Výsledky vyhledávání - "Andrew J, Gasparrini"

Maternal activation of the EGFR prevents translocation of gut-residing pathogenic Escherichia coli in a model of late-onset neonatal sepsis

Autor: Rodney D. Newberry, Kathryn A. Knoop, Nurmohammad Shaikh, Misty Good, Alexandria N. Floyd, Phillip I. Tarr, Brigida Rusconi, Barbara B. Warner, Paige E. Coughlin, I. Malick Ndao, Marilyn B. Escobedo, Carla Hall-Moore, Andrew J. Gasparrini

Publikováno v: Proceedings of the National Academy of Sciences. 117:7941-7949

Late-onset sepsis (LOS) is a highly consequential complication of preterm birth and is defined by a positive blood culture obtained after 72 h of age. The causative bacteria can be found in patients’ intestinal tracts days before dissemination, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::004615795e1c857a2991f13ed2875244
https://doi.org/10.1073/pnas.1912022117

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Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

Autor: Andrew J. Gasparrini, Carey-Ann D. Burnham, Bin Wang, Sidra Irum, Meghan A. Wallace, Hirdesh Kumar, Gautam Dantas, Chanez T. Symister, Niraj H. Tolia, Saadia Andleeb, Timothy A. Wencewicz, Jana L. Markley, Luting Fang

Publikováno v: Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)

Tetracycline resistance by antibiotic inactivation was first identified in commensal organisms but has since been reported in environmental and pathogenic microbes. Here, we identify and characterize an expanded pool of tet(X)-like genes in environme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d870eb369593758cfdd51ea0e7d227a
https://doi.org/10.1038/s42003-020-0966-5

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Maternal activation of the EGFR prevents translocation of gut-residing pathogenic

Autor: Kathryn A, Knoop, Paige E, Coughlin, Alexandria N, Floyd, I Malick, Ndao, Carla, Hall-Moore, Nurmohammad, Shaikh, Andrew J, Gasparrini, Brigida, Rusconi, Marilyn, Escobedo, Misty, Good, Barbara B, Warner, Phillip I, Tarr, Rodney D, Newberry

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance The gut-originating pathogen Escherichia coli has been associated with a portion of cases of late-onset sepsis (LOS), a leading cause of neonatal mortality. While it remains unclear how E. coli may gain access to the systemic circulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e917405f1749753331abeae9a65e2ff1
https://pubmed.ncbi.nlm.nih.gov/32179676

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Multiscale Evolutionary Dynamics of Host-Associated Microbiomes

Autor: Gautam Dantas, Andrew J. Gasparrini, Nathan Crook, Aura Ferreiro

Publikováno v: Cell. 172:1216-1227

The composite members of the microbiota face a range of selective pressures, and must adapt to persist in the host. We highlight recent work characterizing the evolution and transfer of genetic information across nested scales of host-associated micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83de3adcf24aa1e4fa0386ba6a0500c4
https://doi.org/10.1016/j.cell.2018.02.015

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Plasticity, dynamics, and inhibition of emerging tetracycline-resistance enzymes

Autor: Chanez T. Symister, Andrew J. Gasparrini, Jennifer L Elliott, Joseph P. Vogel, Margaret R Reck, Jooyoung Park, Niraj H. Tolia, Gautam Dantas, Timothy A. Wencewicz

Publikováno v: Nature chemical biology

Although tetracyclines are an important class of antibiotics for use in agriculture and the clinic, their efficacy is threatened by increasing resistance. Resistance to tetracyclines can occur through efflux, ribosomal protection, or enzymatic inacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3778b77170444917f0d25af9931baf
http://europepmc.org/articles/PMC5478473

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Next-generation approaches to understand and combat the antibiotic resistome

Autor: Terence S. Crofts, Andrew J. Gasparrini, Gautam Dantas

Publikováno v: Nature Reviews Microbiology. 15:422-434

Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of antibiotic resistance genes between habitats, the rapid global spr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c732e9fab41ef002e5499680463370
https://doi.org/10.1038/nrmicro.2017.28

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Adaptive strategies of the candidate probiotic E. coli Nissle in the mammalian gut

Autor: Andrew J. Gasparrini, Xiaoqing Sun, Stephen Dobrowolski, Aura Ferreiro, Nathan Crook, Zevin Condiotte, Mitchell W. Pesesky, Molly K. Gibson, Bin Wang, Daniel A. Peterson, Gautam Dantas

Summary Probiotics are living microorganisms that are increasingly used as gastrointestinal therapeutics by virtue of their innate or engineered genetic function. Unlike abiotic therapeutics, probiotics can replicate in their intended site, subjectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad4cb05df61ba6bab58684298479fee
https://europepmc.org/articles/PMC6487504/

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Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes

Autor: Chanez T. Symister, Hirdesh Kumar, Timothy A. Wencewicz, Luting Fang, Gautam Dantas, Niraj H. Tolia, Jana L. Markley, Andrew J. Gasparrini

The synthesis and biological evaluation of semisynthetic anhydrotetracycline analogues as small molecule inhibitors of tetracycline-inactivating enzymes are reported. Inhibitor potency was found to vary as a function of enzyme (major) and substrate-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a580cd01fecabbd60193796cab8949f5
https://europepmc.org/articles/PMC6490184/

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Antibiotic perturbation of the preterm infant gut microbiome and resistome

Autor: Gautam Dantas, Andrew J. Gasparrini, Molly K. Gibson, Barbara B. Warner, Phillip I. Tarr, Terence S. Crofts

Publikováno v: Gut Microbes. 7:443-449

The gut microbiota plays important roles in nutrient absorption, immune system development, and pathogen colonization resistance. Perturbations early in life may be detrimental to host health in the short and the long-term. Antibiotics are among the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835e11580afbeeff6dbbc12bd3101c9b
https://doi.org/10.1080/19490976.2016.1218584

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Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome

Autor: Bin Wang, Phillip I. Tarr, Ariel Hernandez-Leyva, I. Malick Ndao, Elizabeth A. Kennedy, Barbara B. Warner, Xiaoqing Sun, Andrew J. Gasparrini, Gautam Dantas

Publikováno v: Nature microbiology

Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm infant gut microbiota and resistome pers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32549f651472ae23dc161c749644d480
https://pubmed.ncbi.nlm.nih.gov/31520076

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