Výsledky vyhledávání - "Andrew J, Godkin"

Akademický článek

CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

Publikováno v: Cell Reports, Vol 32, Iss 2, Pp 107885- (2020)

Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi

Externí odkaz: https://doaj.org/article/ac1881b0cc804226bb104e9cab830657

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Akademický článek

Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells.

Autor: Maria Paula Longhi, Kate Wright, Sarah N Lauder, Mari A Nowell, Gareth W Jones, Andrew J Godkin, Simon A Jones, Awen M Gallimore

Publikováno v: PLoS Pathogens, Vol 4, Iss 2, p e1000006 (2008)

Currently, our understanding of mechanisms underlying cell-mediated immunity and particularly of mechanisms that promote robust T cell memory to respiratory viruses is incomplete. Interleukin (IL)-6 has recently re-emerged as an important regulator o

Externí odkaz: https://doaj.org/article/4f96dab2637f40e18eebf2f95d79e27a

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Akademický článek

CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer.

Autor: Sarah L Clarke, Gareth J Betts, Andrea Plant, Kate L Wright, Tariq M El-Shanawany, Richard Harrop, Jared Torkington, Brian I Rees, Geraint T Williams, Awen M Gallimore, Andrew J Godkin

Publikováno v: PLoS ONE, Vol 1, p e129 (2006)

A wealth of evidence obtained using mouse models indicates that CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) maintain peripheral tolerance to self-antigens and also inhibit anti-tumor immune responses. To date there is limited information about CD

Externí odkaz: https://doaj.org/article/4895a4b8551a4cf1b3dcf51118aa6cb2

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