Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Andrew J, Finch"'
Autor:
Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K. Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J. Patti, Andrew H. Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R. Kranc, Maria Christophorou, Erika L. Pearce, Ingo Ringshausen, Andrew J. Finch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
MYC activation can sensitise cells to apoptosis upon glutamine withdrawal. Here the authors show that MYC activation enhances global transcription and translation that creates a metabolic demand, while glutamine limitation causes a metabolic demand a
Externí odkaz:
https://doaj.org/article/f58e694b2f6c429fb6bed6c1ae69a6f7
Autor:
Roza H. Ali Masalmeh, Francesca Taglini, Cristina Rubio-Ramon, Kamila I. Musialik, Jonathan Higham, Hazel Davidson-Smith, Ioannis Kafetzopoulos, Kamila P. Pawlicka, Hannah M. Finan, Richard Clark, Jimi Wills, Andrew J. Finch, Lee Murphy, Duncan Sproul
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels
Externí odkaz:
https://doaj.org/article/9803ec9958634a5e94312be4787e0b29
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Enzymatically oxidized lipids are a specific group of biomolecules that function as key signaling mediators and hormones, regulating various cellular and physiological processes from metabolism and cell death to inflammation and the immune response.
Externí odkaz:
https://doaj.org/article/64444fa9a19640fcb7bbfa355831ff11
Publikováno v:
Campbell Systematic Reviews, Vol 14, Iss 1, Pp 1-86 (2018)
This Campbell systematic review examines the effects of recovery schools on student behavioral and academic outcomes, compared to the effects of non‐recovery schools. The review summarizes evidence from one quasi‐experimental study (with a total
Externí odkaz:
https://doaj.org/article/ccf398c7b7a14594ac7cff50c5ee6425
Publikováno v:
Campbell Systematic Reviews, Vol 13, Iss 1, Pp 1-39 (2017)
Externí odkaz:
https://doaj.org/article/4c16eec9cb01465db5d376eeb551e3b9
Autor:
Tamara M Sirey, Kenny Roberts, Wilfried Haerty, Oscar Bedoya-Reina, Sebastian Rogatti-Granados, Jennifer Y Tan, Nick Li, Lisa C Heather, Roderick N Carter, Sarah Cooper, Andrew J Finch, Jimi Wills, Nicholas M Morton, Ana Claudia Marques, Chris P Ponting
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/c93c5ec864b44cedab0bcd20167ad15a
Autor:
Tamara M Sirey, Kenny Roberts, Wilfried Haerty, Oscar Bedoya-Reina, Sebastian Rogatti-Granados, Jennifer Y Tan, Nick Li, Lisa C Heather, Roderick N Carter, Sarah Cooper, Andrew J Finch, Jimi Wills, Nicholas M Morton, Ana Claudia Marques, Chris P Ponting
Publikováno v:
eLife, Vol 8 (2019)
To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and mitochondrial genomes. How an effective stoichiometry of this many constituent s
Externí odkaz:
https://doaj.org/article/7203b3e44ab34c76a17f006cfd21d380
Autor:
Mark T Handley, Kaalak Reddy, Jimi Wills, Elisabeth Rosser, Archith Kamath, Mihail Halachev, Gavin Falkous, Denise Williams, Phillip Cox, Alison Meynert, Eleanor S Raymond, Harris Morrison, Stephen Brown, Emma Allan, Irene Aligianis, Andrew P Jackson, Bernard H Ramsahoye, Alex von Kriegsheim, Robert W Taylor, Andrew J Finch, David R FitzPatrick
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1007605 (2019)
Typical Martsolf syndrome is characterized by congenital cataracts, postnatal microcephaly, developmental delay, hypotonia, short stature and biallelic hypomorphic mutations in either RAB3GAP1 or RAB3GAP2. Genetic analysis of 85 unrelated "mutation n
Externí odkaz:
https://doaj.org/article/192d26f5eb27480d89b58d0f330125b8
Autor:
Syed A. Mian, Céline Philippe, Eleni Maniati, Pantelitsa Protopapa, Tiffany Bergot, Marion Piganeau, Travis Nemkov, Doriana Di Bella, Valle Morales, Andrew J. Finch, Angelo D’Alessandro, Katiuscia Bianchi, Jun Wang, Paolo Gallipoli, Shahram Kordasti, Anne Sophie Kubasch, Michael Cross, Uwe Platzbecker, Daniel H. Wiseman, Dominique Bonnet, Delphine G. Bernard, John G. Gribben, Kevin Rouault-Pierre
Publikováno v:
Science Translational Medicine. 15
Patients with myelodysplastic syndrome and ring sideroblasts (MDS-RS) present with symptomatic anemia due to ineffective erythropoiesis that impedes their quality of life and increases morbidity. More than 80% of patients with MDS-RS harbor splicing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb0c40dcf7205c893a63910acdef89c8
https://doi.org/10.1126/scitranslmed.abn5135
https://doi.org/10.1126/scitranslmed.abn5135
Autor:
Esther Baena, Andrew J. Finch
Publikováno v:
Cancer Discov
Mitochondria provide the front-line of defense against the tumor-promoting effects of oxidative stress. Here we show that the prostate-specific homeoprotein, NKX3.1, suppresses prostate cancer initiation by protecting mitochondria from oxidative stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fc8bf1e4e2488604c619cd4693cc5a
https://doi.org/10.1158/2159-8290.cd-21-0861
https://doi.org/10.1158/2159-8290.cd-21-0861