravetoni, Michael D. Raleigh

Publikováno v: Frontiers in Psychiatry, Vol 15 (2024)

IntroductionFentanyl and fentanyl analogs (F/FA) have become increasingly common adulterants in counterfeit prescription pills and illicit street drug mixtures due to their ease of synthesis and exceedingly high potency. The ongoing epidemic of fatal

Externí odkaz: https://doaj.org/article/86ed8107bf8a4408b5e7152bbfc265b8

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Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats

Autor: Bethany Crouse, Mariah M. Wu, Valeria Gradinati, Andrew J. Kassick, Daihyun Song, Rajwana Jahan, Saadyah Averick, Scott Runyon, Sandra D. Comer, Marco Pravetoni

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] Drug-related fatal overdoses have significantly increased in the past decade due to the widespread availability of illicit fentanyl and other potent synthetic opioids such as carfentanil. Deliberate or accidental consumption or expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ca0f7202452fc21bffc599fe5d5441
https://doi.org/10.1021/acsptsci.1c00260

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Design, synthesis, and biological evaluation of C6-difluoromethylenated epoxymorphinan Mu opioid receptor antagonists

Autor: Andrew J. Kassick, Nestor D. Tomycz, Michael G. Feasel, Benedict J. Kolber, Saadyah Averick, Anny C. Treat

Publikováno v: RSC Medicinal Chemistry. 13:175-182

The recent widespread abuse of high potency synthetic opioids, such as fentanyl, presents a serious threat to individuals affected by substance use disorder. Synthetic opioids generally exhibit prolonged in vivo circulatory half-lives that can outlas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6afd5fbb615358948992073339fbdc73
https://doi.org/10.1039/d1md00285f

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Covalently Loaded Naloxone Nanoparticles as a Long-Acting Medical Countermeasure to Opioid Poisoning

Autor: Michael D. Raleigh, Toby L. Nelson, Saadyah Averick, Mohammad Ebqa'Ai, Diego Luengas, Mariah Wu, Nestor D. Tomycz, Andrew J. Kassick, Marco Pravetoni, L. P. Tharika Nirmani

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] The mu opioid receptor antagonist naloxone has been a vital, long-standing countermeasure in the ongoing battle against opioid use disorders (OUD) and toxicity. However, due to its distinctive short elimination half-life, naloxone h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcc25b1d4f9c95bcd0f86777c0fd722
https://doi.org/10.1021/acsptsci.1c00168

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SuFEx-based strategies for the preparation of functional particles and cation exchange resins

Autor: Jason Locklin, Saadyah Averick, Robert T. Mathers, Andrew J. Kassick, Marina Kovaliov, Li Chen

Publikováno v: Chemical Communications. 55:3891-3894

A predictable and reproducible number of sulfuric acid sites have been achieved for cation exchange resins by employing a mild SuFEx-based reagent system to effect the hydrolysis of fluorosulfonated polymer beads. The resultant poly(hydrogen sulfate)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2bb1670238c8e6fa1c4fa280af40bf
https://doi.org/10.1039/c9cc00036d

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Slow-sustained delivery of naloxone reduces typical naloxone-induced precipitated opioid withdrawal effects in male morphine-dependent mice

Autor: Lakeisha A. Lewter, Saadyah Averick, Anny C. Treat, Marisa C. Johnson, Andrew J. Kassick, Benedict J. Kolber

Publikováno v: J Neurosci Res

Thousands of individuals die each year from opioid-related overdoses. While naloxone (Narcan(®)) is currently the most widely employed treatment to reverse opioid toxicity, high or repeated doses of this antidote often lead to precipitated opioid wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0784f73d1d9c10297d5a513ede6269
https://pubmed.ncbi.nlm.nih.gov/32772457

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Osteoconductive Enhancement of Polyether Ether Ketone: A Mild Covalent Surface Modification Approach

Autor: Michael Oh, Phil G. Campbell, Eric Gottlieb, Francis Cartieri, Boyle C. Cheng, Mark Carl Miller, Alexander Kharlamov, Chen Xu, Saadyah Averick, Yushuan Peng, Gordon Mao, Tomasz Kowalewski, Saigopalakrishna S. Yerneni, Andrew J. Kassick

Publikováno v: ACS Applied Bio Materials. 1:1047-1055

Polyether ether ketone (PEEK, 1) is an important material for the fabrication of implants employed in spinal fusion surgery. Although its radiolucency and favorable elastic modulus have made PEEK an attractive choice for interbody fusion devices, its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a437147c488732c661223de7e6552f
https://doi.org/10.1021/acsabm.8b00274

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