Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrew J, Geall"'
Autor:
Rebekka Duhen, Michael Beymer, Shawn M. Jensen, Srinivas Abbina, Suraj Abraham, Nikita Jain, Anitha Thomas, Andrew J. Geall, Hong-Ming Hu, Bernard A. Fox, Andrew D. Weinberg
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
To prevent SARS-CoV-2 infections and generate long-lasting immunity, vaccines need to generate strong viral-specific B and T cell responses. Previous results from our lab and others have shown that immunizations in the presence of an OX40 agonist ant
Externí odkaz:
https://doaj.org/article/b5aca7d566d943a9a319e45e455b3eb4
Publikováno v:
Vaccines, Vol 9, Iss 2, p 97 (2021)
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major i
Externí odkaz:
https://doaj.org/article/7e6e71ba07b342fabf2f239a7286cb8c
Publikováno v:
Expert opinion on drug discovery.
Prior to the emergence of SARS-CoV-2, the potential use of mRNA vaccines for a rapid pandemic response had been well described in the scientific literature, however during the SARS-CoV-2 outbreak we witnessed the large-scale deployment of the platfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dca0ae5d36546c9e79d7c98334fb90b
https://pubmed.ncbi.nlm.nih.gov/36384351
https://pubmed.ncbi.nlm.nih.gov/36384351
Autor:
Diletta Magini, Cinzia Giovani, Simona Mangiavacchi, Silvia Maccari, Raffaella Cecchi, Jeffrey B Ulmer, Ennio De Gregorio, Andrew J Geall, Michela Brazzoli, Sylvie Bertholet
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161193 (2016)
Current hemagglutinin (HA)-based seasonal influenza vaccines induce vaccine strain-specific neutralizing antibodies that usually fail to provide protection against mismatched circulating viruses. Inclusion in the vaccine of highly conserved internal
Externí odkaz:
https://doaj.org/article/77a802e3a79e4914ac1f78ea1a9c72e3
Publikováno v:
Cancer gene therapy.
RNA technology has recently come to the forefront of innovative medicines and is being explored for a wide range of therapies, including prophylactic and therapeutic vaccines, biotherapeutic protein expression and gene therapy. In addition to convent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc65214f1c0a94546e919bb74b4e3cd
https://pubmed.ncbi.nlm.nih.gov/35194198
https://pubmed.ncbi.nlm.nih.gov/35194198
Autor:
Luis A, Brito, Sushma, Kommareddy, Domenico, Maione, Yasushi, Uematsu, Cinzia, Giovani, Francesco, Berlanda Scorza, Gillis R, Otten, Dong, Yu, Christian W, Mandl, Peter W, Mason, Philip R, Dormitzer, Jeffrey B, Ulmer, Andrew J, Geall
Publikováno v:
Advances in genetics. 89
This chapter provides a brief introduction to nucleic acid-based vaccines and recent research in developing self-amplifying mRNA vaccines. These vaccines promise the flexibility of plasmid DNA vaccines with enhanced immunogenicity and safety. The key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9058d0ba4ccfd1e4202851d0c755686b
https://pubmed.ncbi.nlm.nih.gov/25620012
https://pubmed.ncbi.nlm.nih.gov/25620012
Autor:
Victor R. Gordeuk, Andrew J. Geall, Biaffra Elliott, Mark Loyevsky, Henrietta Amonoo, Olakunle O. Kassim
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:264-268
The development of resistance by Plasmodium falciparum to conventional drugs poses a threat to malaria control. There is therefore a need to find new, effective, and affordable remedies for malaria, including those derived from plants. This study dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ba2bc1f44210c2286b903a6be0182b
https://doi.org/10.1128/aac.49.1.264-268.2005
https://doi.org/10.1128/aac.49.1.264-268.2005
Autor:
Richard J. Bucala, Yousef Al-Abed, John A. Baugh, Mark Loyevsky, Victor R. Gordeuk, Andrew J. Geall
Publikováno v:
Bioconjugate Chemistry. 15:1161-1165
During the asexual cycle of Plasmodium falciparum within the host erythrocyte, the parasite induces a stage-dependent elevation in the levels of polyamines by increased metabolism and uptake of extracellular pools. Polyamine amides of N-methylanthran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff628020393fd8fbcaa7ba62c79885d0
https://doi.org/10.1021/bc0499578
https://doi.org/10.1021/bc0499578
Publikováno v:
Biochemical Society Transactions. 31:397-406
As a part of our continuing studies on ‘Polyamines and their role in human disease’ we are investigating how polyamines, and especially how novel polyamine conjugates, interact with DNA. We are studying how these conjugates interact with circular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c45a76a566d784edd2d762cb422a299
https://doi.org/10.1042/bst0310397
https://doi.org/10.1042/bst0310397
Publikováno v:
Bioconjugate Chemistry. 13:481-490
Polyamine amides have been prepared from lithocholic and cholic acids (5β-colanes) by acylation of tri-Boc-protected tetraamines spermine and thermine. These designed ligands for DNA are polyammonium ions at physiological pH. In NMR spectra, they di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a6cddd162daaa2712e27a3cbb067795
https://doi.org/10.1021/bc000093+
https://doi.org/10.1021/bc000093+