Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Andrew J, Kassianos"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Chronic kidney disease (CKD) is the progressive loss of kidney function/structure over a period of at least 3 months. It is characterised histologically by the triad of cell loss, inflammation and fibrosis. This literature review focuses on the forms
Externí odkaz:
https://doaj.org/article/bff684eed2e6487aa77f45cc5c5604fa
Autor:
Xiangju Wang, Chang Seong Kim, Benjamin C. Adams, Ray Wilkinson, Michelle M. Hill, Alok K. Shah, Ahmed Mohamed, Mriga Dutt, Monica S.Y. Ng, Jacobus P.J. Ungerer, Helen G. Healy, Andrew J. Kassianos
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103042- (2024)
Hypoxia is the key pathobiological trigger of tubular oxidative stress and cell death that drives the transition of acute kidney injury (AKI) to chronic kidney disease (CKD). The mitochondrial-rich proximal tubular epithelial cells (PTEC) are uniquel
Externí odkaz:
https://doaj.org/article/898c2efbe8a34d2eb160c44c13860921
Autor:
Arti M. Raghubar, Nicholas A. Matigian, Joanna Crawford, Leo Francis, Robert Ellis, Helen G. Healy, Andrew J. Kassianos, Monica S. Y. Ng, Matthew J. Roberts, Simon Wood, Andrew J. Mallett
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Perioperative immune checkpoint inhibitor (ICI) trials for intermediate high-risk clear cell renal cell carcinoma (ccRCC) have failed to consistently demonstrate improved patient outcomes. These unsuccessful ICI trials suggest that the tumou
Externí odkaz:
https://doaj.org/article/61bde8200489472a9c91dfe298700bf9
Autor:
Kurt T. K. Giuliani, Anca Grivei, Purba Nag, Xiangju Wang, Melissa Rist, Katrina Kildey, Becker Law, Monica S. Ng, Ray Wilkinson, Jacobus Ungerer, Josephine M. Forbes, Helen Healy, Andrew J. Kassianos
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-13 (2022)
Abstract Inflammasomes are multiprotein platforms responsible for the release of pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Mouse studies have identified inflammasome activation within dendritic cells (DC) as pivotal for driving tubul
Externí odkaz:
https://doaj.org/article/3f6627c645814f06a5a8676f3b366cb9
Autor:
Muhammad Ali Khan, Purba Nag, Anca Grivei, Kurt T. K. Giuliani, Xiangju Wang, Vishal Diwan, Wendy Hoy, Helen Healy, Glenda Gobe, Andrew J. Kassianos
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-12 (2022)
Externí odkaz:
https://doaj.org/article/f82ab151dced496797be4d83e6b73a17
Autor:
Arti M. Raghubar, Matthew J. Roberts, Simon Wood, Helen G. Healy, Andrew J. Kassianos, Andrew J. Mallett
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Clear cell renal cell carcinoma (ccRCC) is globally the most prevalent renal cancer. The cells of origin in ccRCC have been identified as proximal tubular epithelial cells (PTEC); however, the transcriptomic pathways resulting in the transition from
Externí odkaz:
https://doaj.org/article/52c3a8cf7fc2497986ed90e07eca1b04
Autor:
Arti M. Raghubar, Duy T. Pham, Xiao Tan, Laura F. Grice, Joanna Crawford, Pui Yeng Lam, Stacey B. Andersen, Sohye Yoon, Siok Min Teoh, Nicholas A. Matigian, Anne Stewart, Leo Francis, Monica S. Y. Ng, Helen G. Healy, Alexander N. Combes, Andrew J. Kassianos, Quan Nguyen, Andrew J. Mallett
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Available transcriptomes of the mammalian kidney provide limited information on the spatial interplay between different functional nephron structures due to the required dissociation of tissue with traditional transcriptome-based methodologies. A dee
Externí odkaz:
https://doaj.org/article/f9f48ceb22244753811383cd23084a84
Autor:
Muhammad Ali Khan MPharm, Andrew J Kassianos PhD, Wendy E Hoy MD, AHM Khurshid Alam PhD, Helen G Healy MD, Glenda C Gobe PhD
Publikováno v:
Journal of Evidence-Based Integrative Medicine, Vol 27 (2022)
Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current
Externí odkaz:
https://doaj.org/article/8587d04c760d41e09036ccbf4d5747d4
Autor:
Xiangju Wang, Ray Wilkinson, Katrina Kildey, Jacobus P. J. Ungerer, Michelle M. Hill, Alok K. Shah, Ahmed Mohamed, Mriga Dutt, Jeffrey Molendijk, Helen Healy, Andrew J. Kassianos
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)
Abstract Proximal tubular epithelial cells (PTEC) are central players in inflammatory kidney diseases. However, the complex signalling mechanism/s via which polarized PTEC mediate disease progression are poorly understood. Small extracellular vesicle
Externí odkaz:
https://doaj.org/article/362686f92a7b4321ab77cd8a5c3ee295
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Systemic lupus erythematosus (SLE) is a systemic, autoimmune disease that can involve virtually any organ of the body. Lupus nephritis (LN), the clinical manifestation of this disease in the kidney, is one of the most common and severe outcomes of SL
Externí odkaz:
https://doaj.org/article/93100028a19e4a04b7a48ff4ec9b855c